{
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                [
                    "Rong Qin, Xiangyang Wang, Tingting Fan, Ting Wu, Chao Lu, Xun Shao, Liang Yin (2024). Bilateral inflammatory recurrence of HER-2 positive breast cancer: a unique case report and literature review. Frontiers in oncology, 1276637. https://doi.org/10.3389/fonc.2024.1276637 PMID: 38283858",
                    "38283858"
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                    "Tomomi Nishimura, Ravi Velaga, Norikazu Masuda, Kosuke Kawaguchi, Shuji Kawaguchi, Masahiro Takada, Yurina Maeshima, Sunao Tanaka, Yuichiro Kikawa, Takayuki Kadoya, Hiroko Bando, Rikiya Nakamura, Yutaka Yamamoto, Takayuki Ueno, Hiroyuki Yasojima, Hiroshi Ishiguro, Satoshi Morita, Shinji Ohno, Hironori Haga, Fumihiko Matsuda, Seishi Ogawa, Masakazu Toi (2024). Genomic and transcriptomic profiling of pre- and postneoadjuvant chemotherapy triple negative breast cancer tumors. Cancer science, 3928-3942. https://doi.org/10.1111/cas.16339 PMID: 39375938",
                    "39375938"
                ],
                [
                    "Hang Lu, Xin Yu, Zhiliang Xu, Jingwen Deng, Master Jingwen Zhang, Yimin Zhang, Shengrong Sun (2024). Prognostic Value of IGFBP6 in Breast Cancer: Focus on Glucometabolism. Technology in cancer research & treatment, 15330338241271998. https://doi.org/10.1177/15330338241271998 PMID: 39275851",
                    "39275851"
                ],
                [
                    "Isis de Araújo Ferreira Muniz, Megan Araujo, Jenna Bouassaly, Fatemeh Farshadi, Mai Atique, Khashayar Esfahani, Paulo Rogerio Ferreti Bonan, Michael Hier, Marco Mascarella, Alex Mlynarek, Moulay Alaoui-Jamali, Sabrina Daniela da Silva (2024). Therapeutic Advances and Challenges for the Management of HPV-Associated Oropharyngeal Cancer. International journal of molecular sciences. https://doi.org/10.3390/ijms25074009 PMID: 38612819",
                    "38612819"
                ],
                [
                    "Robert Roskoski (2024). Targeted and cytotoxic inhibitors used in the treatment of breast cancer. Pharmacological research, 107534. https://doi.org/10.1016/j.phrs.2024.107534 PMID: 39631485",
                    "39631485"
                ],
                [
                    "A Grinshpun, S Ren, N Graham, M K DeMeo, E Wrabel, J Carter, N Tayob, A Pereslete, E Hamilton, D Juric, E L Mayer, S M Tolaney, I E Krop, O Metzger (2024). Phase Ib dose-escalation trial of taselisib (GDC-0032) in combination with HER2-directed therapies in patients with advanced HER2+ breast cancer. ESMO open, 103465. https://doi.org/10.1016/j.esmoop.2024.103465 PMID: 38833970",
                    "38833970"
                ],
                [
                    "Aihua Guo, Peilin Zhong, Linghua Wang, Xiurong Lin, Mei Feng (2024). Prognosis and immunotherapeutic implications of molecular classification of cervical cancer based on immunophenoscore-related genes. Journal of biomolecular structure & dynamics, 1-16. https://doi.org/10.1080/07391102.2024.2404545 PMID: 39308337",
                    "39308337"
                ],
                [
                    "S Pignata, D Califano, D Lorusso, L Arenare, M Bartoletti, U De Giorgi, C Andreetta, C Pisano, G Scambia, D Lombardi, A Farolfi, S Cinieri, A Passarelli, V Salutari, C De Angelis, C Mignogna, D Priolo, E D Capoluongo, S Tamberi, G L Scaglione, V Arcangeli, R De Cecio, G Scognamiglio, F Greco, A Spina, M Turinetto, D Russo, V Carbone, C Casartelli, C Schettino, F Perrone (2024). MITO END-3: efficacy of avelumab immunotherapy according to molecular profiling in first-line endometrial cancer therapy. Annals of oncology : official journal of the European Society for Medical Oncology, 667-676. https://doi.org/10.1016/j.annonc.2024.04.007 PMID: 38704093",
                    "38704093"
                ],
                [
                    "Rebecca A Dent, Sung-Bae Kim, Mafalda Oliveira, Carlos Barrios, Joyce O'Shaughnessy, Steven J Isakoff, Shigehira Saji, Ruffo Freitas-Junior, Manuel Philco, Igor Bondarenko, Qinshu Lian, Denise Bradley, Heather Hinton, Matthew J Wongchenko, Sarah-Jayne Reilly, Nicholas Turner (2024). Ipatasertib plus Paclitaxel for Patients with PIK3CA/AKT1/PTEN-Altered Locally Advanced Unresectable or Metastatic Triple-Negative Breast Cancer in the IPATunity130 Phase III Trial. Clinical cancer research : an official journal of the American Association for Cancer Research, 4329-4338. https://doi.org/10.1158/1078-0432.CCR-24-0465 PMID: 39058425",
                    "39058425"
                ],
                [
                    "Mohammad Alwahsh, Amani Al-Doridee, Suhair Jasim, Oriana Awwad, Roland Hergenröder, Lama Hamadneh (2024). Cytotoxic and molecular differences of anticancer agents on 2D and 3D cell culture. Molecular biology reports, 721. https://doi.org/10.1007/s11033-024-09669-1 PMID: 38829450",
                    "38829450"
                ]
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                    "Adrish Sen, Salmaan Khan, Stefano Rossetti, Aaron Broege, Ian MacNeil, Ann DeLaForest, Jhomary Molden, Laura Davis, Charles Iversrud, Megan Seibel, Ross Kopher, Stephen Schulz, Lance Laing (2025). Assessments of prostate cancer cell functions highlight differences between a pan-PI3K/mTOR inhibitor, gedatolisib, and single-node inhibitors of the PI3K/AKT/mTOR pathway. Molecular oncology, 225-247. https://doi.org/10.1002/1878-0261.13703 PMID: 39092562",
                    "39092562"
                ],
                [
                    "Matt Shirley (2024). Capivasertib: First Approval. Drugs, 337-346. https://doi.org/10.1007/s40265-024-01998-6 PMID: 38388873",
                    "38388873"
                ],
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                    "38954770"
                ],
                [
                    "Mafalda Oliveira, Hope S Rugo, Sacha J Howell, Florence Dalenc, Javier Cortes, Henry L Gomez, Xichun Hu, Masakazu Toi, Komal Jhaveri, Petr Krivorotko, Sibylle Loibl, Serafin Morales Murillo, Meena Okera, Zbigniew Nowecki, Yeon Hee Park, Joo Hyuk Sohn, Eriko Tokunaga, Samih Yousef, Lyudmila Zhukova, Marta Fulford, Haylee Andrews, Ian Wadsworth, Celina D'Cruz, Nicholas C Turner,   (2024). Capivasertib and fulvestrant for patients with hormone receptor-positive, HER2-negative advanced breast cancer (CAPItello-291): patient-reported outcomes from a phase 3, randomised, double-blind, placebo-controlled trial. The Lancet. Oncology, 1231-1244. https://doi.org/10.1016/S1470-2045(24)00373-5 PMID: 39214106",
                    "39214106"
                ],
                [
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                ],
                [
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                    "39674130"
                ],
                [
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                    "39317592"
                ],
                [
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                    "38815877"
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                [
                    "Ursula Grazini, Aleksandra Markovets, Lucy Ireland, Daniel O'Neill, Benjamin Phillips, Man Xu, Matthias Pfeifer, Tereza Vaclova, Matthew J Martin, Ludovic Bigot, Luc Friboulet, Ryan Hartmaier, Maria E Cuomo, Simon T Barry, Paul D Smith, Nicolas Floc'h (2024). Overcoming Osimertinib Resistance with AKT Inhibition in EGFRm-Driven Non-Small Cell Lung Cancer with PIK3CA/PTEN Alterations. Clinical cancer research : an official journal of the American Association for Cancer Research, 4143-4154. https://doi.org/10.1158/1078-0432.CCR-23-2540 PMID: 38630555",
                    "38630555"
                ],
                [
                    "Midori Morita, Ryo Tsunashima, Tetsuhiro Yoshinami, Masaki Ishida, Masahiro Iwasaku, Sae Kitano, Chikage Kato, Koichi Sakaguchi, Koichi Takayama, Yasuto Naoi (2024). A 5-year review of genomic medicine in breast cancer: insights from C-CAT data on 3776 Japanese patients. Breast cancer (Tokyo, Japan). https://doi.org/10.1007/s12282-024-01656-5 PMID: 39630210",
                    "39630210"
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                [
                    "Yaqi Zhang, Yinu Wang, Andres Valdivia, Hao Huang, Daniela Matei (2023). DOT1 L Regulates Ovarian Cancer Stem Cells by Activating β-catenin Signaling. Molecular cancer research : MCR, 140-154. https://doi.org/10.1158/1541-7786.MCR-22-0418 PMID: 36318113",
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                ],
                [
                    "Yang Si, Corentin Bon, Magdalena Barbachowska, Veronique Cadet-Daniel, Corinne Jallet, Laura Soresinetti, Mikaël Boullé, Magalie Duchateau, Mariette Matondo, Fabrice Agou, Ludovic Halby, Paola B Arimondo (2022). A novel screening strategy to identify histone methyltransferase inhibitors reveals a crosstalk between DOT1L and CARM1. RSC chemical biology, 456-467. https://doi.org/10.1039/d1cb00095k PMID: 35441144",
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                ],
                [
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                ],
                [
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                ],
                [
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                ],
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                ],
                [
                    "Katelyn E Heimbruch, Joseph B Fisher, Cary T Stelloh, Emily Phillips, Michael H Reimer, Adam J Wargolet, Alison E Meyer, Kirthi Pulakanti, Aaron D Viny, Jessica J Loppnow, Ross L Levine, John Anto Pulikkan, Nan Zhu, Sridhar Rao (2021). DOT1L inhibitors block abnormal self-renewal induced by cohesin loss. Scientific reports, 7288. https://doi.org/10.1038/s41598-021-86646-9 PMID: 33790356",
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                ],
                [
                    "Wanlin Yang, Hongshuang Yu, Jiefang Huang, Xiang Miao, Qiwei Wang, Yanan Wang, Yiji Cheng, Shan He, Fang Zhao, Lijun Meng, Bei Wang, Fengtao Qian, Xiaohui Ren, Min Jin, Yuting Gu, Yanyun Zhang, Wei Cai (2021). Inhibition of Dot1L Alleviates Fulminant Hepatitis Through Myeloid-Derived Suppressor Cells. Cellular and molecular gastroenterology and hepatology, 81-98. https://doi.org/10.1016/j.jcmgh.2021.01.013 PMID: 33497867",
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                ],
                [
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                    "Manuel Valladares-Ayerbes, Maria José Safont, Encarnación González Flores, Pilar García-Alfonso, Enrique Aranda, Ana-Maria López Muñoz, Esther Falcó Ferrer, Luís Cirera Nogueras, Nuria Rodríguez-Salas, Jorge Aparicio, Marta Llanos Muñoz, Paola Patricia Pimentel Cáceres, Oscar Alfredo Castillo Trujillo, Rosario Vidal Tocino, Mercedes Salgado Fernández, Antonieta Salud-Salvia, Bartomeu Massuti Sureda, Rocio Garcia-Carbonero, Maria Ángeles Vicente Conesa, Ariadna Lloansí Vila,   (2024). Sequential RAS mutations evaluation in cell-free DNA of patients with tissue RAS wild-type metastatic colorectal cancer: the PERSEIDA (Cohort 2) study. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2640-2651. https://doi.org/10.1007/s12094-024-03487-4 PMID: 38642257",
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                ],
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                ],
                [
                    "Kohei Shitara, Kei Muro, Jun Watanabe, Kentaro Yamazaki, Hisatsugu Ohori, Manabu Shiozawa, Atsuo Takashima, Mitsuru Yokota, Akitaka Makiyama, Naoya Akazawa, Hitoshi Ojima, Yasuhiro Yuasa, Keisuke Miwa, Hirofumi Yasui, Eiji Oki, Takeo Sato, Takeshi Naitoh, Yoshito Komatsu, Takeshi Kato, Ikuo Mori, Kazunori Yamanaka, Masamitsu Hihara, Junpei Soeda, Toshihiro Misumi, Kouji Yamamoto, Riu Yamashita, Kiwamu Akagi, Atsushi Ochiai, Hiroyuki Uetake, Katsuya Tsuchihara, Takayuki Yoshino (2024). Baseline ctDNA gene alterations as a biomarker of survival after panitumumab and chemotherapy in metastatic colorectal cancer. Nature medicine, 730-739. https://doi.org/10.1038/s41591-023-02791-w PMID: 38347302",
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                ],
                [
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                ],
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                ],
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                ],
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                ],
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                ]
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        ],
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            ],
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                ],
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                ],
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        ],
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                "PIK3CA"
            ],
            7.036307399999999
        ],
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            [
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                "DOT1L"
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            7.036307399999999
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        [
            [
                "SOS1",
                "PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER"
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            ],
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}