{
    "nodes": [
        [
            "TRPM4",
            "GENE"
        ],
        [
            "PKP2",
            "GENE"
        ],
        [
            "Brugada Syndrome",
            "DISEASE"
        ],
        [
            "SCN5A",
            "GENE"
        ],
        [
            "SCN1B",
            "GENE"
        ],
        [
            "CACNB2",
            "GENE"
        ],
        [
            "SCN10A",
            "GENE"
        ],
        [
            "KCND3",
            "GENE"
        ],
        [
            "SCN3B",
            "GENE"
        ],
        [
            "GPD1L",
            "GENE"
        ],
        [
            "CACNA1C",
            "GENE"
        ]
    ],
    "edges": [
        [
            [
                "Brugada Syndrome",
                "KCND3"
            ],
            11.965413,
            [
                [
                    "Md Ripon Ahammed, Fariha Noor Ananya (2023). Association of Cardiac Electrical Disorders With KCND3 Gene Mutation. Cureus, e34597. https://doi.org/10.7759/cureus.34597 PMID: 36883079",
                    "36883079"
                ],
                [
                    "Dan Ye, Wei Zhou, Samantha K Hamrick, David J Tester, C S John Kim, Hector Barajas-Martinez, Dan Hu, John R Giudicessi, Charles Antzelevitch, Michael J Ackerman (2022). Acacetin, a Potent Transient Outward Current Blocker, May Be a Novel Therapeutic for KCND3-Encoded Kv4.3 Gain-of-Function-Associated J-Wave Syndromes. Circulation. Genomic and precision medicine, e003238. https://doi.org/10.1161/CIRCGEN.120.003238 PMID: 35861988",
                    "35861988"
                ],
                [
                    "Gang Yu, Susmita Chakrabarti, Miroslava Tischenko, Ai-Lan Chen, Zhijie Wang, Hyosuk Cho, Brent A French, Sathyamangla V Naga Prasad, Qiuyun Chen, Qing K Wang (2022). Gene therapy targeting protein trafficking regulator MOG1 in mouse models of Brugada syndrome, arrhythmias, and mild cardiomyopathy. Science translational medicine, eabf3136. https://doi.org/10.1126/scitranslmed.abf3136 PMID: 35675436",
                    "35675436"
                ],
                [
                    "Tadashi Nakajima, Shuntaro Tamura, Masahiko Kurabayashi, Yoshiaki Kaneko (2021). Towards Mutation-Specific Precision Medicine in Atypical Clinical Phenotypes of Inherited Arrhythmia Syndromes. International journal of molecular sciences. https://doi.org/10.3390/ijms22083930 PMID: 33920294",
                    "33920294"
                ],
                [
                    "Zhong-He Zhang, Hector Barajas-Martínez, Hao Xia, Bian Li, John A Capra, Jerome Clatot, Gan-Xiao Chen, Xiu Chen, Bo Yang, Hong Jiang, Gary Tse, Yoshiyasu Aizawa, Michael H Gollob, Melvin Scheinman, Charles Antzelevitch, Dan Hu (2021). Distinct Features of Probands With Early Repolarization and Brugada Syndromes Carrying SCN5A Pathogenic Variants. Journal of the American College of Cardiology, 1603-1617. https://doi.org/10.1016/j.jacc.2021.08.024 PMID: 34649698",
                    "34649698"
                ],
                [
                    "Xianqing Li, Zongzhe Li, Dao Wen Wen Wang, Dao Wu Wang, Yan Wang (2020). A Novel Gain-of-Function KCND3 Variant Associated with Brugada Syndrome. Cardiology, 623-632. https://doi.org/10.1159/000508033 PMID: 32818936",
                    "32818936"
                ],
                [
                    "Jérôme Clatot, Nathalie Neyroud, Robert Cox, Charlotte Souil, Jing Huang, Pascale Guicheney, Charles Antzelevitch (2020). Inter-Regulation of Kv4.3 and Voltage-Gated Sodium Channels Underlies Predisposition to Cardiac and Neuronal Channelopathies. International journal of molecular sciences. https://doi.org/10.3390/ijms21145057 PMID: 32709127",
                    "32709127"
                ],
                [
                    "Isabel D Derera, Katalin Cs Smith, Bret N Smith (2019). Altered A-type potassium channel function in the nucleus tractus solitarii in acquired temporal lobe epilepsy. Journal of neurophysiology, 177-187. https://doi.org/10.1152/jn.00556.2018 PMID: 30517061",
                    "30517061"
                ],
                [
                    "Jiaping Wang, Yongxin Wen, Qingping Zhang, Shujie Yu, Yan Chen, Xiru Wu, YueHua Zhang, Xinhua Bao (2019). Gene mutational analysis in a cohort of Chinese children with unexplained epilepsy: Identification of a new KCND3 phenotype and novel genes causing Dravet syndrome. Seizure, 26-30. https://doi.org/10.1016/j.seizure.2019.01.025 PMID: 30776697",
                    "30776697"
                ],
                [
                    "Vincent Portero, Ronald Wilders, Simona Casini, Flavien Charpentier, Arie O Verkerk, Carol Ann Remme (2018). KV4.3 Expression Modulates NaV1.5 Sodium Current. Frontiers in physiology, 178. https://doi.org/10.3389/fphys.2018.00178 PMID: 29593552",
                    "29593552"
                ]
            ]
        ],
        [
            [
                "Brugada Syndrome",
                "TRPM4"
            ],
            11.950508000000001,
            [
                [
                    "Svetlana I Tarnovskaya, Anna A Kostareva, Boris S Zhorov (2023). In silico analysis of TRPM4 variants of unknown clinical significance. PloS one, e0295974. https://doi.org/10.1371/journal.pone.0295974 PMID: 38100498",
                    "38100498"
                ],
                [
                    "Angelo Auricchio, Andrea Demarchi, Tardu Özkartal, Daniela Campanale, Maria Luce Caputo, Marcello di Valentino, Andrea Menafoglio, Francois Regoli, Marco Facchini, Alessandro Del Bufalo, Pietro Foglia, Nicola Ferrari, Fulvio Bomio, Argelia Medeiros-Domingo, Tiziano Moccetti, Giovanni B Pedrazzini, Catherine Klersy, Giulio Conte (2023). Role of genetic testing in young patients with idiopathic atrioventricular conduction disease. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 643-650. https://doi.org/10.1093/europace/euac196 PMID: 36352534",
                    "36352534"
                ],
                [
                    "Hongkun Wang, Lizhen Xu, Shuai Han, Xiaochen Wang, Hao Wang, Jingjun Zhou, Jiaxi Shen, Zongkuai Yang, Luyang Yu, Zhouqing Huang, Tingyu Gong, Ming Qi, Fan Yang, Ping Liang (2022). Hyperactivation of platelet-derived growth factor signalling contributes to arrhythmogenesis in Brugada syndrome. Clinical and translational medicine, e715. https://doi.org/10.1002/ctm2.715 PMID: 35184407",
                    "35184407"
                ],
                [
                    "Lijo Cherian Ozhathil, Jean-Sébastien Rougier, Prakash Arullampalam, Maria C Essers, Daniela Ross-Kaschitza, Hugues Abriel (2021). Deletion of Trpm4 Alters the Function of the Nav1.5 Channel in Murine Cardiac Myocytes. International journal of molecular sciences. https://doi.org/10.3390/ijms22073401 PMID: 33810249",
                    "33810249"
                ],
                [
                    "Richa Tambi, Reem Abdel Hameid, Asma Bankapur, Nasna Nassir, Ghausia Begum, Alawi Alsheikh-Ali, Mohammed Uddin, Bakhrom K Berdiev (2021). Single-cell transcriptomics trajectory and molecular convergence of clinically relevant mutations in Brugada syndrome. American journal of physiology. Heart and circulatory physiology, H1935-H1948. https://doi.org/10.1152/ajpheart.00061.2021 PMID: 33797273",
                    "33797273"
                ],
                [
                    "Mohamed-Yassine Amarouch, Jaouad El Hilaly (2020). Inherited Cardiac Arrhythmia Syndromes: Focus on Molecular Mechanisms Underlying TRPM4 Channelopathies. Cardiovascular therapeutics, 6615038. https://doi.org/10.1155/2020/6615038 PMID: 33381229",
                    "33381229"
                ],
                [
                    "Alexandre Janin, Francis Bessière, Tudor Georgescu, Valérie Chanavat, Philippe Chevalier, Gilles Millat (2019). TRPM4 mutations to cause autosomal recessive and not autosomal dominant Brugada type 1 syndrome. European journal of medical genetics, 103527. https://doi.org/10.1016/j.ejmg.2018.08.008 PMID: 30142439",
                    "30142439"
                ],
                [
                    "Beatrice Bianchi, Lijo Cherian Ozhathil, Argelia Medeiros-Domingo, Michael H Gollob, Hugues Abriel (2018). Four TRPM4 Cation Channel Mutations Found in Cardiac Conduction Diseases Lead to Altered Protein Stability. Frontiers in physiology, 177. https://doi.org/10.3389/fphys.2018.00177 PMID: 29568272",
                    "29568272"
                ],
                [
                    "Francesca Gualandi, Fatima Zaraket, Michele Malagù, Giulia Parmeggiani, Cecilia Trabanelli, Sergio Fini, Xiao Dang, Xiaoming Wei, Mingyan Fang, Matteo Bertini, Roberto Ferrari, Alessandra Ferlini (2017). Mutation Load of Multiple Ion Channel Gene Mutations in Brugada Syndrome. Cardiology, 256-260. https://doi.org/10.1159/000471792 PMID: 28494446",
                    "28494446"
                ],
                [
                    "Ninda Syam, Stéphanie Chatel, Lijo Cherian Ozhathil, Valentin Sottas, Jean-Sébastien Rougier, Alban Baruteau, Estelle Baron, Mohamed-Yassine Amarouch, Xavier Daumy, Vincent Probst, Jean-Jacques Schott, Hugues Abriel (2016). Variants of Transient Receptor Potential Melastatin Member 4 in Childhood Atrioventricular Block. Journal of the American Heart Association. PMID: 27207958",
                    "27207958"
                ]
            ]
        ],
        [
            [
                "Brugada Syndrome",
                "CACNB2"
            ],
            11.947588,
            [
                [
                    "Nirmalatiban Parthiban, Huzairi Sani (2023). Sudden cardiac arrest in a patient with malignant mitral valve prolapse with CACNB2 gene mutation: a simple coincidence or coexistence?-a case report. European heart journal. Case reports, ytad196. https://doi.org/10.1093/ehjcr/ytad196 PMID: 37123658",
                    "37123658"
                ],
                [
                    "Rujia Zhong, Theresa Schimanski, Feng Zhang, Huan Lan, Alyssa Hohn, Qiang Xu, Mengying Huang, Zhenxing Liao, Lin Qiao, Zhen Yang, Yingrui Li, Zhihan Zhao, Xin Li, Lena Rose, Sebastian Albers, Lasse Maywald, Jonas Müller, Hendrik Dinkel, Ardan Saguner, Johannes W G Janssen, Narasimha Swamy, Yannick Xi, Siegfried Lang, Mandy Kleinsorge, Firat Duru, Xiaobo Zhou, Sebastian Diecke, Lukas Cyganek, Ibrahim Akin, Ibrahim El-Battrawy (2022). A Preclinical Study on Brugada Syndrome with a CACNB2 Variant Using Human Cardiomyocytes from Induced Pluripotent Stem Cells. International journal of molecular sciences. https://doi.org/10.3390/ijms23158313 PMID: 35955449",
                    "35955449"
                ],
                [
                    "Vittoria Di Mauro, Paola Ceriotti, Francesco Lodola, Nicolò Salvarani, Jessica Modica, Marie-Louise Bang, Andrea Mazzanti, Carlo Napolitano, Silvia G Priori, Daniele Catalucci (2020). Peptide-Based Targeting of the L-Type Calcium Channel Corrects the Loss-of-Function Phenotype of Two Novel Mutations of the CACNA1 Gene Associated With Brugada Syndrome. Frontiers in physiology, 616819. https://doi.org/10.3389/fphys.2020.616819 PMID: 33488405",
                    "33488405"
                ],
                [
                    "Malorie Blancard, Amal Debbiche, Koichi Kato, Christelle Cardin, Guichard Sabrina, Estelle Gandjbakhch, Vincent Probst, Michel Haissaguerre, Fabrice Extramiana, Mélèze Hocini, Geoffroy Olivier, Antoine Leenhardt, Pascale Guicheney, Jean-Sébastien Rougier (2018). An African loss-of-function CACNA1C variant p.T1787M associated with a risk of ventricular fibrillation. Scientific reports, 14619. https://doi.org/10.1038/s41598-018-32867-4 PMID: 30279520",
                    "30279520"
                ],
                [
                    "Liyong Zhang, David J Tester, Di Lang, Yili Chen, Jinxiang Zheng, Rui Gao, Robert F Corliss, Shuangbo Tang, John W Kyle, Chao Liu, Michael J Ackerman, Jonathan C Makielski, Jianding Cheng (2016). Does Sudden Unexplained Nocturnal Death Syndrome Remain the Autopsy-Negative Disorder: A Gross, Microscopic, and Molecular Autopsy Investigation in Southern China. Mayo Clinic proceedings, 1503-1514. https://doi.org/10.1016/j.mayocp.2016.06.031 PMID: 27707468",
                    "27707468"
                ],
                [
                    "Catarina Allegue, Mònica Coll, Jesus Mates, Oscar Campuzano, Anna Iglesias, Beatriz Sobrino, Maria Brion, Jorge Amigo, Angel Carracedo, Pedro Brugada, Josep Brugada, Ramon Brugada (2015). Genetic Analysis of Arrhythmogenic Diseases in the Era of NGS: The Complexity of Clinical Decision-Making in Brugada Syndrome. PloS one, e0133037. https://doi.org/10.1371/journal.pone.0133037 PMID: 26230511",
                    "26230511"
                ],
                [
                    "Amane Araki, Masahisa Katsuno, Keisuke Suzuki, Haruhiko Banno, Noriaki Suga, Atsushi Hashizume, Tomoo Mano, Yasuhiro Hijikata, Hideaki Nakatsuji, Hirohisa Watanabe, Masahiko Yamamoto, Takeru Makiyama, Seiko Ohno, Megumi Fukuyama, Shin-Ichiro Morimoto, Minoru Horie, Gen Sobue (2014). Brugada syndrome in spinal and bulbar muscular atrophy. Neurology, 1813-21. https://doi.org/10.1212/WNL.0000000000000434 PMID: 24759840",
                    "24759840"
                ],
                [
                    "Megumi Fukuyama, Seiko Ohno, Qi Wang, Hiromi Kimura, Takeru Makiyama, Hideki Itoh, Makoto Ito, Minoru Horie (2013). L-type calcium channel mutations in Japanese patients with inherited arrhythmias. Circulation journal : official journal of the Japanese Circulation Society, 1799-806. https://doi.org/10.1253/circj.cj-12-1457 PMID: 23575362",
                    "23575362"
                ],
                [
                    "B Risgaard, R Jabbari, L Refsgaard, A G Holst, S Haunsø, A Sadjadieh, B G Winkel, M S Olesen, J Tfelt-Hansen (2013). High prevalence of genetic variants previously associated with Brugada syndrome in new exome data. Clinical genetics, 489-95. https://doi.org/10.1111/cge.12126 PMID: 23414114",
                    "23414114"
                ],
                [
                    "Ronald J Kanter, Ryan Pfeiffer, Dan Hu, Héctor Barajas-Martinez, Michael P Carboni, Charles Antzelevitch (2012). Brugada-like syndrome in infancy presenting with rapid ventricular tachycardia and intraventricular conduction delay. Circulation, 14-22. https://doi.org/10.1161/CIRCULATIONAHA.111.054007 PMID: 22090166",
                    "22090166"
                ]
            ]
        ],
        [
            [
                "Brugada Syndrome",
                "SCN10A"
            ],
            11.98171,
            [
                [
                    "Lu-Chen Weng, Shaan Khurshid, Amelia Weber Hall, Victor Nauffal, Valerie N Morrill, Yan V Sun, Joel T Rämö, Dominik Beer, Simon Lee, Girish Nadkarni, Renee Johnson, Laura Andreasen, Anne Clayton, Clive R Pullinger, Zachary T Yoneda, Daniel J Friedman, Matthew C Hyman, Renae L Judy, Allan C Skanes, Kate M Orland, Paloma Jordà, Timothy M Treu, Matthew T Oetjens, Rajesh Subbiah, Jacob P Hartmann, Heidi T May, John P Kane, Tariq Z Issa, Navid A Nafissi, Peter Leong-Sit, Marie-Pierre Dubé, Carolina Roselli, Seung Hoan Choi,  , Jean-Claude Tardif, Habib R Khan, Stacey Knight, Jesper H Svendsen, Bruce Walker, Richard Karlsson Linnér, J Michael Gaziano, Rafik Tadros, Diane Fatkin, Daniel J Rader, Svati H Shah, Dan M Roden, Gregory M Marcus, Ruth J F Loos, Scott M Damrauer, Christopher M Haggerty, Kelly Cho, Aarno Palotie, Morten S Olesen, Lee L Eckhardt, Jason D Roberts, Michael J Cutler, M Benjamin Shoemaker, Peter W F Wilson, Patrick T Ellinor, Steven A Lubitz (2024). Meta-Analysis of Genome-Wide Association Studies Reveals Genetic Mechanisms of Supraventricular Arrhythmias. Circulation. Genomic and precision medicine, e004320. https://doi.org/10.1161/CIRCGEN.123.004320 PMID: 38804128",
                    "38804128"
                ],
                [
                    "Aaron Isaacs, Andrei Barysenka, Rachel M A Ter Bekke, Apollonia T J M Helderman-van den Enden, Arthur van den Wijngaard, Paul G A Volders, Monika Stoll (2023). Standing genetic variation affects phenotypic heterogeneity in an SCN5A-mutation founder population with excess sudden cardiac death. Heart rhythm, 720-727. https://doi.org/10.1016/j.hrthm.2023.02.004 PMID: 36764349",
                    "36764349"
                ],
                [
                    "Nico Hartmann, Maria Knierim, Wiebke Maurer, Nataliya Dybkova, Gerd Hasenfuß, Samuel Sossalla, Katrin Streckfuss-Bömeke (2023). Molecular and Functional Relevance of NaV1.8-Induced Atrial Arrhythmogenic Triggers in a Human SCN10A Knock-Out Stem Cell Model. International journal of molecular sciences. https://doi.org/10.3390/ijms241210189 PMID: 37373335",
                    "37373335"
                ],
                [
                    "Zhenxing Liao, Yingrui Li, Xuehui Fan, Zhen Yang, Ibrahim El-Battrawy, Xiaobo Zhou, Ibrahim Akin (2022). Lipopolysaccharide Modifies Sodium Current Kinetics through ROS and PKC Signalling in Induced Pluripotent Stem-Derived Cardiomyocytes from Brugada Syndrome Patient. Journal of cardiovascular development and disease. https://doi.org/10.3390/jcdd9040119 PMID: 35448095",
                    "35448095"
                ],
                [
                    "Yan Huang, Xiao-Meng Chen, Hector Barajas-Martinez, Hong Jiang, Charles Antzelevitch, Dan Hu (2021). Common variants in SCN10A gene associated with Brugada syndrome. Human molecular genetics, 157-165. https://doi.org/10.1093/hmg/ddab217 PMID: 34312669",
                    "34312669"
                ],
                [
                    "Richa Tambi, Reem Abdel Hameid, Asma Bankapur, Nasna Nassir, Ghausia Begum, Alawi Alsheikh-Ali, Mohammed Uddin, Bakhrom K Berdiev (2021). Single-cell transcriptomics trajectory and molecular convergence of clinically relevant mutations in Brugada syndrome. American journal of physiology. Heart and circulatory physiology, H1935-H1948. https://doi.org/10.1152/ajpheart.00061.2021 PMID: 33797273",
                    "33797273"
                ],
                [
                    "Joyce C K Man, Fernanda M Bosada, Koen T Scholman, Joost A Offerhaus, Roddy Walsh, Karel van Duijvenboden, Vincent W W van Eif, Connie R Bezzina, Arie O Verkerk, Bastiaan J Boukens, Phil Barnett, Vincent M Christoffels (2021). Variant Intronic Enhancer Controls SCN10A-short Expression and Heart Conduction. Circulation, 229-242. https://doi.org/10.1161/CIRCULATIONAHA.121.054083 PMID: 33910361",
                    "33910361"
                ],
                [
                    "Adrian Pérez-Agustín, Mel Lina Pinsach-Abuin, Sara Pagans (2020). Role of Non-Coding Variants in Brugada Syndrome. International journal of molecular sciences. https://doi.org/10.3390/ijms21228556 PMID: 33202810",
                    "33202810"
                ],
                [
                    "Liang Hong, Meihong Zhang, Arvind Sridhar, Dawood Darbar (2020). Pathogenic mutations perturb calmodulin regulation of Nav1.8 channel. Biochemical and biophysical research communications, 168-174. https://doi.org/10.1016/j.bbrc.2020.08.010 PMID: 32948286",
                    "32948286"
                ],
                [
                    "Pattarapong Makarawate, Charlotte Glinge, Apichai Khongphatthanayothin, Roddy Walsh, John Mauleekoonphairoj, Montawatt Amnueypol, Somchai Prechawat, Wanwarang Wongcharoen, Rungroj Krittayaphong, Alisara Anannab, Peter Lichtner, Thomas Meitinger, Fleur V Y Tjong, Krystien V V Lieve, Ahmad S Amin, Dujdao Sahasatas, Tachapong Ngarmukos, Duangdao Wichadakul, Sunchai Payungporn, Boosamas Sutjaporn, Pharawee Wandee, Yong Poovorawan, Jacob Tfelt-Hansen, Michael W T Tanck, Rafik Tadros, Arthur A M Wilde, Connie R Bezzina, Gumpanart Veerakul, Koonlawee Nademanee (2020). Common and rare susceptibility genetic variants predisposing to Brugada syndrome in Thailand. Heart rhythm, 2145-2153. https://doi.org/10.1016/j.hrthm.2020.06.027 PMID: 32619740",
                    "32619740"
                ]
            ]
        ],
        [
            [
                "Brugada Syndrome",
                "CACNA1C"
            ],
            11.981665000000001,
            [
                [
                    "Lorenzo Cipriano, Raffaele Piscopo, Chiara Aiello, Antonio Novelli, Achille Iolascon, Carmelo Piscopo (2024). Expanding the Phenotype of the CACNA1C-Associated Neurological Disorders in Children: Systematic Literature Review and Description of a Novel Mutation. Children (Basel, Switzerland). https://doi.org/10.3390/children11050541 PMID: 38790536",
                    "38790536"
                ],
                [
                    "Asami Kashiwa, Takeru Makiyama, Hirohiko Kohjitani, Thomas L Maurissen, Taisuke Ishikawa, Yuta Yamamoto, Yimin Wuriyanghai, Jingshan Gao, Hai Huang, Tomohiko Imamura, Takanori Aizawa, Misato Nishikawa, Kazuhisa Chonabayashi, Hiroyuki Mishima, Seiko Ohno, Futoshi Toyoda, Seiichi Sato, Koh-Ichiro Yoshiura, Kazuhiro Takahashi, Yoshinori Yoshida, Knut Woltjen, Minoru Horie, Naomasa Makita, Takeshi Kimura (2023). Disrupted CaV1.2 selectivity causes overlapping long QT and Brugada syndrome phenotypes in the CACNA1C-E1115K iPS cell model. Heart rhythm, 89-99. https://doi.org/10.1016/j.hrthm.2022.08.021 PMID: 36007726",
                    "36007726"
                ],
                [
                    "Bin Zeng, Xiang Zhang, Rainer Schimpf, Andrew Powers, Michael Glikson, Charles Antzelevitch, Dan Hu, Hector Barajas-Martinez (2023). Functional identification of hot-spot mutations in cardiac calcium channel genes associated with the J wave syndromes. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 20220286. https://doi.org/10.1098/rstb.2022.0286 PMID: 37122210",
                    "37122210"
                ],
                [
                    "Gang Yu, Susmita Chakrabarti, Miroslava Tischenko, Ai-Lan Chen, Zhijie Wang, Hyosuk Cho, Brent A French, Sathyamangla V Naga Prasad, Qiuyun Chen, Qing K Wang (2022). Gene therapy targeting protein trafficking regulator MOG1 in mouse models of Brugada syndrome, arrhythmias, and mild cardiomyopathy. Science translational medicine, eabf3136. https://doi.org/10.1126/scitranslmed.abf3136 PMID: 35675436",
                    "35675436"
                ],
                [
                    "Valeria Novelli, Mirella Memmi, Alberto Malovini, Andrea Mazzanti, Nian Liu, Ruan Yanfei, Rossana Bongianino, Marco Denegri, Nicola Monteforte, Raffaella Bloise, Massimo Morini, Carlo Napolitano (2022). Role of CACNA1C in Brugada syndrome: Prevalence and phenotype of probands referred for genetic testing. Heart rhythm, 798-806. https://doi.org/10.1016/j.hrthm.2021.12.032 PMID: 34999275",
                    "34999275"
                ],
                [
                    "Michelle M Monasky, Carola Rutigliani, Emanuele Micaglio, Carlo Pappone (2021). Commentary: Peptide-Based Targeting of the L-Type Calcium Channel Corrects the Loss-of-Function Phenotype of Two Novel Mutations of the CACNA1 Gene Associated With Brugada Syndrome. Frontiers in physiology, 682567. https://doi.org/10.3389/fphys.2021.682567 PMID: 34177625",
                    "34177625"
                ],
                [
                    "Vittoria Di Mauro, Paola Ceriotti, Francesco Lodola, Nicolò Salvarani, Jessica Modica, Marie-Louise Bang, Andrea Mazzanti, Carlo Napolitano, Silvia G Priori, Daniele Catalucci (2020). Peptide-Based Targeting of the L-Type Calcium Channel Corrects the Loss-of-Function Phenotype of Two Novel Mutations of the CACNA1 Gene Associated With Brugada Syndrome. Frontiers in physiology, 616819. https://doi.org/10.3389/fphys.2020.616819 PMID: 33488405",
                    "33488405"
                ],
                [
                    "Catia Mio, Nadia Passon, Federica Baldan, Elisa Bregant, Elisabetta Monaco, Loretta Mancini, Eliana Demori, Giuseppe Damante (2020). CACNA1C haploinsufficiency accounts for the common features of interstitial 12p13.33 deletion carriers. European journal of medical genetics, 103843. https://doi.org/10.1016/j.ejmg.2020.103843 PMID: 31953239",
                    "31953239"
                ],
                [
                    "P E Maltese, E Aldanova, N Kriuchkova, A Averianov, E Manara, S Paolacci, A Bruson, R Miotto, M Sartori, G Guerri, M Zuntini, G Marceddu, S Tezzele, K Tadtaeva, A Chernova, N Aksyutina, S Nikulina, S Nodari, M Bertelli (2019). Putative role of Brugada syndrome genes in familial atrial fibrillation. European review for medical and pharmacological sciences, 7582-7598. https://doi.org/10.26355/eurrev_201909_18880 PMID: 31539150",
                    "31539150"
                ],
                [
                    "Xiuhua Bozarth, Jennifer N Dines, Qian Cong, Ghayda M Mirzaa, Kimberly Foss, J Lawrence Merritt, Jenny Thies, Heather C Mefford, Edward Novotny (2018). Expanding clinical phenotype in CACNA1C related disorders: From neonatal onset severe epileptic encephalopathy to late-onset epilepsy. American journal of medical genetics. Part A, 2733-2739. https://doi.org/10.1002/ajmg.a.40657 PMID: 30513141",
                    "30513141"
                ]
            ]
        ],
        [
            [
                "Brugada Syndrome",
                "PKP2"
            ],
            11.950596,
            [
                [
                    "Lorenzo Gigli, Simone Sala, Alberto Preda, Kenji Okubo, Giovanni Peretto, Antonio Frontera, Marisa Varrenti, Matteo Baroni, Marco Carbonaro, Sara Vargiu, Chiara Di Resta, Pasquale Striano, Patrizio Mazzone, Paolo Della Bella (2023). Electrocardiogram Changes in the Postictal Phase of Epileptic Seizure: Results from a Prospective Study. Journal of clinical medicine. https://doi.org/10.3390/jcm12124098 PMID: 37373791",
                    "37373791"
                ],
                [
                    "Hans Ebbinghaus, Laura Ueberham, Daniela Husser-Bollmann, Andreas Bollmann, Ulrich Laufs, Borislav Dinov (2023). Case Report: Four cases of cardiac sarcoidosis in patients with inherited cardiomyopathy-a phenotypic overlap, co-existence of two rare cardiomyopathies or a second-hit disease. Frontiers in cardiovascular medicine, 1328802. https://doi.org/10.3389/fcvm.2023.1328802 PMID: 38173816",
                    "38173816"
                ],
                [
                    "Simone Persampieri, Chiara Assunta Pilato, Elena Sommariva, Angela Serena Maione, Ilaria Stadiotti, Antonio Ranalletta, Margherita Torchio, Antonio Dello Russo, Cristina Basso, Giulio Pompilio, Claudio Tondo, Michela Casella (2020). Clinical and Molecular Data Define a Diagnosis of Arrhythmogenic Cardiomyopathy in a Carrier of a Brugada-Syndrome-Associated PKP2 Mutation. Genes. https://doi.org/10.3390/genes11050571 PMID: 32443836",
                    "32443836"
                ],
                [
                    "P E Maltese, E Aldanova, N Kriuchkova, A Averianov, E Manara, S Paolacci, A Bruson, R Miotto, M Sartori, G Guerri, M Zuntini, G Marceddu, S Tezzele, K Tadtaeva, A Chernova, N Aksyutina, S Nikulina, S Nodari, M Bertelli (2019). Putative role of Brugada syndrome genes in familial atrial fibrillation. European review for medical and pharmacological sciences, 7582-7598. https://doi.org/10.26355/eurrev_201909_18880 PMID: 31539150",
                    "31539150"
                ],
                [
                    "Marina Cerrone, Carol Ann Remme, Rafik Tadros, Connie R Bezzina, Mario Delmar (2019). Beyond the One Gene-One Disease Paradigm: Complex Genetics and Pleiotropy in Inheritable Cardiac Disorders Circulation, 595-610. https://doi.org/10.1161/CIRCULATIONAHA.118.035954 PMID: 31403841",
                    "31403841"
                ],
                [
                    "Valeria Novelli, Kabir Malkani, Marina Cerrone (2018). Pleiotropic Phenotypes Associated With PKP2 Variants. Frontiers in cardiovascular medicine, 184. https://doi.org/10.3389/fcvm.2018.00184 PMID: 30619891",
                    "30619891"
                ],
                [
                    "C M Mak, S Pl Chen, N S Mok, W K Siu, H Hc Lee, C K Ching, P T Tsui, N C Fong, Y P Yuen, W T Poon, C Y Law, Y K Chong, Y W Chan, T C Yung, K Yy Fan, C W Lam (2018). Genetic basis of channelopathies and cardiomyopathies in Hong Kong Chinese patients: a 10-year regional laboratory experience. Hong Kong medical journal = Xianggang yi xue za zhi, 340-349. https://doi.org/10.12809/hkmj176870 PMID: 29497013",
                    "29497013"
                ],
                [
                    "Lorenzo Gigli, Giovanni Bertero, Monica Coll Vidal, Anna Iglesias, Oscar Campuzano, Pasquale Striano, Antonio Oliva, Ramon Brugada (2017). Juvenile myoclonic epilepsy and Brugada type 1 ECG pattern associated with (a novel) plakophillin 2 mutation. Journal of neurology, 792-795. https://doi.org/10.1007/s00415-017-8414-2 PMID: 28220292",
                    "28220292"
                ],
                [
                    "Oscar Campuzano, Anna Fernández-Falgueras, Anna Iglesias, Ramon Brugada (2016). Brugada Syndrome and PKP2: Evidences and uncertainties. International journal of cardiology, 403-5. PMID: 27085656",
                    "27085656"
                ],
                [
                    "Lei Huang, Shuangbo Tang, Longyun Peng, Yili Chen, Jianding Cheng (2016). Molecular Autopsy of Desmosomal Protein Plakophilin-2 in Sudden Unexplained Nocturnal Death Syndrome. Journal of forensic sciences, 687-91. https://doi.org/10.1111/1556-4029.13027 PMID: 27122407",
                    "27122407"
                ]
            ]
        ],
        [
            [
                "Brugada Syndrome",
                "GPD1L"
            ],
            11.956566,
            [
                [
                    "Francesca Semino, Fabrice F Darche, Claus Bruehl, Michael Koenen, Heyko Skladny, Hugo A Katus, Norbert Frey, Andreas Draguhn, Patrick A Schweizer (2023). GPD1L-A306del modifies sodium current in a family carrying the dysfunctional SCN5A-G1661R mutation associated with Brugada syndrome. Pflugers Archiv : European journal of physiology. https://doi.org/10.1007/s00424-023-02882-0 PMID: 38036776",
                    "38036776"
                ],
                [
                    "Alexander M Greiner, Haider Mehdi, Chloe Cevan, Rebecca Gutmann, Barry London (2023). The role of GPD1L, a sodium channel interacting gene, in the pathogenesis of Brugada Syndrome. Frontiers in medicine, 1159586. https://doi.org/10.3389/fmed.2023.1159586 PMID: 38962240",
                    "38962240"
                ],
                [
                    "Meng Yuan, Yi Guo, Hong Xia, Hongbo Xu, Hao Deng, Lamei Yuan (2021). Novel SCN5A and GPD1L Variants Identified in Two Unrelated Han-Chinese Patients With Clinically Suspected Brugada Syndrome. Frontiers in cardiovascular medicine, 758903. https://doi.org/10.3389/fcvm.2021.758903 PMID: 34957250",
                    "34957250"
                ],
                [
                    "Richa Tambi, Reem Abdel Hameid, Asma Bankapur, Nasna Nassir, Ghausia Begum, Alawi Alsheikh-Ali, Mohammed Uddin, Bakhrom K Berdiev (2021). Single-cell transcriptomics trajectory and molecular convergence of clinically relevant mutations in Brugada syndrome. American journal of physiology. Heart and circulatory physiology, H1935-H1948. https://doi.org/10.1152/ajpheart.00061.2021 PMID: 33797273",
                    "33797273"
                ],
                [
                    "Houria Daimi, Amel Haj Khelil, Ali Neji, Khaldoun Ben Hamda, Sabri Maaoui, Amelia Aranega, Jemni Be Chibani, Diego Franco (2019). Role of SCN5A coding and non-coding sequences in Brugada syndrome onset: What's behind the scenes? Biomedical journal, 252-260. https://doi.org/10.1016/j.bj.2019.03.003 PMID: 31627867",
                    "31627867"
                ],
                [
                    "Hao Huang, Ya-Qin Chen, Liang-Liang Fan, Shuai Guo, Jing-Jing Li, Jie-Yuan Jin, Rong Xiang (2018). Whole-exome sequencing identifies a novel mutation of GPD1L (R189X) associated with familial conduction disease and sudden death. Journal of cellular and molecular medicine, 1350-1354. https://doi.org/10.1111/jcmm.13409 PMID: 29077258",
                    "29077258"
                ],
                [
                    "Can Hasdemir, Serdar Payzin, Umut Kocabas, Hatice Sahin, Nihal Yildirim, Alpay Alp, Mehmet Aydin, Ryan Pfeiffer, Elena Burashnikov, Yuesheng Wu, Charles Antzelevitch (2015). High prevalence of concealed Brugada syndrome in patients with atrioventricular nodal reentrant tachycardia. Heart rhythm, 1584-94. PMID: 25998140",
                    "25998140"
                ],
                [
                    "Catarina Allegue, Mònica Coll, Jesus Mates, Oscar Campuzano, Anna Iglesias, Beatriz Sobrino, Maria Brion, Jorge Amigo, Angel Carracedo, Pedro Brugada, Josep Brugada, Ramon Brugada (2015). Genetic Analysis of Arrhythmogenic Diseases in the Era of NGS: The Complexity of Clinical Decision-Making in Brugada Syndrome. PloS one, e0133037. https://doi.org/10.1371/journal.pone.0133037 PMID: 26230511",
                    "26230511"
                ],
                [
                    "Marina Cerrone, Xianming Lin, Mingliang Zhang, Esperanza Agullo-Pascual, Anna Pfenniger, Halina Chkourko Gusky, Valeria Novelli, Changsung Kim, Tiara Tirasawadichai, Daniel P Judge, Eli Rothenberg, Huei-Sheng Vincent Chen, Carlo Napolitano, Silvia G Priori, Mario Delmar (2014). Missense mutations in plakophilin-2 cause sodium current deficit and associate with a Brugada syndrome phenotype. Circulation, 1092-103. https://doi.org/10.1161/CIRCULATIONAHA.113.003077 PMID: 24352520",
                    "24352520"
                ],
                [
                    "Chao Liu, David J Tester, Yiding Hou, Wen Wang, Guoli Lv, Michael J Ackerman, Jonathan C Makielski, Jianding Cheng (2014). Is sudden unexplained nocturnal death syndrome in Southern China a cardiac sodium channel dysfunction disorder? Forensic science international, 38-45. PMID: 24529773",
                    "24529773"
                ]
            ]
        ],
        [
            [
                "Brugada Syndrome",
                "SCN3B"
            ],
            11.952122000000001,
            [
                [
                    "Sahib S Sarbjit-Singh, Samir W Hamaia, Christopher A Beaudoin, Christopher L-H Huang, Greg J Mellor, Antony P Jackson, Samantha C Salvage (2025). A novel SCN3B in-frame codon deletion in a Brugada syndrome patient: Implications for disrupted NaV1.5 function. Journal of molecular and cellular cardiology. https://doi.org/10.1016/j.yjmcc.2024.12.011 PMID: 39761910",
                    "39761910"
                ],
                [
                    "Jun Fan, Shao-Hua Wang, Li-Li Cao, Wei-Jie Li, Shao-Xi Sun, Shao-Ling Luo, Yi-Chao Pan, Wen-Liang Tan, Tian-Yuan Wu, Zhen Liu, Bing-Bo Yu (2024). Identification of a novel Scn3b mutation in a Chinese Brugada syndrome pedigree: implications for Nav1.5 electrophysiological properties and intracellular distribution of Nav1.5 and Navβ3. Frontiers in cardiovascular medicine, 1320687. https://doi.org/10.3389/fcvm.2024.1320687 PMID: 38450374",
                    "38450374"
                ],
                [
                    "Samantha C Salvage, Kamalan Jeevaratnam, Christopher L-H Huang, Antony P Jackson (2023). Cardiac sodium channel complexes and arrhythmia: structural and functional roles of the β1 and β3 subunits. The Journal of physiology, 923-940. https://doi.org/10.1113/JP283085 PMID: 36354758",
                    "36354758"
                ],
                [
                    "Shinichiro Okata, Shinsuke Yuasa, Tomoyuki Suzuki, Shogo Ito, Naomasa Makita, Tetsu Yoshida, Min Li, Junko Kurokawa, Tomohisa Seki, Toru Egashira, Yoshiyasu Aizawa, Masaki Kodaira, Chikaaki Motoda, Gakuto Yozu, Masaya Shimojima, Nozomi Hayashiji, Hisayuki Hashimoto, Yusuke Kuroda, Atsushi Tanaka, Mitsushige Murata, Takeshi Aiba, Wataru Shimizu, Minoru Horie, Kaichiro Kamiya, Tetsushi Furukawa, Keiichi Fukuda (2016). Embryonic type Na+ channel β-subunit, SCN3B masks the disease phenotype of Brugada syndrome. Scientific reports, 34198. https://doi.org/10.1038/srep34198 PMID: 27677334",
                    "27677334"
                ],
                [
                    "Uschi Peeters, Fabiana Scornik, Helena Riuró, Guillermo Pérez, Evrim Komurcu-Bayrak, Sophie Van Malderen, Gudrun Pappaert, Anna Tarradas, Sara Pagans, Dorien Daneels, Karine Breckpot, Pedro Brugada, Maryse Bonduelle, Ramon Brugada, Sonia Van Dooren (2015). Contribution of Cardiac Sodium Channel β-Subunit Variants to Brugada Syndrome. Circulation journal : official journal of the Japanese Circulation Society, 2118-29. https://doi.org/10.1253/circj.CJ-15-0164 PMID: 26179811",
                    "26179811"
                ],
                [
                    "Catarina Allegue, Mònica Coll, Jesus Mates, Oscar Campuzano, Anna Iglesias, Beatriz Sobrino, Maria Brion, Jorge Amigo, Angel Carracedo, Pedro Brugada, Josep Brugada, Ramon Brugada (2015). Genetic Analysis of Arrhythmogenic Diseases in the Era of NGS: The Complexity of Clinical Decision-Making in Brugada Syndrome. PloS one, e0133037. https://doi.org/10.1371/journal.pone.0133037 PMID: 26230511",
                    "26230511"
                ],
                [
                    "Chao Liu, David J Tester, Yiding Hou, Wen Wang, Guoli Lv, Michael J Ackerman, Jonathan C Makielski, Jianding Cheng (2014). Is sudden unexplained nocturnal death syndrome in Southern China a cardiac sodium channel dysfunction disorder? Forensic science international, 38-45. PMID: 24529773",
                    "24529773"
                ],
                [
                    "Jian-hua Yu, Jin-zhu Hu, Hui Zhou, Xin Liu, Qing Cao, Yang Shen, Jian-yong Ma, Sun-zhen Zhou, Xiu-xia Liu, Ju-xiang Li, Qi Chen, Xiao-shu Cheng, Kui Hong (2013). [SCN5A mutation in patients with Brugada electrocardiographic pattern induced by fever]. Zhonghua xin xue guan bing za zhi, 1010-4. PMID: 24524602",
                    "24524602"
                ],
                [
                    "Taisuke Ishikawa, Naohiko Takahashi, Seiko Ohno, Harumizu Sakurada, Kazufumi Nakamura, Young Keun On, Jeong Euy Park, Takeru Makiyama, Minoru Horie, Takuro Arimura, Naomasa Makita, Akinori Kimura (2013). Novel SCN3B mutation associated with brugada syndrome affects intracellular trafficking and function of Nav1.5. Circulation journal : official journal of the Japanese Circulation Society, 959-67. https://doi.org/10.1253/circj.cj-12-0995 PMID: 23257389",
                    "23257389"
                ],
                [
                    "Kazuya Kurakami, Kuniaki Ishii (2013). Is a novel SCN3B mutation commonly found in SCN5A-negative Brugada syndrome patients? Circulation journal : official journal of the Japanese Circulation Society, 900-1. https://doi.org/10.1253/circj.cj-13-0242 PMID: 23449374",
                    "23449374"
                ]
            ]
        ],
        [
            [
                "Brugada Syndrome",
                "SCN5A"
            ],
            14.260516,
            [
                [
                    "Roddy Walsh, John Mauleekoonphairoj, Isabella Mengarelli, Fernanda M Bosada, Arie O Verkerk, Karel van Duijvenboden, Yong Poovorawan, Wanwarang Wongcharoen, Boosamas Sutjaporn, Pharawee Wandee, Nitinan Chimparlee, Ronpichai Chokesuwattanaskul, Kornkiat Vongpaisarnsin, Piyawan Dangkao, Cheng-I Wu, Rafik Tadros, Ahmad S Amin, Krystien V V Lieve, Pieter G Postema, Maarten Kooyman, Leander Beekman, Dujdao Sahasatas, Montawatt Amnueypol, Rungroj Krittayaphong, Somchai Prechawat, Alisara Anannab, Pattarapong Makarawate, Tachapong Ngarmukos, Keerapa Phusanti, Gumpanart Veerakul, Zoya Kingsbury, Taksina Newington, Uma Maheswari, Mark T Ross, Andrew Grace, Pier D Lambiase, Elijah R Behr, Jean-Jacques Schott, Richard Redon, Julien Barc, Vincent M Christoffels, Arthur A M Wilde, Koonlawee Nademanee, Connie R Bezzina, Apichai Khongphatthanayothin (2025). A Rare Noncoding Enhancer Variant in SCN5A Contributes to the High Prevalence of Brugada Syndrome in Thailand. Circulation, 31-44. https://doi.org/10.1161/CIRCULATIONAHA.124.069041 PMID: 39391988",
                    "39391988"
                ],
                [
                    "Ioannis Doundoulakis, Luigi Pannone, Pedro Brugada, Carlo de Asmundis (2025). Reply to the Editor- Revisiting the prognostic role of SCN5A in Brugada syndrome. Heart rhythm, 281. https://doi.org/10.1016/j.hrthm.2024.06.023 PMID: 38906516",
                    "38906516"
                ],
                [
                    "Deni Kukavica, Alessandro Trancuccio, Andrea Mazzanti, Carlo Napolitano, Massimo Morini, Gianluca Pili, Mirella Memmi, Patrick Gambelli, Raffaella Bloise, Jannì Nastoli, Barbara Colombi, Alessio Guarracino, Maira Marino, Carlo Ceriotti, Paola Galimberti, Luca Ottaviano, Massimo Mantica, Silvia G Priori (2024). Nonmodifiable Risk Factors Predict Outcomes in Brugada Syndrome. Journal of the American College of Cardiology, 2087-2098. https://doi.org/10.1016/j.jacc.2024.07.037 PMID: 39387761",
                    "39387761"
                ],
                [
                    "Michael Litt, Rajat Deo (2024). Brugada Syndrome Risk Stratification: Selecting the Population of Interest. Journal of the American College of Cardiology, 2099-2101. https://doi.org/10.1016/j.jacc.2024.08.076 PMID: 39387765",
                    "39387765"
                ],
                [
                    "Mohammad Iqbal, Michael Aditya Lesmana, Iwan Cahyo Santosa Putra, Giky Karwiky, Chaerul Achmad, Hanna Goenawan, Mohammad Rizki Akbar, Arief Sjamsulaksan Kartasasmita (2024). Implications of Associated Atrial Fibrillation in Brugada Syndrome for Sudden Cardiac Death ‒ A Case Series Analysis. The American journal of case reports, e945005. https://doi.org/10.12659/AJCR.945005 PMID: 39449185",
                    "39449185"
                ],
                [
                    "Jack Jnani, Dorota Gruber, Tafadzwa Mtisi, Moussa Saleh, Bani M Azari (2024). Identification of a SCN5A Genetic Variant Associated With Type 1 Brugada Syndrome (BrS) in a Family. Cureus, e64883. https://doi.org/10.7759/cureus.64883 PMID: 39156269",
                    "39156269"
                ],
                [
                    "Hangping Fan, Jun Su, Xiaochen Wang, Hao Wang, Xianzhen Chen, Yaxun Sun, Chenyang Jiang, Ping Liang (2024). Generation of an induced pluripotent stem cell line from a Brugada syndrome patient carrying SCN5A/c.3118G>C mutation. Stem cell research, 103529. https://doi.org/10.1016/j.scr.2024.103529 PMID: 39121653",
                    "39121653"
                ],
                [
                    "Santiago Cadena-Ullauri, Patricia Guevara-Ramírez, Viviana A Ruiz-Pozo, Rafael Tamayo-Trujillo, Elius Paz-Cruz, Daniel Simancas-Racines, Rita Ibarra-Castillo, José Luis Laso-Bayas, Ana Karina Zambrano (2024). Genomic analysis of an Ecuadorian individual carrying an SCN5A rare variant. BMC cardiovascular disorders, 388. https://doi.org/10.1186/s12872-024-04049-w PMID: 39068398",
                    "39068398"
                ],
                [
                    "Ying-Chi Shen, Jen-Chueh Wu, Ting-Tse Lin, Kai-Chung Chang, Jen-Jen Su, Jyh-Ming Jimmy Juang (2024). Case Report: Lacosamide unmasking SCN5A-associated Brugada syndrome in a young female with epilepsy. Frontiers in cardiovascular medicine, 1406614. https://doi.org/10.3389/fcvm.2024.1406614 PMID: 38883985",
                    "38883985"
                ],
                [
                    "Virginnio M Proost, Maarten P van den Berg, Carol Ann Remme, Arthur A M Wilde (2023). SCN5A-1795insD founder variant: a unique Dutch experience spanning 7 decades. Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, 263-271. https://doi.org/10.1007/s12471-023-01799-8 PMID: 37474841",
                    "37474841"
                ]
            ]
        ],
        [
            [
                "Brugada Syndrome",
                "SCN1B"
            ],
            11.9905975,
            [
                [
                    "Zachary J Williams, Laura Beth Payne, Xiaobo Wu, Robert G Gourdie (2025). New focus on cardiac voltage-gated sodium channel β1 and β1B: Novel targets for treating and understanding arrhythmias? Heart rhythm, 181-191. https://doi.org/10.1016/j.hrthm.2024.06.029 PMID: 38908461",
                    "38908461"
                ],
                [
                    "Na Kyeong Park, Seong Woo Choi, Soon-Jung Park, JooHan Woo, Hyun Jong Kim, Woo Kyung Kim, Sung-Hwan Moon, Hun-Jun Park, Sung Joon Kim (2024). Requirement of β subunit for the reduced voltage-gated Na+ current of a Brugada syndrome patient having novel double missense mutation (p.A385T/R504T) of SCN5A. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 313-322. https://doi.org/10.4196/kjpp.2024.28.4.313 PMID: 38926839",
                    "38926839"
                ],
                [
                    "Samantha C Salvage, Kamalan Jeevaratnam, Christopher L-H Huang, Antony P Jackson (2023). Cardiac sodium channel complexes and arrhythmia: structural and functional roles of the β1 and β3 subunits. The Journal of physiology, 923-940. https://doi.org/10.1113/JP283085 PMID: 36354758",
                    "36354758"
                ],
                [
                    "Anil S Sarica, Serhat Bor, Mehmet N Orman, Hector Barajas-Martinez, Jyh-Ming Jimmy Juang, Charles Antzelevitch, Can Hasdemir (2021). Frequency of Irritable Bowel Syndrome in Patients with Brugada Syndrome and Drug-Induced Type 1 Brugada Pattern. The American journal of cardiology, 51-56. https://doi.org/10.1016/j.amjcard.2021.04.010 PMID: 34034907",
                    "34034907"
                ],
                [
                    "Wei Shan, Guipeng An, Qian Ren, Qun Wang (2021). Generation of SCN1B knock out induced pluripotent stem cell (iPSC) line (refractory epilepsy syndrome and Brugada syndrome related cell line). Stem cell research, 102545. https://doi.org/10.1016/j.scr.2021.102545 PMID: 34583279",
                    "34583279"
                ],
                [
                    "Yue Zhu, Linlin Wang, Chang Cui, Huiyuan Qin, Hongwu Chen, Shaojie Chen, Yongping Lin, Hongyi Cheng, Xiaohong Jiang, Minglong Chen (2021). Pathogenesis and drug response of iPSC-derived cardiomyocytes from two Brugada syndrome patients with different Na v1.5-subunit mutations. Journal of biomedical research, 395-407. https://doi.org/10.7555/JBR.35.20210045 PMID: 34628405",
                    "34628405"
                ],
                [
                    "Linlin Wang, Zhonglin Han, Jian Dai, Kejiang Cao (2020). Brugada Syndrome Caused by Sodium Channel Dysfunction Associated with a SCN1B Variant A197V. Archives of medical research, 245-253. https://doi.org/10.1016/j.arcmed.2020.02.003 PMID: 32192759",
                    "32192759"
                ],
                [
                    "Hisham Al-Ward, Chun-Yang Liu, Ning Liu, Fahmi Shaher, Murad Al-Nusaif, Jing Mao, Hui Xu (2020). Voltage-Gated Sodium Channel β1 Gene: An Overview. Human heredity, 101-109. https://doi.org/10.1159/000516388 PMID: 34038903",
                    "34038903"
                ],
                [
                    "Kenneth A Myers, Michael I Shevell, Guillaume Sébire (2019). Sudden unexpected death in GEFS+ families with sodium channel pathogenic variants. Epilepsy research, 66-69. https://doi.org/10.1016/j.eplepsyres.2019.01.009 PMID: 30660056",
                    "30660056"
                ],
                [
                    "Ibrahim El-Battrawy, Jonas Müller, Zhihan Zhao, Lukas Cyganek, Rujia Zhong, Feng Zhang, Mandy Kleinsorge, Huan Lan, Xin Li, Qiang Xu, Mengying Huang, Zhenxing Liao, Alexander Moscu-Gregor, Sebastian Albers, Hendrik Dinkel, Siegfried Lang, Sebastian Diecke, Wolfram-Hubertus Zimmermann, Jochen Utikal, Thomas Wieland, Martin Borggrefe, Xiaobo Zhou, Ibrahim Akin (2019). Studying Brugada Syndrome With an SCN1B Variants in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Frontiers in cell and developmental biology, 261. https://doi.org/10.3389/fcell.2019.00261 PMID: 31737628",
                    "31737628"
                ]
            ]
        ]
    ]
}