{
    "nodes": [
        [
            "Migraine Disorders",
            "DISEASE"
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            "DISEASE"
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            "DISEASE"
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            "DISEASE"
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        [
            "CGRP",
            "GENE"
        ],
        [
            "Overactive Bladder",
            "DISEASE"
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        [
            [
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                [
                    "Jessica Ailani, Anjana Lalla, Rashmi B Halker Singh, Dagny Holle-Lee, Krisztian Nagy, Kari Kelton, Cristiano Piron, Pranav Gandhi, Patricia Pozo-Rosich (2024). Benefit-risk assessment based on number needed to treat and number needed to harm: Atogepant vs. calcitonin gene-related peptide monoclonal antibodies. Cephalalgia : an international journal of headache, 3331024241299377. https://doi.org/10.1177/03331024241299377 PMID: 39558612",
                    "39558612"
                ],
                [
                    "Anjaneya Shankar Madhav Bandatmakur, Pooja Dave, Melissa Kerr, Colin Brunick, Sijin Wen, Nicholas Hansen (2024). Effectiveness and Tolerability of Anti-Calcitonin Gene-Related Peptide Therapy for Migraine and Other Chronic Headaches in Adolescents and Young Adults: A Retrospective Study in the USA. Brain sciences. https://doi.org/10.3390/brainsci14090879 PMID: 39335375",
                    "39335375"
                ],
                [
                    "Sarah Stuart, Stephanie Gregg, Sally Ware, Prut Koonalintip, Benjamin R Wakerley (2024). Patient-completed online \"follow-up form\" to assess continuation of anti-CGRP(r) antibody therapy in patients with chronic migraine: A pilot project. Clinical neurology and neurosurgery, 108594. https://doi.org/10.1016/j.clineuro.2024.108594 PMID: 39481344",
                    "39481344"
                ],
                [
                    "Richard B Lipton (2024). Preventive Treatment of Migraine. Continuum (Minneapolis, Minn.), 364-378. https://doi.org/10.1212/CON.0000000000001418 PMID: 38568488",
                    "38568488"
                ],
                [
                    "Sawsan Alabbad, Nathalia Figueredo, Hsiangkuo Yuan, Stephen Silberstein (2024). Developments in targeting calcitonin gene-related peptide. Expert review of neurotherapeutics, 477-485. https://doi.org/10.1080/14737175.2024.2332754 PMID: 38557226",
                    "38557226"
                ],
                [
                    "Renato Oliveira, Raquel Gil-Gouveia, Francesca Puledda (2024). CGRP-targeted medication in chronic migraine - systematic review. The journal of headache and pain, 51. https://doi.org/10.1186/s10194-024-01753-y PMID: 38575868",
                    "38575868"
                ],
                [
                    "Abdulrahim Saleh Alrasheed, Taif Mansour Almaqboul, Reem Ali Alshamrani, Noor Mohammad AlMohish, Majed Mohammad Alabdali (2024). Safety and Efficacy of Atogepant for the Preventive Treatment of Migraines in Adults: A Systematic Review and Meta-Analysis. Journal of clinical medicine. https://doi.org/10.3390/jcm13226713 PMID: 39597856",
                    "39597856"
                ],
                [
                    "Jessica Ailani, Richard B Lipton, Andrew M Blumenfeld, Laszlo Mechtler, Brad C Klein, Molly Yizeng He, Jonathan H Smith, Joel M Trugman, Rosa de Abreu Ferreira, Elimor Brand-Schieber (2024). Safety and tolerability of ubrogepant for the acute treatment of migraine in participants taking atogepant for the preventive treatment of episodic migraine: Results from the TANDEM study. Headache. https://doi.org/10.1111/head.14871 PMID: 39569702",
                    "39569702"
                ],
                [
                    "Selia Chowdhury, Tirth Dave (2023). Novel Oral CGRP Receptor Antagonist Atogepant in the Prevention of Migraine. Discoveries (Craiova, Romania), e167. https://doi.org/10.15190/d.2023.6 PMID: 37564925",
                    "37564925"
                ],
                [
                    "Sena Uzun, Ulf Frejvall, Gülsen Özkaya-Sahin, Gürdal Sahin (2023). A case report of a chronic migraine patient treated with three different anti-CGRP monoclonal antibodies: which parameters better represent the efficacy? Frontiers in neurology, 1176816. https://doi.org/10.3389/fneur.2023.1176816 PMID: 37213912",
                    "37213912"
                ]
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                    "Agustin Melo-Carrillo, Andrew M Strassman, Khrystoffer-Kihan J Malcolm, Aubrey Manack Adams, Brett Dabruzzo, Ron S Briode, Mitchell F Brin, Rami Burstein (2024). Exploring the effects of extracranial injections of botulinum toxin type A on activation and sensitization of central trigeminovascular neurons by cortical spreading depression in male and female rats. Cephalalgia : an international journal of headache, 3331024241278919. https://doi.org/10.1177/03331024241278919 PMID: 39252510",
                    "39252510"
                ],
                [
                    "Fatemeh Farham, Dilara Onan, Paolo Martelletti (2024). Non-Migraine Head Pain and Botulinum Toxin. Toxins. https://doi.org/10.3390/toxins16100431 PMID: 39453207",
                    "39453207"
                ],
                [
                    "Grace Forde, Benjamin M Brucker, Kimberly Becker Ifantides, Atul T Patel, Angeli Mayadev, Theodore Brown, Ziyad Ayyoub, Kenneth Martinez, Ritu Singh, Mariana Nelson, Simona Battucci, Irina Yushmanova, Ahunna Ukah, Christopher Rhyne (2024). SYNCHRONIZE: Real-World Retrospective Safety Analysis of Patients Treated with OnabotulinumtoxinA for More than One Therapeutic Indication. Toxins. https://doi.org/10.3390/toxins16100420 PMID: 39453196",
                    "39453196"
                ],
                [
                    "Alex Jaimes, Andrea Gómez, Olga Pajares, Jaime Rodríguez-Vico (2024). OnabotulinumtoxinA as a promising treatment for primary trochlear headache: A retrospective case series. Headache, 589-594. https://doi.org/10.1111/head.14699 PMID: 38533675",
                    "38533675"
                ],
                [
                    "Matthew Robbins (2024). New Daily Persistent Headache. Continuum (Minneapolis, Minn.), 425-437. https://doi.org/10.1212/CON.0000000000001398 PMID: 38568492",
                    "38568492"
                ],
                [
                    "Hema Mistry, Seyran Naghdi, Anna Brown, Sophie Rees, Jason Madan, Amy Grove, Saval Khanal, Callum Duncan, Manjit Matharu, Andrew Cooklin, Aiva Aksentyte, Natasha Davies, Martin Underwood (2024). Preventive drug treatments for adults with chronic migraine: a systematic review with economic modelling. Health technology assessment (Winchester, England), 1-329. https://doi.org/10.3310/AYWA5297 PMID: 39365169",
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                ],
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                    "Seyran Naghdi, Martin Underwood, Anna Brown, Manjit Matharu, Callum Duncan, Natasha Davies, Aiva Aksentyte, Hema Mistry (2024). Adverse and serious adverse events incidence of pharmacological interventions for managing chronic and episodic migraine in adults: a systematic review. BMJ neurology open, e000616. https://doi.org/10.1136/bmjno-2023-000616 PMID: 38646505",
                    "38646505"
                ],
                [
                    "Fanyi Kong, Dawn C Buse, Guoliang Zhu, Jingjing Xu (2024). Comparative efficacy and safety of different pharmacological therapies to medication overuse headache: a network meta-analysis. The journal of headache and pain, 168. https://doi.org/10.1186/s10194-024-01878-0 PMID: 39375607",
                    "39375607"
                ],
                [
                    "Richard N Miller, Monica E Kim, Muhammed Talha Gunduz, Shawn C Aylward (2024). Advancements in pediatric headache. Current opinion in pediatrics, 624-629. https://doi.org/10.1097/MOP.0000000000001412 PMID: 39400079",
                    "39400079"
                ],
                [
                    "Marvin Thepsoparn, Prakit Anukoolwittaya, Patcharapol Toeypromthong, Chanon Thanaboriboon (2024). Efficacy and safety profile of Onabotulinum toxin-A injection at sphenopalatine ganglion in trigeminal neuralgia: a prospective observational study. The journal of headache and pain, 210. https://doi.org/10.1186/s10194-024-01926-9 PMID: 39623300",
                    "39623300"
                ]
            ]
        ],
        [
            [
                "CGRP",
                "Headache"
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                    "E Pons-Fuster, O Lozano-Caballero, S Martín-Balbuena, C Lucas-Ródenas, A Mancebo-González, I De Gorostiza-Frías, C M González-Ponce (2024). Anti‑CGRP monoclonal antibodies in resistant migraine: preliminary real-world effectiveness and clinical predictors of response at two years. International journal of clinical pharmacy, 1317-1326. https://doi.org/10.1007/s11096-024-01758-2 PMID: 38990457",
                    "38990457"
                ],
                [
                    "Lanfranco Pellesi, Messoud Ashina, Paolo Martelletti (2024). Targeting the PACAP-38 pathway is an emerging therapeutic strategy for migraine prevention. Expert opinion on emerging drugs, 57-64. https://doi.org/10.1080/14728214.2024.2317778 PMID: 38337150",
                    "38337150"
                ],
                [
                    "Marta Pascual-Mato, Gabriel Gárate, Vicente González-Quintanilla, Jorge Madera-Fernández, Beatriz Castro, María José García, Javier Crespo, Montserrat Rivero, Julio Pascual (2024). Differences in circulating alpha-calcitonin gene-related peptide levels in inflammatory bowel disease and its relation to migraine comorbidity: A cross-sectional study. Headache, 849-858. https://doi.org/10.1111/head.14768 PMID: 38922858",
                    "38922858"
                ],
                [
                    "Fatemeh Farham, Dilara Onan, Paolo Martelletti (2024). Non-Migraine Head Pain and Botulinum Toxin. Toxins. https://doi.org/10.3390/toxins16100431 PMID: 39453207",
                    "39453207"
                ],
                [
                    "Xiaoxin Wang, Yan Sun, Yuan Zhang, Zhaohui Zhi, Shilin Wang, Jiaohui Li, Yingzhe Sun, Yuanzheng Sun (2024). Research trends and hotspots in clinical trials of migraine in the past 20 years: bibliometric analysis. Frontiers in neurology, 1430138. https://doi.org/10.3389/fneur.2024.1430138 PMID: 39524909",
                    "39524909"
                ],
                [
                    "Nazia Karsan, Lars Edvinsson, Laszlo Vecsei, Peter J Goadsby (2024). Pituitary cyclase-activating polypeptide targeted treatments for the treatment of primary headache disorders. Annals of clinical and translational neurology, 1654-1668. https://doi.org/10.1002/acn3.52119 PMID: 38887982",
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                [
                    "Prakit Anukoolwittaya, Akarin Hiransuthikul, Thanakit Pongpitakmetha, Sekh Thanprasertsuk, Wanakorn Rattanawong (2024). Filling the data gap on CGRP mAb therapy in low- to middle-income countries in Southeast Asia: insights from a real-world study in Thailand. The journal of headache and pain, 150. https://doi.org/10.1186/s10194-024-01859-3 PMID: 39267011",
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                    "Pablo Irimia, Sonia Santos-Lasaosa, Patricia Pozo-Rosich, Rogelio Leira, Julio Pascual, José Miguel Láinez (2024). Eptinezumab for the preventive treatment of episodic and chronic migraine: a narrative review. Frontiers in neurology, 1355877. https://doi.org/10.3389/fneur.2024.1355877 PMID: 38523607",
                    "38523607"
                ],
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                    "Seyran Naghdi, Martin Underwood, Anna Brown, Manjit Matharu, Callum Duncan, Natasha Davies, Aiva Aksentyte, Hema Mistry (2024). Adverse and serious adverse events incidence of pharmacological interventions for managing chronic and episodic migraine in adults: a systematic review. BMJ neurology open, e000616. https://doi.org/10.1136/bmjno-2023-000616 PMID: 38646505",
                    "38646505"
                ],
                [
                    "Teddy Hervias (2024). An update on migraine: Current and new treatment options. JAAPA : official journal of the American Academy of Physician Assistants, 1-7. https://doi.org/10.1097/01.JAA.0000000000000014 PMID: 38662902",
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                    "Elena Cresta, Alessia Bellotti, Giovanni Rinaldi, Ilenia Corbelli, Paola Sarchielli (2024). Effect of anti-CGRP-targeted therapy on migraine aura: Results of an observational case series study. CNS neuroscience & therapeutics, e14595. https://doi.org/10.1111/cns.14595 PMID: 38332541",
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                    "Carlos Lazaro-Hernandez, Edoardo Caronna, Joana Rosell-Mirmi, Victor J Gallardo, Alicia Alpuente, Marta Torres-Ferrus, Patricia Pozo-Rosich (2024). Early and annual projected savings from anti-CGRP monoclonal antibodies in migraine prevention: a cost-benefit analysis in the working-age population. The journal of headache and pain, 21. https://doi.org/10.1186/s10194-024-01727-0 PMID: 38347485",
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                    "Seyran Naghdi, Martin Underwood, Anna Brown, Manjit Matharu, Callum Duncan, Natasha Davies, Aiva Aksentyte, Hema Mistry (2024). Adverse and serious adverse events incidence of pharmacological interventions for managing chronic and episodic migraine in adults: a systematic review. BMJ neurology open, e000616. https://doi.org/10.1136/bmjno-2023-000616 PMID: 38646505",
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                [
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        [
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        ],
        [
            [
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                ]
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        [
            [
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                "Headache"
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                    "E Pons-Fuster, O Lozano-Caballero, S Martín-Balbuena, C Lucas-Ródenas, A Mancebo-González, I De Gorostiza-Frías, C M González-Ponce (2024). Anti‑CGRP monoclonal antibodies in resistant migraine: preliminary real-world effectiveness and clinical predictors of response at two years. International journal of clinical pharmacy, 1317-1326. https://doi.org/10.1007/s11096-024-01758-2 PMID: 38990457",
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                ],
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                ],
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}