{
    "nodes": [
        [
            "calcitonin gene-related peptide",
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                [
                    "Lauren Powell, Fiona O'Sullivan, Pramoda Jayasinghe, Basia Rogula, Feng Dai, Jessica Cirillo, Samantha Sweeney, Lucy Abraham, Jessica Ailani (2025). Reduction of pain and functional disability over time in patients treated with zavegepant: a post-hoc analysis of the BHV3500-301 phase 3 randomized controlled trial. The journal of headache and pain, 1. https://doi.org/10.1186/s10194-024-01915-y PMID: 39748312",
                    "39748312"
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                [
                    "Davide Para, Chiara Camponovo, Gianna Carla Riccitelli, Giulia Mallucci, Paolo Maino, Camilla Mondini Trissino da Lodi, Demurtas Saudina, Pierpaolo Trimboli, Claudio Gobbi, Chiara Zecca (2024). Assessment of Bone Mineral Density Over 1 Year in a Cross-Sectional Cohort of Migraine Patients Receiving Anti-CGRP Monoclonal Antibodies. CNS drugs, 819-825. https://doi.org/10.1007/s40263-024-01104-0 PMID: 39174745",
                    "39174745"
                ],
                [
                    "Lanfranco Pellesi, Dilara Onan, Paolo Martelletti (2024). Onabotulinumtoxin A for the Treatment of Post-Traumatic Headache: Is It Better than Anti-CGRP Antibodies? Toxins. https://doi.org/10.3390/toxins16100427 PMID: 39453203",
                    "39453203"
                ],
                [
                    "Richard B Lipton (2024). Preventive Treatment of Migraine. Continuum (Minneapolis, Minn.), 364-378. https://doi.org/10.1212/CON.0000000000001418 PMID: 38568488",
                    "38568488"
                ],
                [
                    "Adam B Willits, Leena Kader, Olivia Eller, Emily Roberts, Bailey Bye, Taylor Strope, Bret D Freudenthal, Shahid Umar, Sree Chintapalli, Kartik Shankar, Dong Pei, Julie Christianson, Kyle M Baumbauer, Erin E Young (2024). Spinal cord injury-induced neurogenic bowel: A role for host-microbiome interactions in bowel pain and dysfunction. Neurobiology of pain (Cambridge, Mass.), 100156. https://doi.org/10.1016/j.ynpai.2024.100156 PMID: 38601267",
                    "38601267"
                ],
                [
                    "Grazia Dell Agnello, Carlotta Buzzoni, Amalia Antenori, Federico Torelli, Claudia Altamura, Fabrizio Vernieri (2023). Galcanezumab in the Treatment of Migraine: A Narrative Review of Real-World Studies. Clinical neuropharmacology, 220-228. https://doi.org/10.1097/WNF.0000000000000571 PMID: 37962309",
                    "37962309"
                ],
                [
                    "Christian Lampl, Antoinette MaassenVanDenBrink, Christina I Deligianni, Raquel Gil-Gouveia, Tanvir Jassal, Margarita Sanchez-Del-Rio, Uwe Reuter, Derya Uluduz, Jan Versijpt, Dena Zeraatkar, Simona Sacco (2023). The comparative effectiveness of migraine preventive drugs: a systematic review and network meta-analysis. The journal of headache and pain, 56. https://doi.org/10.1186/s10194-023-01594-1 PMID: 37208596",
                    "37208596"
                ],
                [
                    "Alicia Gonzalez-Martinez, Ancor Sanz-García, David García-Azorín, Jaime Samuel Rodriguez-Vico, Alex Jaimes, Andrea Gómez García, Javier Casas Limón, Javier Díaz de Terán, María Sastre-Real, Javier Membrilla, Germán Latorre, Carlos Calle de Miguel, Sendoa Gil Luque, Cristina Trevino-Peinado, Sonia Quintas, Patricia Heredia, Ana Echavarría Íñiguez, Ángel Guerrero-Peral, Álvaro Sierra, Nuria González-García, Jesús Porta-Etessam, Ana Beatriz Gago-Veiga (2023). Effectiveness, tolerability and response predictors of preventive anti-CGRP mAbs for migraine in patients over 65 years old: a multicenter real-world case-control study. Pain medicine (Malden, Mass.). https://doi.org/10.1093/pm/pnad141 PMID: 37847661",
                    "37847661"
                ],
                [
                    "Daisuke Watabe, Mitsutoshi Tominaga, Sumika Toyama, Kenji Takamori, Hajime Nakano, Hiroo Amano (2023). A severe case of primary erythromelalgia presenting as small fiber neuropathy with a novel SCN9A mutation. The Journal of dermatology, 938-941. https://doi.org/10.1111/1346-8138.16754 PMID: 36815391",
                    "36815391"
                ],
                [
                    "Changqing Mei, Chen Pan, Linbin Xu, Mengmeng Miao, Qichen Lu, Yang Yu, Pengyu Lin, Wenwei Wu, Feng Ni, Yinping Gao, Yuhao Xu, Jia Xu, Xiaowei Chen (2023). Trimethoxyflavanone relieves Paclitaxel-induced neuropathic pain via inhibiting expression and activation of P2X7 and production of CGRP in mice. Neuropharmacology, 109584. https://doi.org/10.1016/j.neuropharm.2023.109584 PMID: 37225085",
                    "37225085"
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                [
                    "Patrick Eugeni, Megan E Rooney, Nicolas P Saikali, Zhongzheng Niu, Maurice T Driessen, Lynda J Krasenbaum, Karen Carr, Michael J Seminerio, Jennifer W McVige (2025). US Real-World Effectiveness, Tolerability, and Healthcare Resource Utilization After Addition of Fremanezumab for Preventive Treatment in Patients Using Gepants for Acute Treatment of Migraine: Results From a Retrospective Chart Review. Advances in therapy. https://doi.org/10.1007/s12325-024-03063-w PMID: 39775579",
                    "39775579"
                ],
                [
                    "Luigi Francesco Iannone, Gloria Vaghi, Gabriele Sebastianelli, Francesco Casillo, Antonio Russo, Marcello Silvestro, Francesca Pistoia, Giorgio Dalla Volta, Matteo Cortinovis, Alberto Chiarugi, Danilo Antonio Montisano, Maria Pia Prudenzano, Sabina Cevoli, Edoardo Mampreso, Gianluca Avino, Marina Romozzi, Mariarosaria Valente, Carla Fasano, Stefania Battistini, Antonio Granato, Elisa Maria Piella, Innocenzo Rainero, Raffaele Ornello, Roberto De Icco,   (2025). Effectiveness and tolerability of rimegepant in the acute treatment of migraine: a real-world, prospective, multicentric study (GAINER study). The journal of headache and pain, 4. https://doi.org/10.1186/s10194-024-01935-8 PMID: 39762740",
                    "39762740"
                ],
                [
                    "Samaira Younis, Nina V Latysheva, Alexey B Danilov, Messoud Ashina (2024). CGRP receptor antagonists (gepants). Handbook of clinical neurology, 51-66. https://doi.org/10.1016/B978-0-12-823357-3.00033-1 PMID: 38307667",
                    "38307667"
                ],
                [
                    "Tessa de Vries, Eloísa Rubio-Beltrán, Antoon van den Bogaerdt, Ruben Dammers, A H Jan Danser, Josefin Snellman, Jeanine Bussiere, Antoinette MaassenVanDenBrink (2024). Pharmacology of erenumab in human isolated coronary and meningeal arteries: Additional effect of gepants on top of a maximum effect of erenumab. British journal of pharmacology, 1720-1733. https://doi.org/10.1111/bph.16322 PMID: 38320397",
                    "38320397"
                ],
                [
                    "Yiya Zhang, Tao Li, Han Zhao, Xin Xiao, Ximin Hu, Ben Wang, Yingxue Huang, Zhinan Yin, Yun Zhong, Yangfan Li, Ji Li (2024). High-sensitive sensory neurons exacerbate rosacea-like dermatitis in mice by activating γδ T cells directly. Nature communications, 7265. https://doi.org/10.1038/s41467-024-50970-1 PMID: 39179539",
                    "39179539"
                ],
                [
                    "Frank Porreca, Edita Navratilova, Joe Hirman, Antoinette Maassen van den Brink, Richard B Lipton, David W Dodick (2024). Evaluation of outcomes of calcitonin gene-related peptide (CGRP)-targeting therapies for acute and preventive migraine treatment based on patient sex. Cephalalgia : an international journal of headache, 3331024241238153. https://doi.org/10.1177/03331024241238153 PMID: 38477313",
                    "38477313"
                ],
                [
                    "Lanfranco Pellesi, Paolo Martelletti (2024). Situational prevention in migraine: are we doing the right thing? The journal of headache and pain, 137. https://doi.org/10.1186/s10194-024-01841-z PMID: 39174943",
                    "39174943"
                ],
                [
                    "Robert Croop, Gary Berman, David Kudrow, Kathleen Mullin, Alexandra Thiry, Meghan Lovegren, Gilbert L'Italien, Richard B Lipton (2024). A multicenter, open-label long-term safety study of rimegepant for the acute treatment of migraine. Cephalalgia : an international journal of headache, 3331024241232944. https://doi.org/10.1177/03331024241232944 PMID: 38659334",
                    "38659334"
                ],
                [
                    "Ryan Thaliffdeen, Anthony Yu, Karen Rascati (2024). Cost-Effectiveness Evaluation of Oral CGRP Antagonists, Atogepant and Rimegepant, for the Preventative Treatment of Episodic Migraine: Results from a US Societal Perspective Model. Clinical drug investigation, 209-217. https://doi.org/10.1007/s40261-024-01345-3 PMID: 38381352",
                    "38381352"
                ],
                [
                    "Richard B Lipton (2024). Preventive Treatment of Migraine. Continuum (Minneapolis, Minn.), 364-378. https://doi.org/10.1212/CON.0000000000001418 PMID: 38568488",
                    "38568488"
                ]
            ]
        ],
        [
            [
                "Migraine",
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            [
                [
                    "Lulu Zhang, Jia Xu, Jiejie Guo, Yun Wang, Qinwen Wang (2023). Elucidation of Pharmacological Mechanism Underlying the Anti-Alzheimer's Disease Effects of Evodia rutaecarpa and Discovery of Novel Lead Molecules: An In Silico Study. Molecules (Basel, Switzerland). https://doi.org/10.3390/molecules28155846 PMID: 37570816",
                    "37570816"
                ],
                [
                    "Sawan Kumar, Jyotdeep Kour Raina, Amrit Sudershan, Kanak Mahajan, Raman Jasrotia, Chinmoyee Maharana, Rakesh K Panjalia, Parvinder Kumar (2023). An Association Study of ESR1-XbaI and PvuII Gene Polymorphism in Migraine Susceptibility in the Jammu Region. European neurology, 55-62. https://doi.org/10.1159/000527271 PMID: 36436502",
                    "36436502"
                ],
                [
                    "Diogo Cruz, Francisca Monteiro, Maria Paço, Manuel Vaz-Silva, Carolina Lemos, Miguel Alves-Ferreira, Teresa Pinho (2022). Genetic overlap between temporomandibular disorders and primary headaches: A systematic review. The Japanese dental science review, 69-88. https://doi.org/10.1016/j.jdsr.2022.02.002 PMID: 35242249",
                    "35242249"
                ],
                [
                    "Rita De Sanctis, Alessandro Viganò, Sebastiano Pindilli, Rosalba Torrisi, Armando Santoro (2022). A pilot analysis of headache disorders in breast cancer patients. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 3313-3320. https://doi.org/10.1007/s10072-021-05698-x PMID: 34817729",
                    "34817729"
                ],
                [
                    "Philippa T K Saunders (2022). Insights from genomic studies on the role of sex steroids in the aetiology of endometriosis. Reproduction & fertility, R51-R65. https://doi.org/10.1530/RAF-21-0078 PMID: 35514537",
                    "35514537"
                ],
                [
                    "Joy-Fleur van der Vaart, Gabriele Susanne Merki-Feld (2022). Sex hormone-related polymorphisms in endometriosis and migraine: A narrative review. Women's health (London, England), 17455057221111315. https://doi.org/10.1177/17455057221111315 PMID: 35848345",
                    "35848345"
                ],
                [
                    "Avery K Olson, Keith A Hansen (2021). Menstrual Migraines: Diagnosis, Evidence, and Treatment. South Dakota medicine : the journal of the South Dakota State Medical Association, 570-575. PMID: 35015948",
                    "35015948"
                ],
                [
                    "Divya Goel, Kaiser Un Nisa, Mohammad Irshad Reza, Ziaur Rahman, Shaikh Aamer (2019). Aberrant DNA Methylation Pattern may Enhance Susceptibility to Migraine: A Novel Perspective. CNS & neurological disorders drug targets, 504-515. https://doi.org/10.2174/1871527318666190809162631 PMID: 31400273",
                    "31400273"
                ],
                [
                    "Alexander J Sandweiss, Karissa E Cottier, Mary I McIntosh, Gregory Dussor, Thomas P Davis, Todd W Vanderah, Tally M Largent-Milnes (2017). 17-β-Estradiol induces spreading depression and pain behavior in alert female rats. Oncotarget, 114109-114122. https://doi.org/10.18632/oncotarget.23141 PMID: 29371973",
                    "29371973"
                ],
                [
                    "Xingkai An, Jie Fang, Qing Lin, Congxia Lu, Qilin Ma, Hongli Qu (2017). New evidence for involvement of ESR1 gene in susceptibility to Chinese migraine. Journal of neurology, 81-87. https://doi.org/10.1007/s00415-016-8321-y PMID: 27778160",
                    "27778160"
                ]
            ]
        ],
        [
            [
                "CGRP",
                "Migraine"
            ],
            61.064243,
            [
                [
                    "Sajjad Jabbari, Zainul Amiruddin Zakaria, Irwin Rose Alencar de Menezes, Saeed Mohammadi (2025). Antinociceptive, antineuropathic, and antimigraine-like activities ofFritillariaimperialis L. rich in verticinone on rats: Mechanisms of action. Journal of ethnopharmacology, 119174. https://doi.org/10.1016/j.jep.2024.119174 PMID: 39613005",
                    "39613005"
                ],
                [
                    "Lauren Powell, Fiona O'Sullivan, Pramoda Jayasinghe, Basia Rogula, Feng Dai, Jessica Cirillo, Samantha Sweeney, Lucy Abraham, Jessica Ailani (2025). Reduction of pain and functional disability over time in patients treated with zavegepant: a post-hoc analysis of the BHV3500-301 phase 3 randomized controlled trial. The journal of headache and pain, 1. https://doi.org/10.1186/s10194-024-01915-y PMID: 39748312",
                    "39748312"
                ],
                [
                    "Davide Para, Chiara Camponovo, Gianna Carla Riccitelli, Giulia Mallucci, Paolo Maino, Camilla Mondini Trissino da Lodi, Demurtas Saudina, Pierpaolo Trimboli, Claudio Gobbi, Chiara Zecca (2024). Assessment of Bone Mineral Density Over 1 Year in a Cross-Sectional Cohort of Migraine Patients Receiving Anti-CGRP Monoclonal Antibodies. CNS drugs, 819-825. https://doi.org/10.1007/s40263-024-01104-0 PMID: 39174745",
                    "39174745"
                ],
                [
                    "Yao Zhang, Fei Ge, Yamin Luo, Xuenian Ji, Zijian Liu, Yuehua Qiu, Jianchen Hou, Ranran Zhou, Caihong Zhao, Qianwei Xu, Shujing Zhang, Xue Yu, Chunguo Wang, Dongyu Ge, Fengxian Meng, Xiaohua Tao (2024). Paeonol and glycyrrhizic acid in combination ameliorate the recurrent nitroglycerin-induced migraine-like phenotype in rats by regulating the GABBR2/TRPM8/PRKACA/TRPV1 pathway. Journal of ethnopharmacology, 118464. https://doi.org/10.1016/j.jep.2024.118464 PMID: 38908492",
                    "38908492"
                ],
                [
                    "E Pons-Fuster, O Lozano-Caballero, S Martín-Balbuena, C Lucas-Ródenas, A Mancebo-González, I De Gorostiza-Frías, C M González-Ponce (2024). Anti‑CGRP monoclonal antibodies in resistant migraine: preliminary real-world effectiveness and clinical predictors of response at two years. International journal of clinical pharmacy, 1317-1326. https://doi.org/10.1007/s11096-024-01758-2 PMID: 38990457",
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                ],
                [
                    "Richard B Lipton, Stephanie J Nahas, Patricia Pozo-Rosich, Tanya Bilchik, Peter McAllister, Michelle Finnegan, Yingyi Liu, Natty Chalermpalanupap, Brett Dabruzzo, David W Dodick (2024). Sustained response to atogepant in episodic migraine: post hoc analyses of a 12-week randomized trial and a 52-week long-term safety trial. The journal of headache and pain, 83. https://doi.org/10.1186/s10194-024-01783-6 PMID: 38773375",
                    "38773375"
                ],
                [
                    "Lanfranco Pellesi, Dilara Onan, Paolo Martelletti (2024). Onabotulinumtoxin A for the Treatment of Post-Traumatic Headache: Is It Better than Anti-CGRP Antibodies? Toxins. https://doi.org/10.3390/toxins16100427 PMID: 39453203",
                    "39453203"
                ],
                [
                    "Richard B Lipton (2024). Preventive Treatment of Migraine. Continuum (Minneapolis, Minn.), 364-378. https://doi.org/10.1212/CON.0000000000001418 PMID: 38568488",
                    "38568488"
                ],
                [
                    "Katherine Phillips, Benjamin R Wakerley (2024). CGRP therapy in primary care for migraine: prevention and acute medication. The British journal of general practice : the journal of the Royal College of General Practitioners, 521-522. https://doi.org/10.3399/bjgp24X739893 PMID: 39481905",
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                ],
                [
                    "Nazia Karsan, Lars Edvinsson, Laszlo Vecsei, Peter J Goadsby (2024). Pituitary cyclase-activating polypeptide targeted treatments for the treatment of primary headache disorders. Annals of clinical and translational neurology, 1654-1668. https://doi.org/10.1002/acn3.52119 PMID: 38887982",
                    "38887982"
                ]
            ]
        ],
        [
            [
                "Migraine",
                "EDNRA"
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            [
                [
                    "Ewa Kosior-Jarecka, Dominika Wróbel-Dudzińska, Urszula Łukasik, Tin Aung, Chiea Chuen Khor, Janusz Kocki, Tomasz Żarnowski (2016). Plasma endothelin-1 and single nucleotide polymorphisms of endothelin-1 and endothelin type A receptor genes as risk factors for normal tension glaucoma. Molecular vision, 1256-1266. PMID: 27777505",
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                ],
                [
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                ],
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                ],
                [
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                    "19558538"
                ],
                [
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                ],
                [
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                ],
                [
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                    "11376172"
                ]
            ]
        ],
        [
            [
                "Migraine",
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            9.583269999999999,
            [
                [
                    "Neil P Monaghan, Sunny Shah, Brian A Keith, Shaun A Nguyen, Danforth A Newton, John E Baatz, Carol L Wagner, Habib G Rizk (2025). Proinflammatory Cytokine Profiles in Menière's Disease and Vestibular Migraine. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 88-95. https://doi.org/10.1097/MAO.0000000000004372 PMID: 39627868",
                    "39627868"
                ],
                [
                    "Yao Zhang, Fei Ge, Yamin Luo, Xuenian Ji, Zijian Liu, Yuehua Qiu, Jianchen Hou, Ranran Zhou, Caihong Zhao, Qianwei Xu, Shujing Zhang, Xue Yu, Chunguo Wang, Dongyu Ge, Fengxian Meng, Xiaohua Tao (2024). Paeonol and glycyrrhizic acid in combination ameliorate the recurrent nitroglycerin-induced migraine-like phenotype in rats by regulating the GABBR2/TRPM8/PRKACA/TRPV1 pathway. Journal of ethnopharmacology, 118464. https://doi.org/10.1016/j.jep.2024.118464 PMID: 38908492",
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                ],
                [
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                ],
                [
                    "Guangshuang Lu, Shaobo Xiao, Fanchao Meng, Leyi Zhang, Yan Chang, Jinjing Zhao, Nan Gao, Wenjie Su, Xinghao Guo, Yingyuan Liu, Chenhao Li, Wenjing Tang, Liping Zou, Shengyuan Yu, Ruozhuo Liu (2024). AMPK activation attenuates central sensitization in a recurrent nitroglycerin-induced chronic migraine mouse model by promoting microglial M2-type polarization. The journal of headache and pain, 29. https://doi.org/10.1186/s10194-024-01739-w PMID: 38454376",
                    "38454376"
                ],
                [
                    "Yingyuan Liu, Zihua Gong, Deqi Zhai, Chunxiao Yang, Guangshuang Lu, Shuqing Wang, Shaobo Xiao, Chenhao Li, Ludan Chen, Xiaoxue Lin, Shuhua Zhang, Shengyuan Yu, Zhao Dong (2024). Unveiling the therapeutic potential of Dl-3-n-butylphthalide in NTG-induced migraine mouse: activating the Nrf2 pathway to alleviate oxidative stress and neuroinflammation. The journal of headache and pain, 50. https://doi.org/10.1186/s10194-024-01750-1 PMID: 38565987",
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                ],
                [
                    "Nancy Abdel Hamid Abou Youssef, Gihan Salah Labib, Abeer Ahmed Kassem, Nesrine S El-Mezayen (2024). Zolmitriptan niosomal transdermal patches: combating migraine via epigenetic and endocannabinoid pathways and reversal of migraine hypercoagulability. Drug delivery and translational research. https://doi.org/10.1007/s13346-024-01731-6 PMID: 39500819",
                    "39500819"
                ],
                [
                    "Ning An, Yingying Zhang, Jinding Xie, Jingchao Li, Jing Lin, Qiuyan Li, Yating Wang, Yang Liu, Yindong Yang (2024). Study on the involvement of microglial S100A8 in neuroinflammation and microglia activation during migraine attacks. Molecular and cellular neurosciences, 103957. https://doi.org/10.1016/j.mcn.2024.103957 PMID: 39111720",
                    "39111720"
                ],
                [
                    "Johanna Ruhnau, Max Blücher, Susanne Bahlmann, Almut Zieme, Antje Vogelgesang, Anke Steinmetz, Robert Fleischmann (2024). Occurrence of new or more severe headaches following COVID-19 is associated with markers of microglial activation and peripheral sensitization: results from a prospective cohort study. The journal of headache and pain, 101. https://doi.org/10.1186/s10194-024-01810-6 PMID: 38890625",
                    "38890625"
                ],
                [
                    "Tamás Körtési, Gábor Nagy-Grócz, László Vécsei (2024). The role of kynurenines in migraine-related neuroimmune pathways. The journal of headache and pain, 129. https://doi.org/10.1186/s10194-024-01833-z PMID: 39107712",
                    "39107712"
                ],
                [
                    "Amrit Sudershan, Srishty Sudershan, Mohd Younis, Meenakshi Bhagat, Agar Chander Pushap, Hardeep Kumar, Parvinder Kumar (2023). Enlightening the association between TNF-α -308 G > A and migraine: a meta-analysis with meta-regression and trial sequential analysis. BMC neurology, 159. https://doi.org/10.1186/s12883-023-03174-x PMID: 37085790",
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                ],
                [
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}