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                [
                    "Xin Jiang, Ziqing Yuan, Tingbo Ding, Ker Yu, Jibin Dong (2024). SMS2 siRNA inhibits pancreatic tumor growth by tumor microenvironment modulation. International immunopharmacology, 113111. https://doi.org/10.1016/j.intimp.2024.113111 PMID: 39255679",
                    "39255679"
                ],
                [
                    "Tongyang Gong, Wanyuan Sun, Xukun Li, Jiahui Cai, Ning Zhao, Minyi Lu, Juan Xu, Zhihua Liu, Hongyan Chen (2024). TMSB4Y restrains sphingomyelin synthesis via de novo purine synthesis to exert a tumor suppressor function in male esophageal squamous cell carcinoma. Oncogene, 3660-3672. https://doi.org/10.1038/s41388-024-03193-z PMID: 39443723",
                    "39443723"
                ],
                [
                    "Yeun-Po Chiang, Zhiqiang Li, Mulin He, Quiana Jones, Meixia Pan, Xianlin Han, Xian-Cheng Jiang (2023). Sphingomyelin synthase-related protein SMSr is a phosphatidylethanolamine phospholipase C that promotes nonalcoholic fatty liver disease. The Journal of biological chemistry, 105162. https://doi.org/10.1016/j.jbc.2023.105162 PMID: 37586586",
                    "37586586"
                ],
                [
                    "Yan Ruochen, Ji Wenbin, Gao Chao, Yuan Yuhua, Qi Feng (2023). SGMS1-AS1/MicroRNA-106a-5p/CPT2 Axis as a Novel Target for Regulating Lactate Metabolism in Colon Cancer. Technology in cancer research & treatment, 15330338231212071. https://doi.org/10.1177/15330338231212071 PMID: 37926998",
                    "37926998"
                ],
                [
                    "Yonghao Sun, Yingkun Xu, Xiangyu Che, Guangzhen Wu (2022). Development of a Novel Sphingolipid Signaling Pathway-Related Risk Assessment Model to Predict Prognosis in Kidney Renal Clear Cell Carcinoma. Frontiers in cell and developmental biology, 881490. https://doi.org/10.3389/fcell.2022.881490 PMID: 35846357",
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                ],
                [
                    "Camille Malouf, Eric T B Antunes, Michael O'Dwyer, Hélène Jakobczyk, Franziska Sahm, Sophie-Luise Landua, Richard A Anderson, Abdenour Soufi, Christina Halsey, Katrin Ottersbach (2021). miR-130b and miR-128a are essential lineage-specific codrivers of t(4;11) MLL-AF4 acute leukemia. Blood, 2066-2092. https://doi.org/10.1182/blood.2020006610 PMID: 34111240",
                    "34111240"
                ],
                [
                    "Xiao-Li Wei, Tian-Qi Luo, Jia-Ning Li, Zhi-Cheng Xue, Yun Wang, You Zhang, Ying-Bo Chen, Chuan Peng (2021). Development and Validation of a Prognostic Classifier Based on Lipid Metabolism-Related Genes in Gastric Cancer. Frontiers in molecular biosciences, 691143. https://doi.org/10.3389/fmolb.2021.691143 PMID: 34277706",
                    "34277706"
                ],
                [
                    "Fang Jing, Chao Jing, Xiaoyan Dai, Guang Zhou, Shi Di, Xiaoxia Bi, Tingting Dai, Tingting Qin, Li Hong (2021). Sphingomyelin synthase 2 but not sphingomyelin synthase 1 is upregulated in ovarian cancer and involved in migration, growth and survival via different mechanisms. American journal of translational research, 4412-4421. PMID: 34150023",
                    "34150023"
                ],
                [
                    "Priyanka Bhadwal, Divya Dahiya, Dhananjay Shinde, Kim Vaiphei, Raviswamy G H Math, Vinay Randhawa, Navneet Agnihotri (2020). LC-HRMS based approach to identify novel sphingolipid biomarkers in breast cancer patients. Scientific reports, 4668. https://doi.org/10.1038/s41598-020-61283-w PMID: 32170160",
                    "32170160"
                ],
                [
                    "Fatima Bilal, Anne Montfort, Julia Gilhodes, Virginie Garcia, Joëlle Riond, Stéphane Carpentier, Thomas Filleron, Céline Colacios, Thierry Levade, Ahmad Daher, Nicolas Meyer, Nathalie Andrieu-Abadie, Bruno Ségui (2019). Sphingomyelin Synthase 1 (SMS1) Downregulation Is Associated With Sphingolipid Reprogramming and a Worse Prognosis in Melanoma. Frontiers in pharmacology, 443. https://doi.org/10.3389/fphar.2019.00443 PMID: 31114500",
                    "31114500"
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            [
                [
                    "Jing Chen, Morag A Lewis, Alisa Wai, Lucia Yin, Sally J Dawson, Neil J Ingham, Karen P Steel (2024). A new mutation of Sgms1 causes gradual hearing loss associated with a reduced endocochlear potential. Hearing research, 109091. https://doi.org/10.1016/j.heares.2024.109091 PMID: 39067415",
                    "39067415"
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                [
                    "Yamila Romina Brandán, Nicolás Octavio Favale, Lucila Gisele Pescio, Bruno Jaime Santacreu, Edith Del Valle Guaytima, Norma B Sterin-Speziale, María Gabriela Márquez (2022). Influence of sphingomyelin metabolism during epithelial-mesenchymal transition associated with aging in the renal papilla. Journal of cellular physiology, 3883-3899. https://doi.org/10.1002/jcp.30842 PMID: 35908199",
                    "35908199"
                ],
                [
                    "Kamila Prymas, Anna Świątkowska, Gabriela Traczyk, Ewelina Ziemlińska, Anna Dziewulska, Anna Ciesielska, Katarzyna Kwiatkowska (2020). Sphingomyelin synthase activity affects TRIF-dependent signaling of Toll-like receptor 4 in cells stimulated with lipopolysaccharide. Biochimica et biophysica acta. Molecular and cell biology of lipids, 158549. https://doi.org/10.1016/j.bbalip.2019.158549 PMID: 31678513",
                    "31678513"
                ],
                [
                    "Kehong Zheng, Zetao Chen, Haizhan Feng, Ying Chen, Cheng Zhang, Jinlong Yu, Yunfeng Luo, Liang Zhao, Xiancheng Jiang, Fujun Shi (2019). Sphingomyelin synthase 2 promotes an aggressive breast cancer phenotype by disrupting the homoeostasis of ceramide and sphingomyelin. Cell death & disease, 157. https://doi.org/10.1038/s41419-019-1303-0 PMID: 30770781",
                    "30770781"
                ],
                [
                    "Fatima Bilal, Anne Montfort, Julia Gilhodes, Virginie Garcia, Joëlle Riond, Stéphane Carpentier, Thomas Filleron, Céline Colacios, Thierry Levade, Ahmad Daher, Nicolas Meyer, Nathalie Andrieu-Abadie, Bruno Ségui (2019). Sphingomyelin Synthase 1 (SMS1) Downregulation Is Associated With Sphingolipid Reprogramming and a Worse Prognosis in Melanoma. Frontiers in pharmacology, 443. https://doi.org/10.3389/fphar.2019.00443 PMID: 31114500",
                    "31114500"
                ],
                [
                    "Elodie Lafont, Romain Dupont, Nathalie Andrieu-Abadie, Toshiro Okazaki, Klaus Schulze-Osthoff, Thierry Levade, Hervé Benoist, Bruno Ségui (2012). Ordering of ceramide formation and caspase-9 activation in CD95L-induced Jurkat leukemia T cell apoptosis. Biochimica et biophysica acta, 684-93. https://doi.org/10.1016/j.bbalip.2012.01.012 PMID: 22306364",
                    "22306364"
                ],
                [
                    "Ya-Rui Zhao, Ji-Bin Dong, Yue Li, Man-Ping Wu (2012). Sphingomyelin synthase 2 over-expression induces expression of aortic inflammatory biomarkers and decreases circulating EPCs in ApoE KO mice. Life sciences, 867-73. https://doi.org/10.1016/j.lfs.2012.04.003 PMID: 22538014",
                    "22538014"
                ],
                [
                    "Yujiro Kidani, Ken-ichi Ohshima, Hideyuki Sakai, Takao Kohno, Atsushi Baba, Mitsuharu Hattori (2012). Differential localization of sphingomyelin synthase isoforms in neurons regulates sphingomyelin cluster formation. Biochemical and biophysical research communications, 1014-7. https://doi.org/10.1016/j.bbrc.2011.12.079 PMID: 22209789",
                    "22209789"
                ],
                [
                    "E Lafont, D Milhas, S Carpentier, V Garcia, Z-X Jin, H Umehara, T Okazaki, K Schulze-Osthoff, T Levade, H Benoist, B Ségui (2010). Caspase-mediated inhibition of sphingomyelin synthesis is involved in FasL-triggered cell death. Cell death and differentiation, 642-54. https://doi.org/10.1038/cdd.2009.130 PMID: 19779494",
                    "19779494"
                ],
                [
                    "Tinbo Ding, Zhiqiang Li, Tiruneh Hailemariam, Sushmita Mukherjee, Frederick R Maxfield, Man-Ping Wu, Xian-Cheng Jiang (2008). SMS overexpression and knockdown: impact on cellular sphingomyelin and diacylglycerol metabolism, and cell apoptosis. Journal of lipid research, 376-85. https://doi.org/10.1194/jlr.M700401-JLR200 PMID: 17982138",
                    "17982138"
                ]
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                [
                    "Chiaki Murakami, Kamila Dilimulati, Kyoko Atsuta-Tsunoda, Takuma Kawai, Sho Inomata, Yasuhisa Hijikata, Hiromichi Sakai, Fumio Sakane (2024). Multiple activities of sphingomyelin synthase 2 generate saturated fatty acid- and/or monounsaturated fatty acid-containing diacylglycerol. The Journal of biological chemistry, 107960. https://doi.org/10.1016/j.jbc.2024.107960 PMID: 39510177",
                    "39510177"
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                [
                    "Yamila Romina Brandán, Nicolás Octavio Favale, Lucila Gisele Pescio, Bruno Jaime Santacreu, Edith Del Valle Guaytima, Norma B Sterin-Speziale, María Gabriela Márquez (2022). Influence of sphingomyelin metabolism during epithelial-mesenchymal transition associated with aging in the renal papilla. Journal of cellular physiology, 3883-3899. https://doi.org/10.1002/jcp.30842 PMID: 35908199",
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                [
                    "Ting Wang, Jingmin Zhang, Meng Yang, Jinxiu Guo, Duolu Li, Ying Li (2022). Lipidomics Analysis Reveals a Protective Effect of Myriocin on Cerebral Ischemia/Reperfusion Model Rats. Journal of molecular neuroscience : MN, 1846-1858. https://doi.org/10.1007/s12031-022-02014-w PMID: 35776315",
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                [
                    "Xiao-Li Wei, Tian-Qi Luo, Jia-Ning Li, Zhi-Cheng Xue, Yun Wang, You Zhang, Ying-Bo Chen, Chuan Peng (2021). Development and Validation of a Prognostic Classifier Based on Lipid Metabolism-Related Genes in Gastric Cancer. Frontiers in molecular biosciences, 691143. https://doi.org/10.3389/fmolb.2021.691143 PMID: 34277706",
                    "34277706"
                ],
                [
                    "Yeun-Po Chiang, Zhiqiang Li, Yang Chen, Yu Cao, Xian-Cheng Jiang (2021). Sphingomyelin synthases 1 and 2 exhibit phosphatidylcholine phospholipase C activity. The Journal of biological chemistry, 101398. https://doi.org/10.1016/j.jbc.2021.101398 PMID: 34774525",
                    "34774525"
                ],
                [
                    "Priyanka Bhadwal, Divya Dahiya, Dhananjay Shinde, Kim Vaiphei, Raviswamy G H Math, Vinay Randhawa, Navneet Agnihotri (2020). LC-HRMS based approach to identify novel sphingolipid biomarkers in breast cancer patients. Scientific reports, 4668. https://doi.org/10.1038/s41598-020-61283-w PMID: 32170160",
                    "32170160"
                ],
                [
                    "Gayatri Gupta, Nathalie Baumlin, Justin Poon, Begum Ahmed, Yeun-Po Chiang, Christopher Railwah, Michael D Kim, Melissa Rivas, Hannah Goldenberg, Ziyad Elgamal, Matthias Salathe, Apurav A Panwala, Abdoulaye Dabo, Chongmin Huan, Robert Foronjy, Xian-Cheng Jiang, Raj Wadgaonkar, Patrick Geraghty (2020). Airway Resistance Caused by Sphingomyelin Synthase 2 Insufficiency in Response to Cigarette Smoke. American journal of respiratory cell and molecular biology, 342-353. https://doi.org/10.1165/rcmb.2019-0133OC PMID: 31517509",
                    "31517509"
                ],
                [
                    "Yutong Huang, Taoming Huang, Xiaonuo Zhen, Yali Li, Mingguang Mo, Deyong Ye, Nengneng Cheng (2019). A selective sphingomyelin synthase 2 inhibitor ameliorates diet induced insulin resistance via the IRS-1/Akt/GSK-3β signaling pathway. Die Pharmazie, 553-558. https://doi.org/10.1691/ph.2019.9310 PMID: 31484596",
                    "31484596"
                ],
                [
                    "Mitsuharu Sato, Masanori Arita, Takeshi Kawashima (2019). Uncovering Ecdysozoa-specific Sphingomyelin Synthase by Phylogenetic Analysis of Metazoan Sequences. Zoological science, 316-321. https://doi.org/10.2108/zs180168 PMID: 34664902",
                    "34664902"
                ],
                [
                    "Shuang Liu, Huan Hou, Panpan Zhang, Yifan Wu, Xuanhong He, Hua Li, Nianlong Yan (2019). Sphingomyelin synthase 1 regulates the epithelial‑to‑mesenchymal transition mediated by the TGF‑β/Smad pathway in MDA‑MB‑231 cells. Molecular medicine reports, 1159-1167. https://doi.org/10.3892/mmr.2018.9722 PMID: 30535436",
                    "30535436"
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                [
                    "Giuseppe Pepe, Maria Cotugno, Federico Marracino, Luca Capocci, Ludovica Pizzati, Maurizio Forte, Rosita Stanzione, Pamela Scarselli, Alba Di Pardo, Sebastiano Sciarretta, Massimo Volpe, Speranza Rubattu, Vittorio Maglione (2024). Abnormal expression of sphingolipid-metabolizing enzymes in the heart of spontaneously hypertensive rat models. Biochimica et biophysica acta. Molecular and cell biology of lipids, 159411. https://doi.org/10.1016/j.bbalip.2023.159411 PMID: 37949293",
                    "37949293"
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                [
                    "Chiaki Murakami, Kamila Dilimulati, Kyoko Atsuta-Tsunoda, Takuma Kawai, Sho Inomata, Yasuhisa Hijikata, Hiromichi Sakai, Fumio Sakane (2024). Multiple activities of sphingomyelin synthase 2 generate saturated fatty acid- and/or monounsaturated fatty acid-containing diacylglycerol. The Journal of biological chemistry, 107960. https://doi.org/10.1016/j.jbc.2024.107960 PMID: 39510177",
                    "39510177"
                ],
                [
                    "Xu Congcong, Ye Yuanyuan, Li Caixia, Shang Yazhen (2023). The Effects and Mechanism of Scutellaria baicalensis Georgi Stems and Leaves Flavonoids on Myelin Sheath Degeneration Induced by Composited Aβ in Rats. CNS & neurological disorders drug targets. https://doi.org/10.2174/1871527322666230510103540 PMID: 37218194",
                    "37218194"
                ],
                [
                    "Sandeep Saini, Savi Khurana, Dikshant Saini, Saru Rajput, Chander Jyoti Thakur, Jeevisha Singh, Akanksha Jaswal, Yogesh Kapoor, Varinder Kumar, Avneet Saini (2023). In silico analysis of genomic landscape of SARS-CoV-2 and its variant of concerns (Delta and Omicron) reveals changes in the coding potential of miRNAs and their target genes. Gene, 147097. https://doi.org/10.1016/j.gene.2022.147097 PMID: 36470485",
                    "36470485"
                ],
                [
                    "P Davoodi, A Ehsani, R Vaez Torshizi, A A Masoudi (2022). New insights into genetics underlying of plumage color. Animal genetics, 80-93. https://doi.org/10.1111/age.13156 PMID: 34855995",
                    "34855995"
                ],
                [
                    "Yi-Yu Qi, Xia Heng, Zeng-Ying Yao, Shu-Yue Qu, Ping-Yuan Ge, Xin Zhao, Sai-Jia Ni, Rui Guo, Nian-Yun Yang, Qi-Chun Zhang, Hua-Xu Zhu (2022). Involvement of Huanglian Jiedu Decoction on Microglia with Abnormal Sphingolipid Metabolism in Alzheimer's Disease. Drug design, development and therapy, 931-950. https://doi.org/10.2147/DDDT.S357061 PMID: 35391788",
                    "35391788"
                ],
                [
                    "Ting Wang, Jingmin Zhang, Meng Yang, Jinxiu Guo, Duolu Li, Ying Li (2022). Lipidomics Analysis Reveals a Protective Effect of Myriocin on Cerebral Ischemia/Reperfusion Model Rats. Journal of molecular neuroscience : MN, 1846-1858. https://doi.org/10.1007/s12031-022-02014-w PMID: 35776315",
                    "35776315"
                ],
                [
                    "Yifan Guo, Lin Chang, Ge Zhang, Zhanyan Gao, Hao Lin, Yuting Zhang, Liang Hu, She Chen, Bing Fan, Si Zhang, Ruyi Xue (2021). The role of Sphingomyelin synthase 2 (SMS2) in platelet activation and its clinical significance. Thrombosis journal, 27. https://doi.org/10.1186/s12959-021-00282-x PMID: 33910580",
                    "33910580"
                ],
                [
                    "Chenqiong Wang, Bingxia Ming, Xuefen Wu, Tong Wu, Shaozhe Cai, Peng Hu, Jungen Tang, Zheng Tan, Chaohong Liu, Jixin Zhong, Fang Zheng, Lingli Dong (2019). Sphingomyelin synthase 1 enhances BCR signaling to promote lupus-like autoimmune response. EBioMedicine, 578-587. https://doi.org/10.1016/j.ebiom.2019.06.038 PMID: 31262710",
                    "31262710"
                ],
                [
                    "Yutong Huang, Taoming Huang, Xiaonuo Zhen, Yali Li, Mingguang Mo, Deyong Ye, Nengneng Cheng (2019). A selective sphingomyelin synthase 2 inhibitor ameliorates diet induced insulin resistance via the IRS-1/Akt/GSK-3β signaling pathway. Die Pharmazie, 553-558. https://doi.org/10.1691/ph.2019.9310 PMID: 31484596",
                    "31484596"
                ]
            ]
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        [
            [
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            [
                [
                    "Megumi Kikuchi, Satoru Monzen, Mai Horikoshi, Shuri Tsuda, Yota Tatara, Andrzej Wojcik, Yasushi Mariya (2024). Characteristics of sphingomyelin metabolism in the MCF7 and BT474 radiotherapy‑resistant HER2‑positive breast cancer cell lines. Oncology letters, 471. https://doi.org/10.3892/ol.2024.14604 PMID: 39139746",
                    "39139746"
                ],
                [
                    "Kai Yang, Ying-Yi Luan, Shan Wang, You-Sheng Yan, Yi-Peng Wang, Jue Wu, Yong-Qing Sun, Jing Zhang, Wen-Qi Chen, Yu-Lan Xiang, Ze-Lu Li, Dong-Liang Zhang, Cheng-Hong Yin (2024). SGMS1 facilitates osteogenic differentiation of MSCs and strengthens osteogenesis-angiogenesis coupling by modulating Cer/PP2A/Akt pathway. iScience, 109358. https://doi.org/10.1016/j.isci.2024.109358 PMID: 38544565",
                    "38544565"
                ],
                [
                    "Jue Wang, Shiva Keshava, Kaushik Das, Richard Kolesnick, Xian-Cheng Jiang, Usha R Pendurthi, L Vijaya Mohan Rao (2023). Alterations to Sphingomyelin Metabolism Affect Hemostasis and Thrombosis. Arteriosclerosis, thrombosis, and vascular biology, 64-78. https://doi.org/10.1161/ATVBAHA.122.318443 PMID: 36412194",
                    "36412194"
                ],
                [
                    "Yan Ruochen, Ji Wenbin, Gao Chao, Yuan Yuhua, Qi Feng (2023). SGMS1-AS1/MicroRNA-106a-5p/CPT2 Axis as a Novel Target for Regulating Lactate Metabolism in Colon Cancer. Technology in cancer research & treatment, 15330338231212071. https://doi.org/10.1177/15330338231212071 PMID: 37926998",
                    "37926998"
                ],
                [
                    "Xu Congcong, Ye Yuanyuan, Li Caixia, Shang Yazhen (2023). The Effects and Mechanism of Scutellaria baicalensis Georgi Stems and Leaves Flavonoids on Myelin Sheath Degeneration Induced by Composited Aβ in Rats. CNS & neurological disorders drug targets. https://doi.org/10.2174/1871527322666230510103540 PMID: 37218194",
                    "37218194"
                ],
                [
                    "Florencia X Santiago Valtierra, Marta I Aveldaño, Gerardo M Oresti (2023). Differentiation-linked changes in the biosynthesis and turnover of sphingomyelins in rat male germ cells: Genes involved and effects of testosterone. The Journal of biological chemistry, 103058. https://doi.org/10.1016/j.jbc.2023.103058 PMID: 36841478",
                    "36841478"
                ],
                [
                    "Haonan Yu, Yaorong Niu, Xinyu Lei, Chunlin Xie, Xianghua Yan (2023). Multi-Omics Analysis Reveals Sphingomyelin Accumulation, Glycerolipids Loss, and Disorders of Lipid Metabolism Regulated by Leucine Deprivation in the Liver of Mice. Molecular nutrition & food research, e2300567. https://doi.org/10.1002/mnfr.202300567 PMID: 38059795",
                    "38059795"
                ],
                [
                    "Yi-Yu Qi, Xia Heng, Zeng-Ying Yao, Shu-Yue Qu, Ping-Yuan Ge, Xin Zhao, Sai-Jia Ni, Rui Guo, Nian-Yun Yang, Qi-Chun Zhang, Hua-Xu Zhu (2022). Involvement of Huanglian Jiedu Decoction on Microglia with Abnormal Sphingolipid Metabolism in Alzheimer's Disease. Drug design, development and therapy, 931-950. https://doi.org/10.2147/DDDT.S357061 PMID: 35391788",
                    "35391788"
                ],
                [
                    "Sanghoo Lee, Seol-A Kim, Yejin Kim, Juhoon Kim, Gayeon Hong, Jeonghoon Hong, Kyeonghwan Choi, Chun-Sick Eom, Saeyun Baik, Mi-Kyeong Lee, Kyoung-Ryul Lee (2022). Genetic Variants Associated with Elevated Plasma Ceramides in Individuals with Metabolic Syndrome. Genes. https://doi.org/10.3390/genes13081497 PMID: 36011408",
                    "36011408"
                ],
                [
                    "Makoto Taniguchi, Shingo Nagaya, Kohei Yuyama, Ai Kotani, Yasuyuki Igarashi, Toshiro Okazaki (2022). Ceramide Metabolism Regulated by Sphingomyelin Synthase 2 Is Associated with Acquisition of Chemoresistance via Exosomes in Human Leukemia Cells. International journal of molecular sciences. https://doi.org/10.3390/ijms231810648 PMID: 36142562",
                    "36142562"
                ]
            ]
        ],
        [
            [
                "SMS1",
                "IPSS-R Risk Category Low"
            ],
            0.42288433,
            [
                [
                    "Zakarya Bentatou, Thomas Troalen, Monique Bernard, Maxime Guye, Lauriane Pini, Axel Bartoli, Alexis Jacquier, Frank Kober, Stanislas Rapacchi (2023). Simultaneous multi-slice T1 mapping using MOLLI with blipped CAIPIRINHA bSSFP. Magnetic resonance imaging, 90-102. https://doi.org/10.1016/j.mri.2020.03.006 PMID: 32304799",
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                ],
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                ],
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                ],
                [
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                    "30561621"
                ],
                [
                    "Fatima Bilal, Anne Montfort, Julia Gilhodes, Virginie Garcia, Joëlle Riond, Stéphane Carpentier, Thomas Filleron, Céline Colacios, Thierry Levade, Ahmad Daher, Nicolas Meyer, Nathalie Andrieu-Abadie, Bruno Ségui (2019). Sphingomyelin Synthase 1 (SMS1) Downregulation Is Associated With Sphingolipid Reprogramming and a Worse Prognosis in Melanoma. Frontiers in pharmacology, 443. https://doi.org/10.3389/fphar.2019.00443 PMID: 31114500",
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                ],
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            ]
        ]
    ]
}