{
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            [
                [
                    "Thomas Rosseel, Wouter L'Hoyes, Martijn Rogiers, Peter Haemers, Christophe Garweg, Rik Willems, Joris Ector, Tomas Robyns, Bert Vandenberk (2024). Ajmaline infusion for unmasking short-coupled Purkinje ectopy: Need for speed? Heart rhythm. https://doi.org/10.1016/j.hrthm.2024.08.056 PMID: 39216716",
                    "39216716"
                ],
                [
                    "Miguel Fogaça-da-Mata, Estefanía Martínez-Barrios, Lorenzo Jiménez-Montañés, José Cruzalegui, Fredy Chipa-Ccasani, Andrea Greco, Sergi Cesar, Núria Díez-Escuté, Patricia Cerralbo, Irene Zschaeck, Marcos Clavero Adell, Ariadna Ayerza-Casas, Daniel Palanca-Arias, Marta López, Oscar Campuzano, Josep Brugada, Georgia Sarquella-Brugada (2024). Brugada Syndrome and Pulmonary Atresia with Intact Interventricular Septum: Fortuitous Finding or New Genetic Connection? Genes. https://doi.org/10.3390/genes15050638 PMID: 38790267",
                    "38790267"
                ],
                [
                    "Avi Sabbag, Gisella Amoroso, Orr Tomer, Giulio Conte, Roy Beinart, Eyal Nof, Tardu Özkartal, Pierre Ollitrault, Mikael Laredo, Oholi Tovia-Brodie, Estelle Gandjbakhch, Michele de Benedictis, Rachel M A Ter Bekke, Anat Milman (2024). Clinical differences between drug-induced type 1 Brugada pattern and syndrome. Journal of arrhythmia, 982-990. https://doi.org/10.1002/joa3.13053 PMID: 39139869",
                    "39139869"
                ],
                [
                    "Saverio Iacopino, Emmanuel Fabiano, Paolo Sorrenti, Andrea Petretta, Jacopo Colella, Alessandro Di Vilio, Giovanni Statuto, Pasquale Filannino, Paolo Artale, Daniele Giacopelli, Gianluca Peluso, Gennaro Fabiano, Giuseppe Campagna, Federico Cecchini (2024). Predicting ventricular arrhythmia inducibility in ajmaline-induced Brugada type I pattern: Validation of the dST-Tiso interval. Journal of cardiovascular electrophysiology, 1747-1753. https://doi.org/10.1111/jce.16348 PMID: 38923783",
                    "38923783"
                ],
                [
                    "Sara Latrofa, Valentina Hartwig, Lorenzo Bachi, Pasquale Notarstefano, Silvia Garibaldi, Luca Panchetti, Martina Nesti, Paolo Seghetti, Umberto Startari, Gianluca Mirizzi, Maria Sole Morelli, Martina Modena, Andrea Mazzanti, Michele Emdin, Alberto Giannoni, Andrea Rossi (2024). Endocardial repolarization dispersion in BrS: A novel automatic algorithm for mapping activation recovery interval. Journal of cardiovascular electrophysiology, 965-974. https://doi.org/10.1111/jce.16244 PMID: 38477371",
                    "38477371"
                ],
                [
                    "Paul-Adrian Călburean, Luigi Pannone, Cinzia Monaco, Domenico Della Rocca, Antonio Sorgente, Alexandre Almorad, Gezim Bala, Filippo Aglietti, Robbert Ramak, Ingrid Overeinder, Erwin Ströker, Gudrun Pappaert, Marius Măru'teri, Marius Harpa, Mark La Meir, Pedro Brugada, Juan Sieira, Andrea Sarkozy, Gian-Battista Chierchia, Carlo de Asmundis (2024). Predicting and Recognizing Drug-Induced Type I Brugada Pattern Using ECG-Based Deep Learning. Journal of the American Heart Association, e033148. https://doi.org/10.1161/JAHA.123.033148 PMID: 38726893",
                    "38726893"
                ],
                [
                    "Eraldo Occhetta, Federica De Vecchi, Lorella Barbonaglia, Chiara Devecchi, Mario Matta, Maurizio Malacrida, Giuseppe Patti, Francesco Rametta (2023). Can specific ECG markers identify a pharmacologically induced type 1 Brugada pattern? Insights from a large, single-center cohort. Journal of electrocardiology, 123-131. https://doi.org/10.1016/j.jelectrocard.2023.08.017 PMID: 37688842",
                    "37688842"
                ],
                [
                    "Angelo Auricchio, Andrea Demarchi, Tardu Özkartal, Daniela Campanale, Maria Luce Caputo, Marcello di Valentino, Andrea Menafoglio, Francois Regoli, Marco Facchini, Alessandro Del Bufalo, Pietro Foglia, Nicola Ferrari, Fulvio Bomio, Argelia Medeiros-Domingo, Tiziano Moccetti, Giovanni B Pedrazzini, Catherine Klersy, Giulio Conte (2023). Role of genetic testing in young patients with idiopathic atrioventricular conduction disease. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 643-650. https://doi.org/10.1093/europace/euac196 PMID: 36352534",
                    "36352534"
                ],
                [
                    "Antonio Bisignani, Luigi Pannone, Alvise Del Monte, Ivan Eltsov, Ida Anna Cappello, Juan Sieira, Cinzia Monaco, Gezim Bala, Sahar Mouram, Domenico Giovanni Della Rocca, Erwin Ströker, Ingrid Overeinder, Alexandre Almorad, Gudrun Pappaert, Anaïs Gauthey, Thomy de Ravel, Sonia Van Dooren, Antonio Sorgente, Mark La Meir, Andrea Sarkozy, Pedro Brugada, Gian-Battista Chierchia, Carlo de Asmundis (2023). Atrial Abnormalities in Brugada Syndrome: Evaluation With ECG Imaging. JACC. Clinical electrophysiology, 2096-2105. https://doi.org/10.1016/j.jacep.2023.06.011 PMID: 37565952",
                    "37565952"
                ],
                [
                    "Hans Ebbinghaus, Laura Ueberham, Daniela Husser-Bollmann, Andreas Bollmann, Ulrich Laufs, Borislav Dinov (2023). Case Report: Four cases of cardiac sarcoidosis in patients with inherited cardiomyopathy-a phenotypic overlap, co-existence of two rare cardiomyopathies or a second-hit disease. Frontiers in cardiovascular medicine, 1328802. https://doi.org/10.3389/fcvm.2023.1328802 PMID: 38173816",
                    "38173816"
                ]
            ]
        ],
        [
            [
                "SCN10A",
                "Lidocaine"
            ],
            15.260357,
            [
                [
                    "Felix J Resch, Stefan Heber, Farzin Shahi, Manuel Zauner, Cosmin I Ciotu, Andreas Gleiss, Sabine Sator, Michael J M Fischer (2024). Human cold pain: a randomized crossover trial. Pain. https://doi.org/10.1097/j.pain.0000000000003503 PMID: 39693244",
                    "39693244"
                ],
                [
                    "Ertuğrul Karataş, Meltem Sümbüllü, Çiğdem Y Kahraman, Fatma A Çakmak (2023). Association Between Single-nucleotide Polymorphisms in Candidate Genes and Success of Pulpal Anesthesia after Inferior Alveolar Nerve Block. Journal of endodontics, 18-25. https://doi.org/10.1016/j.joen.2022.09.004 PMID: 37185254",
                    "37185254"
                ],
                [
                    "Reham Alfaraj, Zainab Alabdulsalam, Zahrah Alfaraj, Hawraa Alsunni, Hussain Alhawaj, Omar Omar, Hatem Abuohashish (2022). Caffeine Consumption Influences Lidocaine Action via Pain-Related Voltage-Gated Sodium Channels: An In Vivo Animal Study. Pain research & management, 6107292. https://doi.org/10.1155/2022/6107292 PMID: 35027984",
                    "35027984"
                ],
                [
                    "Kuang-Yi Tseng, Hung-Chen Wang, Lin-Li Chang, Kuang-I Cheng (2018). Advances in Experimental Medicine and Biology: Intrafascicular Local Anesthetic Injection Damages Peripheral Nerve-Induced Neuropathic Pain. Advances in experimental medicine and biology, 65-76. https://doi.org/10.1007/978-981-13-1756-9_6 PMID: 30306515",
                    "30306515"
                ],
                [
                    "Luisa Kaluza, Jannis E Meents, Martin Hampl, Corinna Rösseler, Petra A I Hautvast, Silvia Detro-Dassen, Ralf Hausmann, Günther Schmalzing, Angelika Lampert (2018). Loss-of-function of Nav1.8/D1639N linked to human pain can be rescued by lidocaine. Pflugers Archiv : European journal of physiology, 1787-1801. https://doi.org/10.1007/s00424-018-2189-x PMID: 30099632",
                    "30099632"
                ],
                [
                    "Filip Touska, Simon Sattler, Philipp Malsch, Richard J Lewis, Peter W Reeh, Katharina Zimmermann (2017). Ciguatoxins Evoke Potent CGRP Release by Activation of Voltage-Gated Sodium Channel Subtypes NaV1.9, NaV1.7 and NaV1.1. Marine drugs. https://doi.org/10.3390/md15090269 PMID: 28867800",
                    "28867800"
                ],
                [
                    "Kuang-I Cheng, Hung-Chen Wang, Yi-Chia Wu, Kuang-Yi Tseng, Yi-Ta Chuang, Chao-Wen Chou, Ping-Luen Chen, Lin-Li Chang, Chung-Sheng Lai (2016). Sciatic Nerve Intrafascicular Lidocaine Injection-induced Peripheral Neuropathic Pain: Alleviation by Systemic Minocycline Administration. The Clinical journal of pain, 513-21. https://doi.org/10.1097/AJP.0000000000000293 PMID: 26340654",
                    "26340654"
                ],
                [
                    "Tomas Koltai (2015). Voltage-gated sodium channel as a target for metastatic risk reduction with re-purposed drugs. F1000Research, 297. https://doi.org/10.12688/f1000research.6789.1 PMID: 27408684",
                    "27408684"
                ],
                [
                    "Zhonglin Han, Yu Jiang, Feng Xiao, Kejiang Cao, Dao W Wang (2015). The effects of A-803467 on cardiac Nav1.5 channels. European journal of pharmacology, 52-60. PMID: 25701724",
                    "25701724"
                ],
                [
                    "Xiaojia Wang, Cheng Zhou, Peng Liang, Jun Yang, Fengshan Li, Daqing Liao, Han Huang, Jin Liu (2015). Characterization of Specific Roles of Sodium Channel Subtypes in Regional Anesthesia. Regional anesthesia and pain medicine, 599-604. https://doi.org/10.1097/AAP.0000000000000294 PMID: 26236999",
                    "26236999"
                ]
            ]
        ],
        [
            [
                "SCN5A",
                "Ranolazine"
            ],
            10.20968,
            [
                [
                    "Hui Yang, Mengqin Jing, Chao Tian, Bingxun Li, Weiming Liao, Wei Wang, Yunzhe Li, Xiaowei Wang, Guifang Duan, Qi Sun, Zhuo Huang, Lin Wu (2024). 1,4-Disubstituted Piperazin-2-Ones as Selective Late Sodium Current Inhibitors with QT Interval Shortening Properties in Isolated Rabbit Hearts. Journal of medicinal chemistry, 12676-12694. https://doi.org/10.1021/acs.jmedchem.4c00677 PMID: 38757601",
                    "38757601"
                ],
                [
                    "Michael Lenaeus, Tamer M Gamal El-Din, Lige Tonggu, Ning Zheng, William A Catterall (2023). Structural basis for inhibition of the cardiac sodium channel by the atypical antiarrhythmic drug ranolazine. Nature cardiovascular research, 587-594. https://doi.org/10.1038/s44161-023-00271-5 PMID: 39185478",
                    "39185478"
                ],
                [
                    "Tae Hee Ko, Daun Jeong, Byeongil Yu, Ji Eun Song, Qui Anh Le, Sun-Hee Woo, Jong-Il Choi (2023). Inhibition of late sodium current via PI3K/Akt signaling prevents cellular remodeling in tachypacing-induced HL-1 atrial myocytes. Pflugers Archiv : European journal of physiology, 217-231. https://doi.org/10.1007/s00424-022-02754-z PMID: 36274100",
                    "36274100"
                ],
                [
                    "Shubham Banga, Manish Mishra, Stefan D Heinze-Milne, Hailey J Jansen, Robert A Rose, Susan E Howlett (2023). Chronic testosterone deficiency increases late inward sodium current and promotes triggered activity in ventricular myocytes from aging male mice. American journal of physiology. Heart and circulatory physiology, H264-H277. https://doi.org/10.1152/ajpheart.00505.2022 PMID: 37389950",
                    "37389950"
                ],
                [
                    "Paloma Nieto-Marín, David Tinaquero, Raquel G Utrilla, Jorge Cebrián, Andrés González-Guerra, Teresa Crespo-García, Anabel Cámara-Checa, Marcos Rubio-Alarcón, María Dago, Silvia Alfayate, David Filgueiras-Rama, Rafael Peinado, José Luis López-Sendón, José Jalife, Juan Tamargo, Juan Antonio Bernal, Ricardo Caballero, Eva Delpón,   (2022). Tbx5 variants disrupt Nav1.5 function differently in patients diagnosed with Brugada or Long QT Syndrome. Cardiovascular research, 1046-1060. https://doi.org/10.1093/cvr/cvab045 PMID: 33576403",
                    "33576403"
                ],
                [
                    "Koenraad Philippaert, Subha Kalyaanamoorthy, Mohammad Fatehi, Wentong Long, Shubham Soni, Nikole J Byrne, Amy Barr, Jyoti Singh, Jordan Wong, Taylor Palechuk, Chloe Schneider, Ahmed M Darwesh, Zaid H Maayah, John M Seubert, Khaled Barakat, Jason R B Dyck, Peter E Light (2021). Cardiac Late Sodium Channel Current Is a Molecular Target for the Sodium/Glucose Cotransporter 2 Inhibitor Empagliflozin. Circulation, 2188-2204. https://doi.org/10.1161/CIRCULATIONAHA.121.053350 PMID: 33832341",
                    "33832341"
                ],
                [
                    "Ying Yang, Ting-Ting Lv, Si-Yuan Li, Ping Zhang (2021). Sodium channel blockers in the management of long QT syndrome types 3 and 2: A system review and meta-analysis. Journal of cardiovascular electrophysiology, 3057-3067. https://doi.org/10.1111/jce.15223 PMID: 34427958",
                    "34427958"
                ],
                [
                    "Iacopo Galleano, Hendrik Harms, Koushik Choudhury, Keith Khoo, Lucie Delemotte, Stephan Alexander Pless (2021). Functional cross-talk between phosphorylation and disease-causing mutations in the cardiac sodium channel Nav1.5. Proceedings of the National Academy of Sciences of the United States of America. https://doi.org/10.1073/pnas.2025320118 PMID: 34373326",
                    "34373326"
                ],
                [
                    "Jordi Cano, Esther Zorio, Andrea Mazzanti, Miguel Ángel Arnau, Beatriz Trenor, Silvia G Priori, Javier Saiz, Lucia Romero (2020). Ranolazine as an Alternative Therapy to Flecainide for SCN5A V411M Long QT Syndrome Type 3 Patients. Frontiers in pharmacology, 580481. https://doi.org/10.3389/fphar.2020.580481 PMID: 33519442",
                    "33519442"
                ],
                [
                    "Ming-Chi Lai, Sheng-Nan Wu, Chin-Wei Huang (2020). Telmisartan, an Antagonist of Angiotensin II Receptors, Accentuates Voltage-Gated Na+ Currents and Hippocampal Neuronal Excitability. Frontiers in neuroscience, 902. https://doi.org/10.3389/fnins.2020.00902 PMID: 33013297",
                    "33013297"
                ]
            ]
        ],
        [
            [
                "Brugada Syndrome",
                "ICD"
            ],
            14.056824,
            [
                [
                    "Hei-To Leung, Sit-Yee Kwok, Fong-Ying Shih, Kin-Shing Lun, Tak-Cheung Yung, Sabrina Tsao (2025). A Tale of Two Conditions: Pediatric Brugada Syndrome Unveiled-Navigating the Challenges of Coexisting Arrhythmia and Fever-Induced ECG Pattern. Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc, e70009. https://doi.org/10.1111/anec.70009 PMID: 39726150",
                    "39726150"
                ],
                [
                    "Jack Jnani, Dorota Gruber, Tafadzwa Mtisi, Moussa Saleh, Bani M Azari (2024). Identification of a SCN5A Genetic Variant Associated With Type 1 Brugada Syndrome (BrS) in a Family. Cureus, e64883. https://doi.org/10.7759/cureus.64883 PMID: 39156269",
                    "39156269"
                ],
                [
                    "Leonie Verkerk, Arie O Verkerk, Ronald Wilders (2024). Zebrafish as a Model System for Brugada Syndrome. Reviews in cardiovascular medicine, 313. https://doi.org/10.31083/j.rcm2509313 PMID: 39355588",
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                ],
                [
                    "Majid Haghjoo, Amir Askarinejad, Shabnam Madadi, Amirfarjam Fazelifar, Farzad Kamali, Abolfath Alizadeh-Diz, Zahra Emkanjoo (2024). Brugada syndrome in Iran: Insights from a 12-year longitudinal study. Journal of cardiovascular electrophysiology, 708-714. https://doi.org/10.1111/jce.16206 PMID: 38348526",
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                ],
                [
                    "Katharina Koepsel, Tobias C Dreher, Christian Blockhaus, Michael Gotzmann, Norbert Klein, Thomas Kuntz, Dong-In Shin, Hendrik Lapp, Fabian Schiedat, Mohammad Abumayyaleh, Thomas Beiert, Christian Weth, Boldizsar Kovacs, Stephanie Rosenkaimer, Jacqueline Kowitz, Ardan Muammer Saguner, Julia W Erath, Firat Duru, Andreas Mügge, Ibrahim Akin, Assem Aweimer, Nazha Hamdani, Ibrahim El-Battrawy (2024). No beneficial use of the wearable cardioverter defibrillator among patients suffering from inherited and congenital heart disease: data from a European multicenter registry. Frontiers in cardiovascular medicine, 1384736. https://doi.org/10.3389/fcvm.2024.1384736 PMID: 39049954",
                    "39049954"
                ],
                [
                    "Athanasios Saplaouras, Ourania Kariki, Panagiotis Mililis, Andromahi Zygouri, Aggeliki Gkouziouta, George Poulos, Stamatis Adamopoulos, Michael Efremidis, Evangelia Nyktari, Konstantinos P Letsas (2023). Diagnostic and therapeutic dilemmas in a patient with myocarditis, Brugada syndrome and arrhythmic syncope. Journal of electrocardiology, 45-50. https://doi.org/10.1016/j.jelectrocard.2023.04.006 PMID: 37187131",
                    "37187131"
                ],
                [
                    "Zahid Khan (2023). A Case of Young Brugada Syndrome Patient With Implantable Cardioverter Defibrillator Complication Requiring Device Extraction and Reimplantation. Cureus, e43576. https://doi.org/10.7759/cureus.43576 PMID: 37719594",
                    "37719594"
                ],
                [
                    "Vincenzo Russo, Alfredo Caturano, Federico Guerra, Federico Migliore, Giuseppe Mascia, Andrea Rossi, Martina Nesti, Vincenzo Ezio Santobuono, Emilio Attena, Gianfranco Tola, Luigi Sciarra, Giulio Conte, Alessandro Paoletti Perini, Pietro Francia, Gregory Dendramis, Zefferino Palamà, Stefano Albani, Andrea Ottonelli Ghidini, Leonardo Calò, Antonio D'Onofrio, Enrico Baldi,   (2023). Subcutaneous versus transvenous implantable cardioverter-defibrillator among drug-induced type-1 ECG pattern Brugada syndrome: a propensity score matching analysis from IBRYD study. Heart and vessels, 680-688. https://doi.org/10.1007/s00380-022-02204-x PMID: 36418560",
                    "36418560"
                ],
                [
                    "Maria d'Apolito, Francesco Santoro, Rosa Santacroce, Giorgia Cordisco, Ilaria Ragnatela, Girolamo D'Arienzo, Pier Luigi Pellegrino, Natale Daniele Brunetti, Maurizio Margaglione (2023). A Novel DLG1 Variant in a Family with Brugada Syndrome: Clinical Characteristics and In Silico Analysis. Genes. https://doi.org/10.3390/genes14020427 PMID: 36833354",
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                ],
                [
                    "Ivan Eltsov, Cinzia Monaco, Gian-Battista Chierchia, Mark La Meir, Carlo de Asmundis (2022). Hybrid Surgical Ablation of Recurrent Ventricular Tachycardia in a Patient With High-Risk Brugada Syndrome. JACC. Case reports, 214-220. https://doi.org/10.1016/j.jaccas.2021.11.018 PMID: 35199019",
                    "35199019"
                ]
            ]
        ],
        [
            [
                "Brugada Syndrome",
                "SCN10A"
            ],
            10.310587,
            [
                [
                    "Lu-Chen Weng, Shaan Khurshid, Amelia Weber Hall, Victor Nauffal, Valerie N Morrill, Yan V Sun, Joel T Rämö, Dominik Beer, Simon Lee, Girish Nadkarni, Renee Johnson, Laura Andreasen, Anne Clayton, Clive R Pullinger, Zachary T Yoneda, Daniel J Friedman, Matthew C Hyman, Renae L Judy, Allan C Skanes, Kate M Orland, Paloma Jordà, Timothy M Treu, Matthew T Oetjens, Rajesh Subbiah, Jacob P Hartmann, Heidi T May, John P Kane, Tariq Z Issa, Navid A Nafissi, Peter Leong-Sit, Marie-Pierre Dubé, Carolina Roselli, Seung Hoan Choi,  , Jean-Claude Tardif, Habib R Khan, Stacey Knight, Jesper H Svendsen, Bruce Walker, Richard Karlsson Linnér, J Michael Gaziano, Rafik Tadros, Diane Fatkin, Daniel J Rader, Svati H Shah, Dan M Roden, Gregory M Marcus, Ruth J F Loos, Scott M Damrauer, Christopher M Haggerty, Kelly Cho, Aarno Palotie, Morten S Olesen, Lee L Eckhardt, Jason D Roberts, Michael J Cutler, M Benjamin Shoemaker, Peter W F Wilson, Patrick T Ellinor, Steven A Lubitz (2024). Meta-Analysis of Genome-Wide Association Studies Reveals Genetic Mechanisms of Supraventricular Arrhythmias. Circulation. Genomic and precision medicine, e004320. https://doi.org/10.1161/CIRCGEN.123.004320 PMID: 38804128",
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                ],
                [
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                ],
                [
                    "Nico Hartmann, Maria Knierim, Wiebke Maurer, Nataliya Dybkova, Gerd Hasenfuß, Samuel Sossalla, Katrin Streckfuss-Bömeke (2023). Molecular and Functional Relevance of NaV1.8-Induced Atrial Arrhythmogenic Triggers in a Human SCN10A Knock-Out Stem Cell Model. International journal of molecular sciences. https://doi.org/10.3390/ijms241210189 PMID: 37373335",
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                ],
                [
                    "Zhenxing Liao, Yingrui Li, Xuehui Fan, Zhen Yang, Ibrahim El-Battrawy, Xiaobo Zhou, Ibrahim Akin (2022). Lipopolysaccharide Modifies Sodium Current Kinetics through ROS and PKC Signalling in Induced Pluripotent Stem-Derived Cardiomyocytes from Brugada Syndrome Patient. Journal of cardiovascular development and disease. https://doi.org/10.3390/jcdd9040119 PMID: 35448095",
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                ],
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                ],
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                ],
                [
                    "Joyce C K Man, Fernanda M Bosada, Koen T Scholman, Joost A Offerhaus, Roddy Walsh, Karel van Duijvenboden, Vincent W W van Eif, Connie R Bezzina, Arie O Verkerk, Bastiaan J Boukens, Phil Barnett, Vincent M Christoffels (2021). Variant Intronic Enhancer Controls SCN10A-short Expression and Heart Conduction. Circulation, 229-242. https://doi.org/10.1161/CIRCULATIONAHA.121.054083 PMID: 33910361",
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                ],
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                ],
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                ],
                [
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                    "32619740"
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            ]
        ],
        [
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                "SCN10A",
                "Mexiletine"
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            [
                [
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}