{
    "nodes": [
        [
            "Immunoglobulin E",
            "DRUG"
        ],
        [
            "Allergic airway syndrome",
            "DISEASE"
        ],
        [
            "Interleukin 1 Receptor Antagonist Protein",
            "DRUG"
        ],
        [
            "mepolizumab",
            "DRUG"
        ],
        [
            "Nitric Oxide",
            "DRUG"
        ],
        [
            "Interferons",
            "DRUG"
        ],
        [
            "benralizumab",
            "DRUG"
        ],
        [
            "Interleukin-4",
            "DRUG"
        ],
        [
            "Omalizumab",
            "DRUG"
        ],
        [
            "Leukotriene Antagonists",
            "DRUG"
        ],
        [
            "IL5",
            "GENE"
        ],
        [
            "Interleukin-12",
            "DRUG"
        ],
        [
            "Immunoglobulin G",
            "DRUG"
        ]
    ],
    "edges": [
        [
            [
                "IL5",
                "Omalizumab"
            ],
            5.0346656,
            [
                [
                    "Yuuya Nishii, Takashi Kinoshita, Jun Sasaki, Shingo Tsuneyoshi, Kenichi Irie, Takahisa Tateishi, Masaki Tominaga, Takayuki Taniwaki, Tomoaki Hoshino, Tomotaka Kawayama (2025). Eosinophilic Meningoencephalitis Occurred during Oral Corticosteroid Tapering and after Switching from Anti-IL-5 to Anti-IgE Treatment. Internal medicine (Tokyo, Japan), 153-156. https://doi.org/10.2169/internalmedicine.2908-23 PMID: 38839336",
                    "38839336"
                ],
                [
                    "Rini Patadia, Thomas B Casale, John Fowler, Shiven Patel, Juan Carlos Cardet (2024). Advancements in biologic therapy in eosinophilic asthma. Expert opinion on biological therapy, 251-261. https://doi.org/10.1080/14712598.2024.2342527 PMID: 38619468",
                    "38619468"
                ],
                [
                    "Lina Mahmood, Sevdenur Keskin, Akilah A Jefferson (2024). Precision care in the treatment of pediatric asthma. Current opinion in pediatrics, 304-309. https://doi.org/10.1097/MOP.0000000000001343 PMID: 38411592",
                    "38411592"
                ],
                [
                    "Irina Bobolea, Jan Hagemann, Marek Sanak, Ludger Klimek, Joaquim Mullol (2024). Current Goals of NSAID-ERD Management: Patient-Centered Approaches Involving NSAID Desensitization With and Without Biologics. The journal of allergy and clinical immunology. In practice, 2934-2944. https://doi.org/10.1016/j.jaip.2024.09.012 PMID: 39306329",
                    "39306329"
                ],
                [
                    "Selcen Hoşgören-Tekin, İrem Peker Eyüboğlu, Mustafa Akkiprik, Ana Maria Giménez-Arnau, Andaç Salman (2024). Inflammatory cytokine levels and changes during omalizumab treatment in chronic spontaneous urticaria. Archives of dermatological research, 261. https://doi.org/10.1007/s00403-024-02966-6 PMID: 38795119",
                    "38795119"
                ],
                [
                    "Andrea Dionelly Murillo, Ana Isabel Castrillon, Carlos Daniel Serrano, Liliana Fernandez-Trujillo (2024). Monoclonal antibodies in idiopathic chronic eosinophilic pneumonia: a scoping review. BMC pulmonary medicine, 74. https://doi.org/10.1186/s12890-024-02868-3 PMID: 38331769",
                    "38331769"
                ],
                [
                    "Justin D Salciccioli, Elliot Israel (2024). Asthma Biologics: Lung Function, Steroid-Dependence, and Exacerbations. Immunology and allergy clinics of North America, 693-708. https://doi.org/10.1016/j.iac.2024.08.002 PMID: 39389718",
                    "39389718"
                ],
                [
                    "Aleksandra Plavsic, Branka Bonaci-Nikolic, Branislava Milenkovic, Rada Miskovic, Natasa Kusic, Milan Dimitrijevic, Snezana Arandjelovic, Katarina Milosevic, Ivana Buha, Vesna Tomic Spiric (2024). Asthma Inflammatory Phenotypes: How Can We Distinguish Them? Journal of clinical medicine. https://doi.org/10.3390/jcm13020526 PMID: 38256660",
                    "38256660"
                ],
                [
                    "Alexander Eggel, Luke F Pennington, Theodore S Jardetzky (2024). Therapeutic monoclonal antibodies in allergy: Targeting IgE, cytokine, and alarmin pathways. Immunological reviews, 387-411. https://doi.org/10.1111/imr.13380 PMID: 39158477",
                    "39158477"
                ],
                [
                    "Bilal Malik, Nathan W Bartlett, John W Upham, Kristy S Nichol, John Harrington, Peter A B Wark (2023). Severe asthma ILC2s demonstrate enhanced proliferation that is modified by biologics. Respirology (Carlton, Vic.), 758-766. https://doi.org/10.1111/resp.14506 PMID: 37114915",
                    "37114915"
                ]
            ]
        ],
        [
            [
                "Allergic airway syndrome",
                "IL5"
            ],
            2.345436,
            [
                [
                    "Gert-Jan Braunstahl (2009). United airways concept: what does it teach us about systemic inflammation in airways disease? Proceedings of the American Thoracic Society, 652-4. https://doi.org/10.1513/pats.200906-052DP PMID: 20008869",
                    "20008869"
                ]
            ]
        ],
        [
            [
                "IL5",
                "Interleukin-4"
            ],
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            [
                [
                    "Metin Yesiltepe, Tao Yin, Marc Tambini, Hanmei Bao, Meixia Pan, Cristina d'Abramo, Luca Giliberto, Xianlin Han, Luciano D'Adamio (2024). Analysis of early effects of human APOE isoforms on Alzheimer's disease and type III hyperlipoproteinemia pathways using knock-in rat models with humanized APP and APOE. Cell communication and signaling : CCS, 458. https://doi.org/10.1186/s12964-024-01832-2 PMID: 39334477",
                    "39334477"
                ],
                [
                    "Jue Wang, Yuanyuan Wu, Xiao Li, Xinghui Wang, Shuanying Yang (2024). Bergapten inhibits airway inflammation and MRGPRX2-mediated mast cells activation by targeting NR4A1. International immunopharmacology, 111798. https://doi.org/10.1016/j.intimp.2024.111798 PMID: 38442583",
                    "38442583"
                ],
                [
                    "Wenzhi Zhan, Wei Luo, Yulong Zhang, Keheng Xiang, Xiaomei Chen, Shuirong Shen, Chuqing Huang, Tingting Xu, Wenbin Ding, Yuehan Chen, Mingtong Lin, Xinghua Pan, Kefang Lai (2024). Sputum Transcriptomics Reveals FCN1+ Macrophage Activation in Mild Eosinophilic Asthma Compared to Non-Asthmatic Eosinophilic Bronchitis. Allergy, asthma & immunology research, 55-70. https://doi.org/10.4168/aair.2024.16.1.55 PMID: 38262391",
                    "38262391"
                ],
                [
                    "Xianhai Zeng, Juanjuan Li, Jiangqi Liu, Lihua Mo, Yu Liu, Aizhi Zhang, Pingchang Yang, Hui Kong (2024). Nasal mucosal fibroblasts produce IL-4 to induce Th2 response. Innate immunity, 55-65. https://doi.org/10.1177/17534259241254623 PMID: 38725177",
                    "38725177"
                ],
                [
                    "Martina Protschka, Daniela Di Placido, Peter F Moore, Mathias Büttner, Gottfried Alber, Maria Eschke (2024). Canine peripheral non-conventional TCRαβ+ CD4-CD8α- double-negative T cells show T helper 2-like and regulatory properties. Frontiers in immunology, 1400550. https://doi.org/10.3389/fimmu.2024.1400550 PMID: 38835756",
                    "38835756"
                ],
                [
                    "Sara Puente-Marin, Fabrícia Dietrich, Peter Achenbach, Hugo Barcenilla, Johnny Ludvigsson, Rosaura Casas (2023). Intralymphatic glutamic acid decarboxylase administration in type 1 diabetes patients induced a distinctive early immune response in patients with DR3DQ2 haplotype. Frontiers in immunology, 1112570. https://doi.org/10.3389/fimmu.2023.1112570 PMID: 36817467",
                    "36817467"
                ],
                [
                    "Ozge Yilmaz, Seda Tunca, Adem Yasar, Merve Ocalan, Fatma Taneli, Hasan Yuksel (2023). Inflammatory markers in exhaled breath condensate in nonasthmatic children with food allergy. Journal of breath research. https://doi.org/10.1088/1752-7163/ad02b5 PMID: 37827149",
                    "37827149"
                ],
                [
                    "Yangfan Hou, Shuping Zheng, Fan Zou, Dan Wang, Hongju Da, Yong Zhou, Xinping Fan, Jianghao Liu, Hongyan Zhao, Jin He, Hongxin Li, Xiuzhen Sun, Yun Liu (2023). Lactobacillus rhamnosus 76 alleviates airway inflammation in ovalbumin-allergic mice and improves mucus secretion by down-regulating STAT6/SPDEF pathway. Immunobiology, 152712. https://doi.org/10.1016/j.imbio.2023.152712 PMID: 37515878",
                    "37515878"
                ],
                [
                    "René Camas-Pereyra, Génesis A Bautista-García, Guillermina Avila, Yazmin Alcala-Canto, Jocelyn Maza-Lopez, David E Reyes-Guerrero, Rosa Isabel Higuera-Piedrahita, María Eugenia López-Arellano (2023). In silico analysis of two Haemonchus spp. serine protease peptides (S28) and their immunomodulatory activity in vitro. Molecular and biochemical parasitology, 111545. https://doi.org/10.1016/j.molbiopara.2023.111545 PMID: 36681328",
                    "36681328"
                ],
                [
                    "Geneviève Pelletier, Krystelle Godbout, Marie-Ève Boulay, Louis-Philippe Boulet, Mathieu C Morissette, Andréanne Côté (2022). Increase in FeNO Levels Following IL5/IL5R-Targeting Therapies in Severe Asthma: A Case Series. Journal of asthma and allergy, 691-701. https://doi.org/10.2147/JAA.S358877 PMID: 35615256",
                    "35615256"
                ]
            ]
        ],
        [
            [
                "IL5",
                "Nitric Oxide"
            ],
            5.90991,
            [
                [
                    "Li Zhang, Alimire Aierken, Ran Dong, Mengru Zhang, Qiang Chen, Zhongmin Qiu (2025). Comparison of airway inflammation characteristics detected by lower exhaled nitric oxide in cough variant asthma, non-asthmatic eosinophilic bronchitis, and classic asthma. The Journal of asthma : official journal of the Association for the Care of Asthma, 1-10. https://doi.org/10.1080/02770903.2024.2444319 PMID: 39693523",
                    "39693523"
                ],
                [
                    "Rebecca J Ainslie, Ioannis Simitsidellis, Phoebe M Kirkwood, Douglas A Gibson (2024). RISING STARS: Androgens and immune cell function. The Journal of endocrinology. PMID: 38579776",
                    "38579776"
                ],
                [
                    "Taiyu Song, Lulu Yao, Angang Zhu, Guangling Liu, Beibei Zhu, Qian Zhao, Yue Zhao, Jinya Wang (2024). Cathepsin B-Activatable Bioactive Peptide Nanocarrier for High-Efficiency Immunotherapy of Asthma. International journal of nanomedicine, 8059-8070. https://doi.org/10.2147/IJN.S455633 PMID: 39130687",
                    "39130687"
                ],
                [
                    "Mohamed H Taki, Kristine E Lee, Ronald Gangnon, James E Gern, Robert F Lemanske, Daniel J Jackson, Anne Marie Singh (2024). Atopic dermatitis phenotype affects expression of atopic diseases despite similar mononuclear cell cytokine response. The Journal of allergy and clinical immunology, 1604-1610.e2. https://doi.org/10.1016/j.jaci.2024.02.015 PMID: 38438085",
                    "38438085"
                ],
                [
                    "Florence Schleich, Catherine Moermans, Sara Gerday, Stéphanie Ziant, Gilles Louis, Nicolas Bougard, Virginie Paulus, Françoise Guissard, Monique Henket, Claus Bachert, Renaud Louis (2023). Patients With Asthma Only Sensitized to Staphylococcus aureus Enterotoxins Have More Exacerbations, Airflow Limitation, and Higher Levels of Sputum IL-5 and IgE. The journal of allergy and clinical immunology. In practice, 3055-3061.e4. https://doi.org/10.1016/j.jaip.2023.05.043 PMID: 37301436",
                    "37301436"
                ],
                [
                    "H S Rohith, Muthukumar Serva Peddha, Prakash Motiram Halami (2023). Probiotic Bacillus licheniformis MCC2514 and Bifidobacterium breve NCIM 5671 Regulates GATA3 and Foxp3 Expression in the Elevated Disease Condition. Probiotics and antimicrobial proteins. https://doi.org/10.1007/s12602-023-10080-8 PMID: 37195508",
                    "37195508"
                ],
                [
                    "Morteza Saeedavi, Mehdi Goudarzi, Saeed Mehrzadi, Zahra Basir, Ali Hasanvand, Azam Hosseinzadeh (2022). Sinapic acid ameliorates airway inflammation in murine ovalbumin-induced allergic asthma by reducing Th2 cytokine production. Life sciences, 120858. https://doi.org/10.1016/j.lfs.2022.120858 PMID: 35931198",
                    "35931198"
                ],
                [
                    "Matheus Augusto Souza, Elda Gonçalves-Santos, Reggiani V Gonçalves, Eliziária C Santos, Camila C Campos, Marcos J Marques, Raquel L M Souza, Rômulo D Novaes (2022). Doxycycline hyclate stimulates inducible nitric oxide synthase and arginase imbalance, potentiating inflammatory and oxidative lung damage in schistosomiasis. Biomedical journal, 857-869. https://doi.org/10.1016/j.bj.2021.12.007 PMID: 34971826",
                    "34971826"
                ],
                [
                    "Philipp Würzner, Rudolf A Jörres, Stefan Karrasch, Caroline Quartucci, Stephan Böse-O'Reilly, Dennis Nowak, Stefan Rakete (2022). Effect of experimental exposures to 3-D printer emissions on nasal allergen responses and lung diffusing capacity for inhaled carbon monoxide/nitric oxide in subjects with seasonal allergic rhinitis. Indoor air, e13174. https://doi.org/10.1111/ina.13174 PMID: 36437663",
                    "36437663"
                ],
                [
                    "Youngsoo Lee, Quang Luu Quoc, Hae Sim Park (2021). Biomarkers for Severe Asthma: Lessons From Longitudinal Cohort Studies. Allergy, asthma & immunology research, 375-389. https://doi.org/10.4168/aair.2021.13.3.375 PMID: 33733634",
                    "33733634"
                ]
            ]
        ],
        [
            [
                "IL5",
                "Interleukin 1 Receptor Antagonist Protein"
            ],
            5.334293000000001,
            [
                [
                    "Neil P Monaghan, Sunny Shah, Brian A Keith, Shaun A Nguyen, Danforth A Newton, John E Baatz, Carol L Wagner, Habib G Rizk (2025). Proinflammatory Cytokine Profiles in Menière's Disease and Vestibular Migraine. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 88-95. https://doi.org/10.1097/MAO.0000000000004372 PMID: 39627868",
                    "39627868"
                ],
                [
                    "Jowita Adamczyk-Zostawa, Adam Wylęgała, Martyna Lis, Jacek Zostawa, Rafał Fiolka, Edward Wylęgała, Monika Adamczyk-Sowa, Zenon Czuba (2024). The level of cytokines in tears as a novel indicator of demyelinating diseases. Neurological research, 487-494. https://doi.org/10.1080/01616412.2024.2337502 PMID: 38602307",
                    "38602307"
                ],
                [
                    "Rongrong Zeng, Lu He, Zhuo Kuang, Yiemin Jian, Meijuan Qiu, Yuting Liu, Mengdie Hu, Yizhi Ye, Liwen Wu (2024). Clinical characteristics, immunological alteration and distinction of MOG-IgG-associated disorders and GFAP-IgG-associated disorders. Journal of neuroimmunology, 578398. https://doi.org/10.1016/j.jneuroim.2024.578398 PMID: 39002186",
                    "39002186"
                ],
                [
                    "Ettore Dolcetti, Fabio Buttari, Antonio Bruno, Federica Azzolini, Luana Gilio, Angela Borrelli, Veronica Di Caprio, Gianluca Lauritano, Giovanni Galifi, Stefano Gambardella, Rosangela Ferese, Emiliano Giardina, Valentina Rovella, Roberto Furlan, Annamaria Finardi, Alessandra Musella, Sara Balletta, Georgia Mandolesi, Diego Centonze, Mario Stampanoni Bassi (2024). An IL-5 Single-Nucleotide Polymorphism Influences Neuroinflammation and Prospective Disease Activity in Multiple Sclerosis. International journal of molecular sciences. https://doi.org/10.3390/ijms25169108 PMID: 39201794",
                    "39201794"
                ],
                [
                    "Anuradha Rajamanickam, Pavan Kumar Nathella, Aishwarya Venkataraman, Padmapriyadarsini Chandrasekaran, Sasidaran Rajendraprasath, Bella D Devaleenal, Arul Nancy Pandiarajan, Gowshika Krishnakumar, Padmasani Venkat Ramanan, Subash Babu (2024). Elucidating systemic immune responses to acute and convalescent SARS-CoV-2 infection in children and elderly individuals. Immunity, inflammation and disease, e1167. https://doi.org/10.1002/iid3.1167 PMID: 38415923",
                    "38415923"
                ],
                [
                    "E N Trushina, N A Riger, O K Mustafina, A N Timonin, T N Solntseva, I S Zilova, I V Kobelkova, D B Nikityuk (2024). [Multi-strain probiotic combined with dietary fiber is an effective factor in the nutritional support of immunity in athletes]. Voprosy pitaniia, 19-30. https://doi.org/10.33029/0042-8833-2024-93-2-19-30 PMID: 38809796",
                    "38809796"
                ],
                [
                    "Fan Yu, Emma Bishop, Fabio Miazzi, Rhian Evans, David Smart, Damien Breheny, David Thorne (2024). Multi-endpoint in vitro toxicological assessment of snus and tobacco-free nicotine pouch extracts. Mutation research. Genetic toxicology and environmental mutagenesis, 503738. https://doi.org/10.1016/j.mrgentox.2024.503738 PMID: 38575247",
                    "38575247"
                ],
                [
                    "Lifan Zhang, Zhengrong Yang, Fengying Wu, Qiping Ge, Yueqiu Zhang, Dongyu Li, Mengqiu Gao, Xiaoqing Liu (2024). Multiple cytokine analysis based on QuantiFERON-TB gold plus in different tuberculosis infection status: an exploratory study. BMC infectious diseases, 28. https://doi.org/10.1186/s12879-023-08943-0 PMID: 38166667",
                    "38166667"
                ],
                [
                    "Muhammad Farooq Rai, Lei Cai, Nobuaki Chinzei, Eric J Schmidt, Omer Yousuf, Farshid Guilak, Robert H Brophy (2024). Distinct patterns of cytokines, chemokines, and growth factors in synovial fluid after ACL injury in comparison to osteoarthritis. Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 1448-1462. https://doi.org/10.1002/jor.25794 PMID: 38294185",
                    "38294185"
                ],
                [
                    "Beatrice Fageräng, Corinna Lau, Karin Ekholt Mc Adam, Camilla Schjalm, Dorte Christiansen, Peter Garred, Per H Nilsson, Tom Eirik Mollnes (2023). A novel selective leukocyte depletion human whole blood model reveals the specific roles of monocytes and granulocytes in the cytokine response to Escherichia coli. Journal of leukocyte biology. https://doi.org/10.1093/jleuko/qiad151 PMID: 38057165",
                    "38057165"
                ]
            ]
        ],
        [
            [
                "IL5",
                "mepolizumab"
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            18.77773,
            [
                [
                    "Tomonori Ishii, Hideaki Kunishige, Tamami Kobayashi, Etsuko Hayashi, Masaki Komatsubara, Rafael Alfonso-Cristancho, Jun Tamaoki, Peter Howarth (2024). Real-world safety and effectiveness of mepolizumab for patients with eosinophilic granulomatosis with polyangiitis in Japan: long-term observation of the MARS study. Modern rheumatology. https://doi.org/10.1093/mr/roae100 PMID: 39508562",
                    "39508562"
                ],
                [
                    "Michael E Wechsler, Ying Fan, Peter A Merkel (2024). Benralizumab versus Mepolizumab for Eosinophilic Granulomatosis with Polyangiitis. Reply. The New England journal of medicine, 1940. PMID: 38810204",
                    "38810204"
                ],
                [
                    "Katarzyna Antosz, Joanna Batko, Marta Błażejewska, Antoni Gawor, Jakub Sleziak, Krzysztof Gomułka (2024). Insight into IL-5 as a Potential Target for the Treatment of Allergic Diseases. Biomedicines. https://doi.org/10.3390/biomedicines12071531 PMID: 39062104",
                    "39062104"
                ],
                [
                    "Chrong-Reen Wang, Hung-Wen Tsai, Chi-Chang Shieh (2024). Monocentric study of IL-5 monoclonal antibody induction therapy for eosinophilic granulomatosis with polyangiitis. Journal of the Formosan Medical Association = Taiwan yi zhi, 802-810. https://doi.org/10.1016/j.jfma.2024.01.007 PMID: 38199911",
                    "38199911"
                ],
                [
                    "Michael Fricker, John Harrington, Sarah A Hiles, Peter G Gibson (2024). Mepolizumab depletes inflammatory but preserves homeostatic eosinophils in severe asthma. Allergy, 3118-3128. https://doi.org/10.1111/all.16267 PMID: 39115364",
                    "39115364"
                ],
                [
                    "Lauren Worth, Ali Khreisat, Angela Iacobelli (2024). Successful Treatment of Relapsing Chronic Eosinophilic Pneumonia With Mepolizumab: A Case Report. Cureus, e65097. https://doi.org/10.7759/cureus.65097 PMID: 39040614",
                    "39040614"
                ],
                [
                    "Gabriella E Wilson, Samir Gautam, Geoffrey L Chupp (2024). Does Eosinophil Heterogeneity Translate into Functional Diversity? A Review of the Evolving Paradigm of Eosinophil Heterogeneity in Asthma. Biomedicines. https://doi.org/10.3390/biomedicines12092011 PMID: 39335525",
                    "39335525"
                ],
                [
                    "Justin D Salciccioli, Elliot Israel (2024). Asthma Biologics: Lung Function, Steroid-Dependence, and Exacerbations. Immunology and allergy clinics of North America, 693-708. https://doi.org/10.1016/j.iac.2024.08.002 PMID: 39389718",
                    "39389718"
                ],
                [
                    "Takashi Yamane, Akira Hashiramoto (2024). Solo Addition of Mepolizumab Turned Antineutrophil Cytoplasmic Antibody Negative and Achieved Glucocorticoid Discontinuation in a Patient with Eosinophilic Granulomatosis with Polyangiitis: A Case Report. Internal medicine (Tokyo, Japan). https://doi.org/10.2169/internalmedicine.4130-24 PMID: 39370255",
                    "39370255"
                ],
                [
                    "Foteini Ioakeim, Christophe Abellan, Alessio Casutt, Benoit Lechartier, Leslie Noirez, Catherine Beigelman-Aubry, John-David Aubert, Zisis Balmpouzis, Angela Koutsokera (2024). Allergic bronchopulmonary aspergillosis in a lung transplant recipient treated with mepolizumab. Clinical immunology (Orlando, Fla.), 110265. https://doi.org/10.1016/j.clim.2024.110265 PMID: 38801928",
                    "38801928"
                ]
            ]
        ],
        [
            [
                "IL5",
                "Immunoglobulin E"
            ],
            7.0905536,
            [
                [
                    "Alexander Eggel, Luke F Pennington, Theodore S Jardetzky (2024). Therapeutic monoclonal antibodies in allergy: Targeting IgE, cytokine, and alarmin pathways. Immunological reviews, 387-411. https://doi.org/10.1111/imr.13380 PMID: 39158477",
                    "39158477"
                ],
                [
                    "Jyostna Mullur, Kathleen M Buchheit (2023). Aspirin-exacerbated respiratory disease: Updates in the era of biologics. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 317-324. https://doi.org/10.1016/j.anai.2023.05.016 PMID: 37225000",
                    "37225000"
                ],
                [
                    "Camila Carla Guimarães, Camila Mira Sandy, Rebeca Figueira, Mirani da Rocha Gonçalves, Eduardo José Crevelin, Pedro Henrique Cardoso, Alexandre Todorovic Fabro, Fabio Carmona, Marcos de Carvalho Borges, Ana Maria Soares Pereira (2023). Anti-asthmatic activity of standardized hydro-ethanolic and aqueous extracts of Stachytarpheta cayennensis (Rich.) Vahl in a murine model. Journal of ethnopharmacology, 115877. https://doi.org/10.1016/j.jep.2022.115877 PMID: 36336223",
                    "36336223"
                ],
                [
                    "Mihi Yang, Unjae Lee, Hye-Rin Cho, Kyung Bae Lee, Yun Jeoung Shin, Min-Jung Bae, Kun-Young Park (2023). Effects of Pear Extracts on Microbiome and Immunocytokines to Alleviate Air Pollution-Related Respiratory Hypersensitivity. Journal of medicinal food, 211-214. https://doi.org/10.1089/jmf.2022.K.0117 PMID: 36856473",
                    "36856473"
                ],
                [
                    "Lisa Buchenauer, Kristin M Junge, Sven-Bastiaan Haange, Jan C Simon, Martin von Bergen, Anna-Lena Hoh, Gabriela Aust, Ana C Zenclussen, Gabriele I Stangl, Tobias Polte (2022). Glyphosate differentially affects the allergic immune response across generations in mice. The Science of the total environment, 157973. https://doi.org/10.1016/j.scitotenv.2022.157973 PMID: 35963408",
                    "35963408"
                ],
                [
                    "Yuhang Wang, Jin Wang, Li Chen, Huan Zhang, Ling Yu, Yulong Chi, Mengli Chen, Yun Cai (2022). Efficacy of vitamin D supplementation on COPD and asthma control: A systematic review and meta-analysis. Journal of global health, 04100. https://doi.org/10.7189/jogh.12.04100 PMID: 36520525",
                    "36520525"
                ],
                [
                    "Ya-Qin Chen, Yan Zhou, Qi-Li Wang, Jian Chen, Hua Chen, Hui-Hui Xie, Lan Li (2022). Conciliatory Anti-Allergic Decoction Attenuates Pyroptosis in RSV-Infected Asthmatic Mice and Lipopolysaccharide (LPS)-Induced 16HBE Cells by Inhibiting TLR3/NLRP3/NF-κB/IRF3 Signaling Pathway. Journal of immunology research, 1800401. https://doi.org/10.1155/2022/1800401 PMID: 36213326",
                    "36213326"
                ],
                [
                    "Sabrina S Ferreira, Maria A Oliveira, Maristela Tsujita, Fernanda P B Nunes, Felipe B Casagrande, Eliane Gomes, Momtchilo Russo, Wothan Tavares de Lima, Joilson O Martins (2020). Insulin Modulates the Immune Cell Phenotype in Pulmonary Allergic Inflammation and Increases Pulmonary Resistance in Diabetic Mice. Frontiers in immunology, 84. https://doi.org/10.3389/fimmu.2020.00084 PMID: 32117245",
                    "32117245"
                ],
                [
                    "Zhicheng Zhang, Haoran Kang (2020). Protective effect of Asarum sieboldii essential oil on ovalbumin induced allergic rhinitis in rat. Bioscience reports. https://doi.org/10.1042/BSR20191370 PMID: 32395767",
                    "32395767"
                ],
                [
                    "Corrado Pelaia, Claudia Crimi, Alessandro Vatrella, Caterina Tinello, Rosa Terracciano, Girolamo Pelaia (2020). Molecular Targets for Biological Therapies of Severe Asthma. Frontiers in immunology, 603312. https://doi.org/10.3389/fimmu.2020.603312 PMID: 33329598",
                    "33329598"
                ]
            ]
        ],
        [
            [
                "IL5",
                "Immunoglobulin G"
            ],
            6.432608200000001,
            [
                [
                    "Nelli K Akhmatova, Ekaterina A Kurbatova, Anton E Zaytsev, Elina A Akhmatova, Natalya E Yastrebova, Elena V Sukhova, Dmitriy V Yashunsky, Yury E Tsvetkov, Nikolay E Nifantiev (2024). Synthetic BSA-conjugated disaccharide related to the Streptococcus pneumoniae serotype 3 capsular polysaccharide increases IL-17A Levels, γδ T cells, and B1 cells in mice. Frontiers in immunology, 1388721. https://doi.org/10.3389/fimmu.2024.1388721 PMID: 38840926",
                    "38840926"
                ],
                [
                    "Xiaofeng Li, Zhixun Xie, You Wei, Meng Li, Minxiu Zhang, Sisi Luo, Liji Xie (2024). Recombinant Hemagglutinin Protein from H9N2 Avian Influenza Virus Exerts Good Immune Effects in Mice. Microorganisms. https://doi.org/10.3390/microorganisms12081552 PMID: 39203394",
                    "39203394"
                ],
                [
                    "S Hasan Kadhum Al-Huchaimi, G Hameed Neamah Al-Kefaei, B Ahmed Alameedy (2022). Effects of Toxoplasma gondii on Levels of Interleukin-5 in Parkinson's Patients. Archives of Razi Institute, 213-220. https://doi.org/10.22092/ARI.2021.356478.1850 PMID: 35891730",
                    "35891730"
                ],
                [
                    "Mako Numazaki, Masaki Abe, Kaori Hanaoka, Emiko Imamura, Masashi Maeda, Akihiko Kimura, Jun Miyanohara, Tetsu Saito, Kazunori Arai, Hiroshi Suzuki, Yuji Saita (2022). ASP7266, a Novel Antibody against Human Thymic Stromal Lymphopoietin Receptor for the Treatment of Allergic Diseases. The Journal of pharmacology and experimental therapeutics, 26-33. https://doi.org/10.1124/jpet.121.000686 PMID: 34728559",
                    "34728559"
                ],
                [
                    "Paul R Chapman, Rebecca Webster, Paul Giacomin, Stacey Llewellyn, Luke Becker, Mark S Pearson, Fabian De Labastida Rivera, Peter O'Rourke, Christian R Engwerda, Alex Loukas, James S McCarthy (2021). Vaccination of human participants with attenuated Necator americanus hookworm larvae and human challenge in Australia: a dose-finding study and randomised, placebo-controlled, phase 1 trial. The Lancet. Infectious diseases, 1725-1736. https://doi.org/10.1016/S1473-3099(21)00153-5 PMID: 34419209",
                    "34419209"
                ],
                [
                    "Qian Zhang, Guangpeng Xi, Jia Yin (2021). Artemisia sieversiana pollen allergy and immunotherapy in mice. American journal of translational research, 13654-13664. PMID: 35035704",
                    "35035704"
                ],
                [
                    "Xiaobo Long, Nan Wang, Xinhao Zhang (2021). Roles of Clara cell 10-kD protein and type 2 innate lymphoid cells in allergic rhinitis. Cell cycle (Georgetown, Tex.), 1923-1934. https://doi.org/10.1080/15384101.2021.1966961 PMID: 34437822",
                    "34437822"
                ],
                [
                    "Sabrina S Ferreira, Maria A Oliveira, Maristela Tsujita, Fernanda P B Nunes, Felipe B Casagrande, Eliane Gomes, Momtchilo Russo, Wothan Tavares de Lima, Joilson O Martins (2020). Insulin Modulates the Immune Cell Phenotype in Pulmonary Allergic Inflammation and Increases Pulmonary Resistance in Diabetic Mice. Frontiers in immunology, 84. https://doi.org/10.3389/fimmu.2020.00084 PMID: 32117245",
                    "32117245"
                ],
                [
                    "Leroy Versteeg, Junfei Wei, Zhuyun Liu, Brian Keegan, Ricardo T Fujiwara, Kathryn M Jones, Oluwatoyin Asojo, Ulrich Strych, Maria Elena Bottazzi, Peter J Hotez, Bin Zhan (2020). Protective immunity elicited by the nematode-conserved As37 recombinant protein against Ascaris suum infection. PLoS neglected tropical diseases, e0008057. https://doi.org/10.1371/journal.pntd.0008057 PMID: 32053593",
                    "32053593"
                ],
                [
                    "Carlos D Zappia, Ariadna Soto, Gina Granja-Galeano, Ignacio Fenoy, Natalia Fernandez, Carlos A Davio, Carina Shayo, Carlos P Fitzsimons, Alejandra Goldman, Federico Monczor (2019). Azelastine potentiates antiasthmatic dexamethasone effect on a murine asthma model. Pharmacology research & perspectives, e00531. https://doi.org/10.1002/prp2.531 PMID: 31687162",
                    "31687162"
                ]
            ]
        ],
        [
            [
                "IL5",
                "Interferons"
            ],
            6.374602,
            [
                [
                    "Y Lu, J Hong, H L Dou, B K Ma, C G Wang (2024). [Clinical characteristics of acute macular neuroretinopathy in China associated with COVID-19 infection]. [Zhonghua yan ke za zhi] Chinese journal of ophthalmology, 611-617. https://doi.org/10.3760/cma.j.cn112142-20231117-00237 PMID: 38955763",
                    "38955763"
                ],
                [
                    "Anna Machalińska, Agnieszka Kuligowska, Alicja Ziontkowska-Wrzałek, Beata Stroynowska, Ewa Pius-Sadowska, Krzysztof Safranow, Jan Machaliński, Katarzyna Mozolewska-Piotrowska, Bogusław Machaliński (2024). The Severity of Diabetic Retinopathy Corresponds with Corneal Nerve Alterations and Ocular Discomfort of the Patient. International journal of molecular sciences. https://doi.org/10.3390/ijms25116072 PMID: 38892258",
                    "38892258"
                ],
                [
                    "Jung Ok Lee, Youna Jang, A Yeon Park, Jung Min Lee, Kyeongsoo Jeong, So-Hyun Jeon, Hui Jin, Minju Im, Jae-Won Kim, Beom Joon Kim (2024). Human Placenta Extract (HPH) Suppresses Inflammatory Responses in TNF-α/IFN-γ-Stimulated HaCaT Cells and a DNCB Atopic Dermatitis (AD)-Like Mouse Model. Journal of microbiology and biotechnology, 1969-1980. https://doi.org/10.4014/jmb.2406.06045 PMID: 39252632",
                    "39252632"
                ],
                [
                    "Andreas Glässner, Gerda Wurpts, Stefanie Röseler, Amir S Yazdi, Christine Krämer, Amol Fatangare, Albert Sickmann, Per Hoffmann, Markus Nöthen, Bernhardt Sachs (2023). IFN-γ secretion of PBMC from non-drug-allergic control persons: Considerations for the validity of a positive lymphocyte transformation test. Journal of immunological methods, 113515. https://doi.org/10.1016/j.jim.2023.113515 PMID: 37331693",
                    "37331693"
                ],
                [
                    "Zichao Luo, Xiuqi Liang, Tao He, Xian Qin, Xinchao Li, Yueshan Li, Lu Li, Xian Jun Loh, Changyang Gong, Xiaogang Liu (2022). Lanthanide-Nucleotide Coordination Nanoparticles for STING Activation. Journal of the American Chemical Society, 16366-16377. https://doi.org/10.1021/jacs.2c03266 PMID: 36037283",
                    "36037283"
                ],
                [
                    "Hwa Young Lee, Jung Hur, Ji Young Kang, Chin Kook Rhee, Sook Young Lee (2021). MicroRNA-21 Inhibition Suppresses Alveolar M2 Macrophages in an Ovalbumin-Induced Allergic Asthma Mice Model. Allergy, asthma & immunology research, 312-329. https://doi.org/10.4168/aair.2021.13.2.312 PMID: 33474864",
                    "33474864"
                ],
                [
                    "Yvette Z Szabo, Danica C Slavish, Jennifer E Graham-Engeland (2020). The effect of acute stress on salivary markers of inflammation: A systematic review and meta-analysis. Brain, behavior, and immunity, 887-900. https://doi.org/10.1016/j.bbi.2020.04.078 PMID: 32371089",
                    "32371089"
                ],
                [
                    "Ayako Okita, Yusuke Murakami, Shotaro Shimokawa, Jun Funatsu, Kohta Fujiwara, Shunji Nakatake, Yoshito Koyanagi, Masato Akiyama, Atsunobu Takeda, Toshio Hisatomi, Yasuhiro Ikeda, Koh-Hei Sonoda (2020). Changes of Serum Inflammatory Molecules and Their Relationships with Visual Function in Retinitis Pigmentosa. Investigative ophthalmology & visual science, 30. https://doi.org/10.1167/iovs.61.11.30 PMID: 32936303",
                    "32936303"
                ],
                [
                    "Xinran He, Wangen Li, Yunliang Xie, Yunjuan Zhao (2020). Long-term inhibition of dipeptidyl-peptidase 4 reduces islet infiltration and downregulates IL-1β and IL-12 in NOD mice. International immunopharmacology, 106945. https://doi.org/10.1016/j.intimp.2020.106945 PMID: 33182020",
                    "33182020"
                ],
                [
                    "Francesca Scatozza, Federica Moschella, Daniela D'Arcangelo, Stefania Rossi, Claudio Tabolacci, Claudia Giampietri, Enrico Proietti, Francesco Facchiano, Antonio Facchiano (2020). Nicotinamide inhibits melanoma in vitro and in vivo. Journal of experimental & clinical cancer research : CR, 211. https://doi.org/10.1186/s13046-020-01719-3 PMID: 33028392",
                    "33028392"
                ]
            ]
        ],
        [
            [
                "Allergic airway syndrome",
                "Leukotriene Antagonists"
            ],
            2.345436,
            [
                [
                    "Enrico Compalati, Erminia Ridolo, Giovanni Passalacqua, Fulvio Braido, Elisa Villa, Giorgio Walter Canonica (2010). The link between allergic rhinitis and asthma: the united airways disease. Expert review of clinical immunology, 413-23. https://doi.org/10.1586/eci.10.15 PMID: 20441427",
                    "20441427"
                ]
            ]
        ],
        [
            [
                "IL5",
                "Interleukin-12"
            ],
            19.559630000000002,
            [
                [
                    "Yuanjian Fang, Yibo Liu, Luxi Chen, Junjie Wang, Jiahao Zhang, Haocheng Zhang, Sixuan Tian, Anke Zhang, Jianmin Zhang, John H Zhang, Xiaoyu Wang, Jun Yu, Sheng Chen (2024). Cerebrospinal fluid markers of neuroinflammation and coagulation in severe cerebral edema and chronic hydrocephalus after subarachnoid hemorrhage: a prospective study. Journal of neuroinflammation, 237. https://doi.org/10.1186/s12974-024-03236-y PMID: 39334416",
                    "39334416"
                ],
                [
                    "Sahar Essa, Hussain A Safar, Raj Raghupathy (2024). Cytokine responses to major human Cytomegalovirus antigens in mouse model. Cytokine, 156546. https://doi.org/10.1016/j.cyto.2024.156546 PMID: 38359558",
                    "38359558"
                ],
                [
                    "Anna Machalińska, Agnieszka Kuligowska, Alicja Ziontkowska-Wrzałek, Beata Stroynowska, Ewa Pius-Sadowska, Krzysztof Safranow, Jan Machaliński, Katarzyna Mozolewska-Piotrowska, Bogusław Machaliński (2024). The Severity of Diabetic Retinopathy Corresponds with Corneal Nerve Alterations and Ocular Discomfort of the Patient. International journal of molecular sciences. https://doi.org/10.3390/ijms25116072 PMID: 38892258",
                    "38892258"
                ],
                [
                    "Chan Sam Moon, Tae-Hong Lim, Junghwa Hong, Donggeun Sul, Nackhwan Kim (2023). Assessment of a Discogenic Pain Animal Model Induced by Applying Continuous Shear Force to Intervertebral Discs. Pain physician, E181-E189. PMID: 37192241",
                    "37192241"
                ],
                [
                    "Heng Deng, Jun Zhang, Xiancang Yuan (2022). The Effects of Phellodendron Decoction on Wound Healing of Anal Fistula after Anal Fistulotomy. Evidence-based complementary and alternative medicine : eCAM, 7363006. https://doi.org/10.1155/2022/7363006 PMID: 36016687",
                    "36016687"
                ],
                [
                    "Hong Euy Kim, Hyun Jung Shim, Chaeyong Jung, Il Seon Shin, Jae-Min Kim, Sook Jung Yun (2022). Correlations of psychological distress with plasma cytokine levels and gene mutations in acral and non-acral melanoma. Frontiers in psychiatry, 1024206. https://doi.org/10.3389/fpsyt.2022.1024206 PMID: 36405903",
                    "36405903"
                ],
                [
                    "Gulsun Memi, Burak Yazgan (2021). Adropin and spexin hormones regulate the systemic inflammation in adenine-induced chronic kidney failure in rat. The Chinese journal of physiology, 194-201. https://doi.org/10.4103/cjp.cjp_13_21 PMID: 34472450",
                    "34472450"
                ],
                [
                    "Flaviane Vieira-Santos, Thaís Leal-Silva, Luiza de Lima Silva Padrão, Ana Cristina Loiola Ruas, Denise Silva Nogueira, Lucas Kraemer, Fabrício Marcus Silva Oliveira, Marcelo Vidigal Caliari, Remo Castro Russo, Ricardo Toshio Fujiwara, Lilian Lacerda Bueno (2021). Concomitant experimental coinfection by Plasmodium berghei NK65-NY and Ascaris suum downregulates the Ascaris-specific immune response and potentiates Ascaris-associated lung pathology. Malaria journal, 296. https://doi.org/10.1186/s12936-021-03824-w PMID: 34210332",
                    "34210332"
                ],
                [
                    "Samantha McInally, Kristin Wall, Tianwei Yu, Rabindra Tirouvanziam, William Kilembe, Jill Gilmour, Susan A Allen, Eric Hunter (2021). Elevated levels of inflammatory plasma biomarkers are associated with risk of HIV infection. Retrovirology, 8. https://doi.org/10.1186/s12977-021-00552-6 PMID: 33731158",
                    "33731158"
                ],
                [
                    "Arzu Didem Yalcin, Ata Nevzat Yalcin (2021). Future perspective: biologic agents in patients with severe COVID-19. Immunopharmacology and immunotoxicology, 1-7. https://doi.org/10.1080/08923973.2020.1818770 PMID: 32883116",
                    "32883116"
                ]
            ]
        ],
        [
            [
                "IL5",
                "benralizumab"
            ],
            5.082037000000001,
            [
                [
                    "Sanjay Ramakrishnan, Richard E K Russell, Hafiz R Mahmood, Karolina Krassowska, James Melhorn, Christine Mwasuku, Ian D Pavord, Laura Bermejo-Sanchez, Imran Howell, Mahdi Mahdi, Stefan Peterson, Thomas Bengtsson, Mona Bafadhel (2025). Treating eosinophilic exacerbations of asthma and COPD with benralizumab (ABRA): a double-blind, double-dummy, active placebo-controlled randomised trial. The Lancet. Respiratory medicine, 59-68. https://doi.org/10.1016/S2213-2600(24)00299-6 PMID: 39615502",
                    "39615502"
                ],
                [
                    "Michael E Wechsler, Ying Fan, Peter A Merkel (2024). Benralizumab versus Mepolizumab for Eosinophilic Granulomatosis with Polyangiitis. Reply. The New England journal of medicine, 1940. PMID: 38810204",
                    "38810204"
                ],
                [
                    "Katarzyna Antosz, Joanna Batko, Marta Błażejewska, Antoni Gawor, Jakub Sleziak, Krzysztof Gomułka (2024). Insight into IL-5 as a Potential Target for the Treatment of Allergic Diseases. Biomedicines. https://doi.org/10.3390/biomedicines12071531 PMID: 39062104",
                    "39062104"
                ],
                [
                    "Michael Fricker, John Harrington, Sarah A Hiles, Peter G Gibson (2024). Mepolizumab depletes inflammatory but preserves homeostatic eosinophils in severe asthma. Allergy, 3118-3128. https://doi.org/10.1111/all.16267 PMID: 39115364",
                    "39115364"
                ],
                [
                    "Justin D Salciccioli, Elliot Israel (2024). Asthma Biologics: Lung Function, Steroid-Dependence, and Exacerbations. Immunology and allergy clinics of North America, 693-708. https://doi.org/10.1016/j.iac.2024.08.002 PMID: 39389718",
                    "39389718"
                ],
                [
                    "Aleksandra Plavsic, Branka Bonaci-Nikolic, Branislava Milenkovic, Rada Miskovic, Natasa Kusic, Milan Dimitrijevic, Snezana Arandjelovic, Katarina Milosevic, Ivana Buha, Vesna Tomic Spiric (2024). Asthma Inflammatory Phenotypes: How Can We Distinguish Them? Journal of clinical medicine. https://doi.org/10.3390/jcm13020526 PMID: 38256660",
                    "38256660"
                ],
                [
                    "P Abigail Alvarado-Vazquez, Erika Mendez-Enriquez, Maya Salomonsson, Peter Kopac, Ana Koren, Urska Bidovec-Stojkovic, Sabina Škrgat, Oscar E Simonson, Valentyna Yasinska, Sven-Erik Dahlén, Gunnar Pejler, Christer Janson, Peter Korosec, Andrei Malinovschi, Jenny Hallgren (2024). Targeting of the IL-5 pathway in severe asthma reduces mast cell progenitors. The Journal of allergy and clinical immunology. https://doi.org/10.1016/j.jaci.2024.10.025 PMID: 39521285",
                    "39521285"
                ],
                [
                    "Julia U Holle, Frank Moosig (2024). [Update on treatment of ANCA-associated vasculitis]. Zeitschrift fur Rheumatologie, 787-799. https://doi.org/10.1007/s00393-024-01548-1 PMID: 39196354",
                    "39196354"
                ],
                [
                    "Susana Rojo-Tolosa, José Antonio Sánchez-Martínez, Alberto Caballero-Vázquez, Laura Elena Pineda-Lancheros, María Victoria González-Gutiérrez, Cristina Pérez-Ramírez, Alberto Jiménez-Morales, Concepción Morales-García (2024). SingleNucleotide Polymorphisms as Biomarkers of Mepolizumab and Benralizumab Treatment Response in Severe Eosinophilic Asthma. International journal of molecular sciences. https://doi.org/10.3390/ijms25158139 PMID: 39125709",
                    "39125709"
                ],
                [
                    "Christian Pagnoux, Alvise Berti (2023). Advances in the pharmacotherapeutic management of eosinophilic granulomatosis with polyangiitis. Expert opinion on pharmacotherapy, 1269-1281. https://doi.org/10.1080/14656566.2023.2216379 PMID: 37204027",
                    "37204027"
                ]
            ]
        ]
    ]
}