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                    "Satvik Mareedu, Nadezhda Fefelova, Cristi L Galindo, Goutham Prakash, Risa Mukai, Junichi Sadoshima, Lai-Hua Xie, Gopal J Babu (2024). Improved mitochondrial function in the hearts of sarcolipin-deficient dystrophin and utrophin double-knockout mice. JCI insight. PMID: 38564291",
                    "38564291"
                ],
                [
                    "Mario Van Poucke, Liesbet Ledeganck, Ling T Guo, G Diane Shelton, Sofie F M Bhatti, Ine Cornelis, Luc Peelman (2024). Exonisation of an intronic L1 element in the dystrophin gene associated with X-linked muscular dystrophy in a Border Collie dog. Animal genetics, 733-743. https://doi.org/10.1111/age.13470 PMID: 39152696",
                    "39152696"
                ],
                [
                    "Glen B Banks, Jeffrey S Chamberlain, Guy L Odom (2020). Microutrophin expression in dystrophic mice displays myofiber type differences in therapeutic effects. PLoS genetics, e1009179. https://doi.org/10.1371/journal.pgen.1009179 PMID: 33175853",
                    "33175853"
                ],
                [
                    "Elizabeth M Gibbs, Florian Barthélémy, Emilie D Douine, Natalie C Hardiman, Perry B Shieh, Negar Khanlou, Rachelle H Crosbie, Stanley F Nelson, M Carrie Miceli (2019). Large in-frame 5' deletions in DMD associated with mild Duchenne muscular dystrophy: Two case reports and a review of the literature. Neuromuscular disorders : NMD, 863-873. https://doi.org/10.1016/j.nmd.2019.09.009 PMID: 31672265",
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                [
                    "Michelle S Parvatiyar, Alexandra J Brownstein, Rosemeire M Kanashiro-Takeuchi, Judd R Collado, Karissa M Dieseldorff Jones, Jay Gopal, Katherine G Hammond, Jamie L Marshall, Abel Ferrel, Aaron M Beedle, Jeffrey S Chamberlain, Jose Renato Pinto, Rachelle H Crosbie (2019). Stabilization of the cardiac sarcolemma by sarcospan rescues DMD-associated cardiomyopathy. JCI insight. PMID: 31039133",
                    "31039133"
                ],
                [
                    "Antoine Boulanger Piette, Dounia Hamoudi, Laetitia Marcadet, Frédérique Kyomi Labelle, Rares Ovidiu David, Sabrina Bossé, Anteneh Argaw, Jérôme Frenette (2018). Utrophin haploinsufficiency does not worsen the functional performance, resistance to eccentric contractions and force production of dystrophic mice. PloS one, e0198408. https://doi.org/10.1371/journal.pone.0198408 PMID: 29879154",
                    "29879154"
                ],
                [
                    "Cinzia Pisani, Georgios Strimpakos, Francesca Gabanella, Maria Grazia Di Certo, Annalisa Onori, Cinzia Severini, Siro Luvisetto, Stefano Farioli-Vecchioli, Irene Carrozzo, Antonio Esposito, Tamara Canu, Elisabetta Mattei, Nicoletta Corbi, Claudio Passananti (2018). Utrophin up-regulation by artificial transcription factors induces muscle rescue and impacts the neuromuscular junction in mdx mice. Biochimica et biophysica acta. Molecular basis of disease, 1172-1182. https://doi.org/10.1016/j.bbadis.2018.01.030 PMID: 29408646",
                    "29408646"
                ],
                [
                    "Eun-Bee Cho, Wonjin Yoo, Sungjoo Kim Yoon, Jong-Bok Yoon (2018). β-dystroglycan is regulated by a balance between WWP1-mediated degradation and protection from WWP1 by dystrophin and utrophin. Biochimica et biophysica acta. Molecular basis of disease, 2199-2213. https://doi.org/10.1016/j.bbadis.2018.04.001 PMID: 29635000",
                    "29635000"
                ],
                [
                    "Suriyan Ponnusamy, Ryan D Sullivan, Dahui You, Nadeem Zafar, Chuan He Yang, Thirumagal Thiyagarajan, Daniel L Johnson, Maron L Barrett, Nikki J Koehler, Mayra Star, Erin J Stephenson, Dave Bridges, Stephania A Cormier, Lawrence M Pfeffer, Ramesh Narayanan (2017). Androgen receptor agonists increase lean mass, improve cardiopulmonary functions and extend survival in preclinical models of Duchenne muscular dystrophy. Human molecular genetics, 2526-2540. https://doi.org/10.1093/hmg/ddx150 PMID: 28453658",
                    "28453658"
                ],
                [
                    "Jill A Rafael-Fortney, Jessica A Chadwick, Subha V Raman (2016). Duchenne Muscular Dystrophy Mice and Men: Can Understanding a Genetic Cardiomyopathy Inform Treatment of Other Myocardial Diseases? Circulation research, 1059-61. https://doi.org/10.1161/CIRCRESAHA.116.308402 PMID: 27034274",
                    "27034274"
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                "dystrophin",
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                [
                    "Roberta Marozzo, Valentina Pegoraro, Corrado Angelini (2020). MiRNAs, Myostatin, and Muscle MRI Imaging as Biomarkers of Clinical Features in Becker Muscular Dystrophy. Diagnostics (Basel, Switzerland). https://doi.org/10.3390/diagnostics10090713 PMID: 32961888",
                    "32961888"
                ],
                [
                    "Saleh Omairi, Kwan-Leong Hau, Henry Collins-Hooper, Charlotte Scott, Sakthivel Vaiyapuri, Silvia Torelli, Federica Montanaro, Antonios Matsakas, Ketan Patel (2019). Regulation of the dystrophin-associated glycoprotein complex composition by the metabolic properties of muscle fibres. Scientific reports, 2770. https://doi.org/10.1038/s41598-019-39532-4 PMID: 30808964",
                    "30808964"
                ],
                [
                    "Dong-Ho Bak, Mi Ji Choi, Esther Lee, Tae-Rin Kwon, Jong Hwan Kim, Sang-Hyun Nam, Kyoung-Yun Kim, Seung Won Ahn, Seog-Kyun Mun, Jungtae Na, Beom Joon Kim (2019). A comparison study of prabotulinumtoxinA vs onabotulinumtoxinA in myostatin-deficient mice with muscle hypertrophy. Basic & clinical pharmacology & toxicology, 491-499. https://doi.org/10.1111/bcpt.13151 PMID: 30326173",
                    "30326173"
                ],
                [
                    "Kenneth M Estrellas, Liam Chung, Lindsay A Cheu, Kaitlyn Sadtler, Shoumyo Majumdar, Jyothi Mula, Matthew T Wolf, Jennifer H Elisseeff, Kathryn R Wagner (2018). Biological scaffold-mediated delivery of myostatin inhibitor promotes a regenerative immune response in an animal model of Duchenne muscular dystrophy. The Journal of biological chemistry, 15594-15605. https://doi.org/10.1074/jbc.RA118.004417 PMID: 30139748",
                    "30139748"
                ],
                [
                    "Joe N Kornegay, Daniel J Bogan, Janet R Bogan, Jennifer L Dow, Jiahui Wang, Zheng Fan, Naili Liu, Leigh C Warsing, Robert W Grange, Mihye Ahn, Cynthia J Balog-Alvarez, Steven W Cotten, Monte S Willis, Candice Brinkmeyer-Langford, Hongtu Zhu, Joe Palandra, Carl A Morris, Martin A Styner, Kathryn R Wagner (2016). Dystrophin-deficient dogs with reduced myostatin have unequal muscle growth and greater joint contractures. Skeletal muscle, 14. https://doi.org/10.1186/s13395-016-0085-7 PMID: 27047655",
                    "27047655"
                ],
                [
                    "Jerry R Mendell, Zarife Sahenk, Vinod Malik, Ana M Gomez, Kevin M Flanigan, Linda P Lowes, Lindsay N Alfano, Katherine Berry, Eric Meadows, Sarah Lewis, Lyndsey Braun, Kim Shontz, Maria Rouhana, Kelly Reed Clark, Xiomara Q Rosales, Samiah Al-Zaidy, Alessandra Govoni, Louise R Rodino-Klapac, Mark J Hogan, Brian K Kaspar (2015). A phase 1/2a follistatin gene therapy trial for becker muscular dystrophy. Molecular therapy : the journal of the American Society of Gene Therapy, 192-201. https://doi.org/10.1038/mt.2014.200 PMID: 25322757",
                    "25322757"
                ],
                [
                    "Ngoc B Lu-Nguyen, Susan A Jarmin, Amer F Saleh, Linda Popplewell, Michael J Gait, George Dickson (2015). Combination Antisense Treatment for Destructive Exon Skipping of Myostatin and Open Reading Frame Rescue of Dystrophin in Neonatal mdx Mice. Molecular therapy : the journal of the American Society of Gene Therapy, 1341-1348. https://doi.org/10.1038/mt.2015.88 PMID: 25959011",
                    "25959011"
                ],
                [
                    "N V Ermolova, L Martinez, S A Vetrone, M C Jordan, K P Roos, H L Sweeney, M J Spencer (2014). Long-term administration of the TNF blocking drug Remicade (cV1q) to mdx mice reduces skeletal and cardiac muscle fibrosis, but negatively impacts cardiac function. Neuromuscular disorders : NMD, 583-95. PMID: 24844454",
                    "24844454"
                ],
                [
                    "Burcu Bestas, Graham McClorey, Ulf Tedebark, Pedro M D Moreno, Thomas C Roberts, Suzan M Hammond, C I Edvard Smith, Matthew J A Wood, Samir El Andaloussi (2014). Design and application of bispecific splice-switching oligonucleotides. Nucleic acid therapeutics, 13-24. https://doi.org/10.1089/nat.2013.0462 PMID: 24506779",
                    "24506779"
                ],
                [
                    "Tony Huynh, Kitipong Uaesoontrachoon, James L Quinn, Kathleen S Tatem, Christopher R Heier, Jack H Van Der Meulen, Qing Yu, Mark Harris, Christopher J Nolan, Guy Haegeman, Miranda D Grounds, Kanneboyina Nagaraju (2013). Selective modulation through the glucocorticoid receptor ameliorates muscle pathology in mdx mice. The Journal of pathology, 223-35. https://doi.org/10.1002/path.4231 PMID: 23794417",
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                    "25322757"
                ],
                [
                    "Joe V Chakkalakal, Jennifer Thompson, Robin J Parks, Bernard J Jasmin (2005). Molecular, cellular, and pharmacological therapies for Duchenne/Becker muscular dystrophies. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 880-91. https://doi.org/10.1096/fj.04-1956rev PMID: 15923398",
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                    "Alexis Osseni, Aymeric Ravel-Chapuis, Edwige Belotti, Isabella Scionti, Yann-Gaël Gangloff, Vincent Moncollin, Laetitia Mazelin, Remi Mounier, Pascal Leblanc, Bernard J Jasmin, Laurent Schaeffer (2022). Pharmacological inhibition of HDAC6 improves muscle phenotypes in dystrophin-deficient mice by downregulating TGF-β via Smad3 acetylation. Nature communications, 7108. https://doi.org/10.1038/s41467-022-34831-3 PMID: 36402791",
                    "36402791"
                ],
                [
                    "Claire Yuan, Ashwin Arora, Anthony M Garofalo, Robert W Grange (2021). Potential cross-talk between muscle and tendon in Duchenne muscular dystrophy. Connective tissue research, 40-52. https://doi.org/10.1080/03008207.2020.1810247 PMID: 32867551",
                    "32867551"
                ],
                [
                    "Benjamin R Pryce, Cédrik Labrèche, Dounia Hamoudi, John Abou-Hamad, Khalid N Al-Zahrani, Jonathan J Hodgins, Antoine Boulanger-Piette, Sabrina Bossé, Cindy Balog-Alvarez, Jérôme Frénette, Michele Ardolino, Joe N Kornegay, Luc A Sabourin (2021). Muscle-specific deletion of SLK/Stk2 enhances p38 activity and myogenesis in mdx mice. Biochimica et biophysica acta. Molecular cell research, 118917. https://doi.org/10.1016/j.bbamcr.2020.118917 PMID: 33259860",
                    "33259860"
                ],
                [
                    "Luca Caputo, Alice Granados, Jessica Lenzi, Alessandro Rosa, Slimane Ait-Si-Ali, Pier Lorenzo Puri, Sonia Albini (2020). Acute conversion of patient-derived Duchenne muscular dystrophy iPSC into myotubes reveals constitutive and inducible over-activation of TGFβ-dependent pro-fibrotic signaling. Skeletal muscle, 13. https://doi.org/10.1186/s13395-020-00224-7 PMID: 32359374",
                    "32359374"
                ],
                [
                    "Irina Kramerova, Chino Kumagai-Cresse, Natalia Ermolova, Ekaterina Mokhonova, Masha Marinov, Joana Capote, Diana Becerra, Mattia Quattrocelli, Rachelle H Crosbie, Ellen Welch, Elizabeth M McNally, Melissa J Spencer (2019). Spp1 (osteopontin) promotes TGFβ processing in fibroblasts of dystrophin-deficient muscles through matrix metalloproteinases. Human molecular genetics, 3431-3442. https://doi.org/10.1093/hmg/ddz181 PMID: 31411676",
                    "31411676"
                ],
                [
                    "Ariel Bier, Peter Berenstein, Noam Kronfeld, Daria Morgoulis, Amotz Ziv-Av, Hodaya Goldstein, Gila Kazimirsky, Simona Cazacu, Rinat Meir, Rachela Popovtzer, Amir Dori, Chaya Brodie (2018). Placenta-derived mesenchymal stromal cells and their exosomes exert therapeutic effects in Duchenne muscular dystrophy. Biomaterials, 67-78. https://doi.org/10.1016/j.biomaterials.2018.04.055 PMID: 29783118",
                    "29783118"
                ],
                [
                    "Samara Camaçari de Carvalho, Cintia Yuri Matsumura, Humberto Santo Neto, Maria Julia Marques (2018). Identification of plasma interleukins as biomarkers for deflazacort and omega-3 based Duchenne muscular dystrophy therapy. Cytokine, 55-61. https://doi.org/10.1016/j.cyto.2017.12.006 PMID: 29276972",
                    "29276972"
                ],
                [
                    "Robert B Weiss, Veronica J Vieland, Diane M Dunn, Yuuki Kaminoh, Kevin M Flanigan,   (2018). Long-range genomic regulators of THBS1 and LTBP4 modify disease severity in duchenne muscular dystrophy. Annals of neurology, 234-245. https://doi.org/10.1002/ana.25283 PMID: 30014611",
                    "30014611"
                ],
                [
                    "Michael R Hicks, Julia Hiserodt, Katrina Paras, Wakana Fujiwara, Ascia Eskin, Majib Jan, Haibin Xi, Courtney S Young, Denis Evseenko, Stanley F Nelson, Melissa J Spencer, Ben Van Handel, April D Pyle (2018). ERBB3 and NGFR mark a distinct skeletal muscle progenitor cell in human development and hPSCs. Nature cell biology, 46-57. https://doi.org/10.1038/s41556-017-0010-2 PMID: 29255171",
                    "29255171"
                ],
                [
                    "Mattia Quattrocelli, Joanna Capote, Joyce C Ohiri, James L Warner, Andy H Vo, Judy U Earley, Michele Hadhazy, Alexis R Demonbreun, Melissa J Spencer, Elizabeth M McNally (2017). Genetic modifiers of muscular dystrophy act on sarcolemmal resealing and recovery from injury. PLoS genetics, e1007070. https://doi.org/10.1371/journal.pgen.1007070 PMID: 29065150",
                    "29065150"
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                [
                    "D D Tan, Y D Liu, Y B Fan, C J Wei, D Y Song, H P Yang, H Pan, W L Cui, S S Mao, X P Xu, X L Yu, B Cui, H Xiong (2023). [Clinical and genetic characteristics of 9 rare cases with coexistence of dual genetic diagnoses]. Zhonghua er ke za zhi = Chinese journal of pediatrics, 345-350. https://doi.org/10.3760/cma.j.cn112140-20220922-00827 PMID: 37011981",
                    "37011981"
                ],
                [
                    "Ha Rim Shin, Eun-Ji Ko, Yun-Jeong Kang, Hak-Sun Yu, Mee Sun Ock, Hee-Jae Cha (2023). Effect of parasitic infection on muscular function of dystrophin gene (Dmd) deficient mouse. Genes & genomics, 183-190. https://doi.org/10.1007/s13258-022-01355-5 PMID: 36571712",
                    "36571712"
                ],
                [
                    "Abdulrahman Jama, Abdullah A Alshudukhi, Steve Burke, Lixin Dong, John Karanja Kamau, Andrew Alvin Voss, Hongmei Ren (2023). Lipin1 plays complementary roles in myofibre stability and regeneration in dystrophic muscles. The Journal of physiology, 961-978. https://doi.org/10.1113/JP284085 PMID: 36715084",
                    "36715084"
                ],
                [
                    "Fawzy A Saad, Gabriele Siciliano, Corrado Angelini (2023). Advances in Dystrophinopathy Diagnosis and Therapy. Biomolecules. https://doi.org/10.3390/biom13091319 PMID: 37759719",
                    "37759719"
                ],
                [
                    "Judith van Deutekom, Chantal Beekman, Suzanne Bijl, Sieto Bosgra, Rani van den Eijnde, Dennis Franken, Bas Groenendaal, Bouchra Harquouli, Anneke Janson, Paul Koevoets, Melissa Mulder, Daan Muilwijk, Galyna Peterburgska, Bianca Querido, Janwillem Testerink, Ruurd Verheul, Peter de Visser, Rudie Weij, Annemieke Aartsma-Rus, Jukka Puoliväli, Timo Bragge, Charles O'Neill, Nicole A Datson (2023). Next Generation Exon 51 Skipping Antisense Oligonucleotides for Duchenne Muscular Dystrophy. Nucleic acid therapeutics, 193-208. https://doi.org/10.1089/nat.2022.0063 PMID: 37036788",
                    "37036788"
                ],
                [
                    "Fei Peng, Huayan Xu, Yu Song, Ke Xu, Shuhao Li, Xiaotang Cai, Yingkun Guo, Lianggeng Gong (2022). Utilization of T1-Mapping for the pelvic and thigh muscles in Duchenne Muscular Dystrophy: a quantitative biomarker for disease involvement and correlation with clinical assessments. BMC musculoskeletal disorders, 681. https://doi.org/10.1186/s12891-022-05640-y PMID: 35842609",
                    "35842609"
                ],
                [
                    "Marianela Schiava, Rachel Amos, Henriette VanRuiten, Michael P McDermott, Williams B Martens, Stephanie Gregory, Anna Mayhew, Elaine McColl, Rabi Tawil, Tracey Willis, Kate Bushby, Robert C Griggs, Michela Guglieri,   (2021). Clinical and Genetic Characteristics in Young, Glucocorticoid-Naive Boys With Duchenne Muscular Dystrophy. Neurology. https://doi.org/10.1212/WNL.0000000000013122 PMID: 34857536",
                    "34857536"
                ],
                [
                    "Ranjan K Singh (2021). Late-Onset Dystrophinopathy. Cureus, e20531. https://doi.org/10.7759/cureus.20531 PMID: 35070564",
                    "35070564"
                ],
                [
                    "Jerry R Mendell, Zarife Sahenk, Kelly Lehman, Carrie Nease, Linda P Lowes, Natalie F Miller, Megan A Iammarino, Lindsay N Alfano, Amanda Nicholl, Samiah Al-Zaidy, Sarah Lewis, Kathleen Church, Richard Shell, Linda H Cripe, Rachael A Potter, Danielle A Griffin, Eric Pozsgai, Ashish Dugar, Mark Hogan, Louise R Rodino-Klapac (2020). Assessment of Systemic Delivery of rAAVrh74.MHCK7.micro-dystrophin in Children With Duchenne Muscular Dystrophy: A Nonrandomized Controlled Trial. JAMA neurology, 1122-1131. https://doi.org/10.1001/jamaneurol.2020.1484 PMID: 32539076",
                    "32539076"
                ],
                [
                    "Yuko Nakamura, Yoshiaki Saito, Norika Kubota, Wataru Matsumura, Chika Hosoda, Akiko Tamasaki-Kondo, Yoko Nishimura, Yoshihide Sunada, Masuyuki Fukada, Takako Ohno, Yoshihiro Maegaki, Masafumi Matsuo, Yasuko Tokita (2018). Identification of sleep hypoventilation in young individuals with Becker muscular dystrophy: A pilot study. Brain & development, 537-543. https://doi.org/10.1016/j.braindev.2018.02.012 PMID: 29526517",
                    "29526517"
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        [
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                [
                    "Swathy Krishna, Arden B Piepho, Dana M Lake, Laurel R Cumby, Kaelyn K Lortz, Jeovanna Lowe, Jeffrey S Chamberlain, Jill A Rafael-Fortney (2024). Gene therapy delivered micro-dystrophins co-localize with transgenic utrophin in dystrophic skeletal muscle fibers. Neuromuscular disorders : NMD, 1-5. https://doi.org/10.1016/j.nmd.2024.01.004 PMID: 38301403",
                    "38301403"
                ],
                [
                    "Sylwia Szwec, Zuzanna Kapłucha, Jeffrey S Chamberlain, Patryk Konieczny (2023). Dystrophin- and Utrophin-Based Therapeutic Approaches for Treatment of Duchenne Muscular Dystrophy: A Comparative Review. BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy. https://doi.org/10.1007/s40259-023-00632-3 PMID: 37917377",
                    "37917377"
                ],
                [
                    "Dylan Moutachi, Mégane Lemaitre, Clément Delacroix, Onnik Agbulut, Denis Furling, Arnaud Ferry (2023). Valproic acid reduces muscle susceptibility to contraction-induced functional loss but increases weakness in two murine models of Duchenne muscular dystrophy. Clinical and experimental pharmacology & physiology, 749-756. https://doi.org/10.1111/1440-1681.13804 PMID: 37381823",
                    "37381823"
                ],
                [
                    "Britt Hanson, Sofia Stenler, Nina Ahlskog, Katarzyna Chwalenia, Nenad Svrzikapa, Anna M L Coenen-Stass, Marc S Weinberg, Matthew J A Wood, Thomas C Roberts (2022). Non-uniform dystrophin re-expression after CRISPR-mediated exon excision in the dystrophin/utrophin double-knockout mouse model of DMD. Molecular therapy. Nucleic acids, 379-397. https://doi.org/10.1016/j.omtn.2022.10.010 PMID: 36420212",
                    "36420212"
                ],
                [
                    "Angelina M Georgieva, Xinyue Guo, Marek Bartkuhn, Stefan Günther, Carsten Künne, Christian Smolka, Ann Atzberger, Ulrich Gärtner, Kamel Mamchaoui, Eva Bober, Yonggang Zhou, Xuejun Yuan, Thomas Braun (2022). Inactivation of Sirt6 ameliorates muscular dystrophy in mdx mice by releasing suppression of utrophin expression. Nature communications, 4184. https://doi.org/10.1038/s41467-022-31798-z PMID: 35859073",
                    "35859073"
                ],
                [
                    "Angus Lindsay, Bailey Kemp, Alexie A Larson, Cory W Baumann, Preston M McCourt, John Holm, Peter Karachunski, Dawn A Lowe, James M Ervasti (2021). Tetrahydrobiopterin synthesis and metabolism is impaired in dystrophin-deficient mdx mice and humans. Acta physiologica (Oxford, England), e13627. https://doi.org/10.1111/apha.13627 PMID: 33580591",
                    "33580591"
                ],
                [
                    "Kate J Sadler, Paul A Della Gatta, Timur Naim, Marita A Wallace, Albert Lee, Thiri Zaw, Angus Lindsay, Roger S Chung, Luca Bello, Elena Pegoraro, Séverine Lamon, Gordon S Lynch, Aaron P Russell (2021). Striated muscle activator of Rho signalling (STARS) overexpression in the mdx mouse enhances muscle functional capacity and regulates the actin cytoskeleton and oxidative phosphorylation pathways. Experimental physiology, 1597-1611. https://doi.org/10.1113/EP089253 PMID: 33963617",
                    "33963617"
                ],
                [
                    "Patricia Soblechero-Martín, Andrea López-Martínez, Laura de la Puente-Ovejero, Ainara Vallejo-Illarramendi, Virginia Arechavala-Gomeza (2021). Utrophin modulator drugs as potential therapies for Duchenne and Becker muscular dystrophies. Neuropathology and applied neurobiology, 711-723. https://doi.org/10.1111/nan.12735 PMID: 33999469",
                    "33999469"
                ],
                [
                    "Paul T Martin, Deborah A Zygmunt, Anna Ashbrook, Sonia Hamilton, Davin Packer, Sharla M Birch, Amanda K Bettis, Cynthia J Balog-Alvarez, Lee-Jae Guo, Peter P Nghiem, Joe N Kornegay (2021). Short-term treatment of golden retriever muscular dystrophy (GRMD) dogs with rAAVrh74.MHCK7.GALGT2 induces muscle glycosylation and utrophin expression but has no significant effect on muscle strength. PloS one, e0248721. https://doi.org/10.1371/journal.pone.0248721 PMID: 33770101",
                    "33770101"
                ],
                [
                    "Craig M McDonald, Israel Ramirez-Sanchez, Björn Oskarsson, Nanette Joyce, Candace Aguilar, Alina Nicorici, Jonathan Dayan, Erica Goude, R Ted Abresch, Francisco Villarreal, Guillermo Ceballos, Guy Perkins, Sundeep Dugar, George Schreiner, Erik K Henricson (2021). (-)-Epicatechin induces mitochondrial biogenesis and markers of muscle regeneration in adults with Becker muscular dystrophy. Muscle & nerve, 239-249. https://doi.org/10.1002/mus.27108 PMID: 33125736",
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                    "Ha Rim Shin, Eun-Ji Ko, Yun-Jeong Kang, Hak-Sun Yu, Mee Sun Ock, Hee-Jae Cha (2023). Effect of parasitic infection on muscular function of dystrophin gene (Dmd) deficient mouse. Genes & genomics, 183-190. https://doi.org/10.1007/s13258-022-01355-5 PMID: 36571712",
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                ],
                [
                    "Corinna Preuße, Arpad von Moers, Heike Kölbel, Debora Pehl, Hans-Hilmar Goebel, Ulrike Schara, Werner Stenzel (2019). Inflammation-induced fibrosis in skeletal muscle of female carriers of Duchenne muscular dystrophy. Neuromuscular disorders : NMD, 487-496. https://doi.org/10.1016/j.nmd.2019.05.003 PMID: 31326192",
                    "31326192"
                ]
            ]
        ],
        [
            [
                "utrophin",
                "myostatin"
            ],
            1.0635987,
            [
                [
                    "Craig M McDonald, Israel Ramirez-Sanchez, Björn Oskarsson, Nanette Joyce, Candace Aguilar, Alina Nicorici, Jonathan Dayan, Erica Goude, R Ted Abresch, Francisco Villarreal, Guillermo Ceballos, Guy Perkins, Sundeep Dugar, George Schreiner, Erik K Henricson (2021). (-)-Epicatechin induces mitochondrial biogenesis and markers of muscle regeneration in adults with Becker muscular dystrophy. Muscle & nerve, 239-249. https://doi.org/10.1002/mus.27108 PMID: 33125736",
                    "33125736"
                ],
                [
                    "Theodora Markati, Liesbeth De Waele, Urlike Schara-Schmidt, Laurent Servais (2021). Lessons Learned from Discontinued Clinical Developments in Duchenne Muscular Dystrophy. Frontiers in pharmacology, 735912. https://doi.org/10.3389/fphar.2021.735912 PMID: 34790118",
                    "34790118"
                ],
                [
                    "Perry B Shieh (2018). Emerging Strategies in the Treatment of Duchenne Muscular Dystrophy. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 840-848. https://doi.org/10.1007/s13311-018-00687-z PMID: 30414046",
                    "30414046"
                ],
                [
                    "Megan Crone, Jean K Mah (2018). Current and Emerging Therapies for Duchenne Muscular Dystrophy. Current treatment options in neurology, 31. https://doi.org/10.1007/s11940-018-0513-6 PMID: 29936551",
                    "29936551"
                ],
                [
                    "Justin R Fallon, Elizabeth M McNally (2018). Non-Glycanated Biglycan and LTBP4: Leveraging the extracellular matrix for Duchenne Muscular Dystrophy therapeutics. Matrix biology : journal of the International Society for Matrix Biology, 616-627. https://doi.org/10.1016/j.matbio.2018.02.016 PMID: 29481844",
                    "29481844"
                ],
                [
                    "Urs T Ruegg (2013). Pharmacological prospects in the treatment of Duchenne muscular dystrophy. Current opinion in neurology, 577-84. https://doi.org/10.1097/WCO.0b013e328364fbaf PMID: 23995279",
                    "23995279"
                ],
                [
                    "Peter P Nghiem, Eric P Hoffman, Priya Mittal, Kristy J Brown, Scott J Schatzberg, Svetlana Ghimbovschi, Zuyi Wang, Joe N Kornegay (2013). Sparing of the dystrophin-deficient cranial sartorius muscle is associated with classical and novel hypertrophy pathways in GRMD dogs. The American journal of pathology, 1411-24. PMID: 24160322",
                    "24160322"
                ],
                [
                    "Vinod Malik, Louise R Rodino-Klapac, Jerry R Mendell (2012). Emerging drugs for Duchenne muscular dystrophy. Expert opinion on emerging drugs, 261-77. https://doi.org/10.1517/14728214.2012.691965 PMID: 22632414",
                    "22632414"
                ],
                [
                    "Maria de los Angeles Beytía, Julia Vry, Janbernd Kirschner (2012). Drug treatment of Duchenne muscular dystrophy: available evidence and perspectives. Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology, 4-8. PMID: 22655510",
                    "22655510"
                ],
                [
                    "Robin N Michel, Eva R Chin, Joe V Chakkalakal, Joe K Eibl, Bernard J Jasmin (2007). Ca2+/calmodulin-based signalling in the regulation of the muscle fibre phenotype and its therapeutic potential via modulation of utrophin A and myostatin expression. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 921-9. https://doi.org/10.1139/H07-093 PMID: 18059617",
                    "18059617"
                ]
            ]
        ],
        [
            [
                "dystrophin",
                "TGFB1"
            ],
            0.7260498999999999,
            [
                [
                    "Catherine A Bellissimo, Shivam Gandhi, Laura N Castellani, Mayoorey Murugathasan, Luca J Delfinis, Arshdeep Thuhan, Madison C Garibotti, Yeji Seo, Irena A Rebalka, Henry H Hsu, Gary Sweeney, Thomas J Hawke, Ali A Abdul-Sater, Christopher G R Perry (2024). The slow-release adiponectin analog ALY688-SR modifies early-stage disease development in the D2.mdx mouse model of Duchenne muscular dystrophy. American journal of physiology. Cell physiology, C1011-C1026. https://doi.org/10.1152/ajpcell.00638.2023 PMID: 38145301",
                    "38145301"
                ],
                [
                    "Kadalraja Raghavan, Vidyasagar Devaprasad Dedeepiya, Subramaniam Srinivasan, Subramanian Pushkala, Sudhakar S Bharatidasan, Nobunao Ikewaki, Masaru Iwasaki, Rajappa Senthilkumar, Senthilkumar Preethy, Samuel J K Abraham (2023). Beneficial immune-modulatory effects of the N-163 strain of Aureobasidium pullulans-produced 1,3-1,6 Beta glucans in Duchenne muscular dystrophy: Results of an open-label, prospective, exploratory case-control clinical study. IBRO neuroscience reports, 90-99. https://doi.org/10.1016/j.ibneur.2023.06.007 PMID: 38053632",
                    "38053632"
                ],
                [
                    "Hironobu Takahashi, Kaho Ishiyama, Naoya Takeda, Tatsuya Shimizu (2023). Nutrient Rescue of Early Maturing and Deteriorating Satellite Cell-Derived Engineered Muscle Tissue. Tissue engineering. Part A. https://doi.org/10.1089/ten.TEA.2023.0007 PMID: 37694582",
                    "37694582"
                ],
                [
                    "Marcelo Dos Santos Voltani Lorena, Estela Kato Dos Santos, Renato Ferretti, G A Nagana Gowda, Guy L Odom, Jeffrey S Chamberlain, Cintia Yuri Matsumura (2023). Biomarkers for Duchenne muscular dystrophy progression: impact of age in the mdx tongue spared muscle. Skeletal muscle, 16. https://doi.org/10.1186/s13395-023-00325-z PMID: 37705069",
                    "37705069"
                ],
                [
                    "Marcelo Dos Santos Voltani Lorena, Estela Kato Santos, Renato Ferretti, G A Nagana Gowda, Guy L Odom, Jeffrey S Chamberlain, Cintia Yuri Matsumura (2023). Biomarkers for Duchenne muscular dystrophy progression: impact of age in the mdx tongue spared muscle. Research square. https://doi.org/10.21203/rs.3.rs-3038923/v1 PMID: 37398370",
                    "37398370"
                ],
                [
                    "Małgorzata Myszka, Olga Mucha, Paulina Podkalicka, Urszula Waśniowska, Józef Dulak, Agnieszka Łoboda (2023). Sodium hydrosulfide moderately alleviates the hallmark symptoms of Duchenne muscular dystrophy in mdx mice. European journal of pharmacology, 175928. https://doi.org/10.1016/j.ejphar.2023.175928 PMID: 37507045",
                    "37507045"
                ],
                [
                    "Ha Rim Shin, Eun-Ji Ko, Yun-Jeong Kang, Hak-Sun Yu, Mee Sun Ock, Hee-Jae Cha (2023). Effect of parasitic infection on muscular function of dystrophin gene (Dmd) deficient mouse. Genes & genomics, 183-190. https://doi.org/10.1007/s13258-022-01355-5 PMID: 36571712",
                    "36571712"
                ],
                [
                    "Alexis Osseni, Aymeric Ravel-Chapuis, Edwige Belotti, Isabella Scionti, Yann-Gaël Gangloff, Vincent Moncollin, Laetitia Mazelin, Remi Mounier, Pascal Leblanc, Bernard J Jasmin, Laurent Schaeffer (2022). Pharmacological inhibition of HDAC6 improves muscle phenotypes in dystrophin-deficient mice by downregulating TGF-β via Smad3 acetylation. Nature communications, 7108. https://doi.org/10.1038/s41467-022-34831-3 PMID: 36402791",
                    "36402791"
                ],
                [
                    "Brian L Lin, Joseph Y Shin, William Pd Jeffreys, Nadan Wang, Clarisse A Lukban, Megan C Moorer, Esteban Velarde, Olivia A Hanselman, Seoyoung Kwon, Suraj Kannan, Ryan C Riddle, Christopher W Ward, Steven S Pullen, Antonio Filareto, David A Kass (2022). Pharmacological TRPC6 inhibition improves survival and muscle function in mice with Duchenne muscular dystrophy. JCI insight. PMID: 36099033",
                    "36099033"
                ],
                [
                    "Maria Laura Jorge Micheletto, Tulio de Almeida Hermes, Bruno Machado Bertassoli, Giuliana Petri, Matheus Moreira Perez, Fernando Luiz Affonso Fonseca, Alzira Alves de Siqueira Carvalho, David Feder (2021). Ixazomib, an oral proteasome inhibitor, exhibits potential effect in dystrophin-deficient mdx mice. International journal of experimental pathology, 11-21. https://doi.org/10.1111/iep.12383 PMID: 33296126",
                    "33296126"
                ]
            ]
        ],
        [
            [
                "utrophin",
                "TGFB1"
            ],
            0.7260498999999999,
            [
                [
                    "Brian L Lin, Joseph Y Shin, William Pd Jeffreys, Nadan Wang, Clarisse A Lukban, Megan C Moorer, Esteban Velarde, Olivia A Hanselman, Seoyoung Kwon, Suraj Kannan, Ryan C Riddle, Christopher W Ward, Steven S Pullen, Antonio Filareto, David A Kass (2022). Pharmacological TRPC6 inhibition improves survival and muscle function in mice with Duchenne muscular dystrophy. JCI insight. PMID: 36099033",
                    "36099033"
                ],
                [
                    "Maria Laura Jorge Micheletto, Tulio de Almeida Hermes, Bruno Machado Bertassoli, Giuliana Petri, Matheus Moreira Perez, Fernando Luiz Affonso Fonseca, Alzira Alves de Siqueira Carvalho, David Feder (2021). Ixazomib, an oral proteasome inhibitor, exhibits potential effect in dystrophin-deficient mdx mice. International journal of experimental pathology, 11-21. https://doi.org/10.1111/iep.12383 PMID: 33296126",
                    "33296126"
                ],
                [
                    "Benjamin R Pryce, Cédrik Labrèche, Dounia Hamoudi, John Abou-Hamad, Khalid N Al-Zahrani, Jonathan J Hodgins, Antoine Boulanger-Piette, Sabrina Bossé, Cindy Balog-Alvarez, Jérôme Frénette, Michele Ardolino, Joe N Kornegay, Luc A Sabourin (2021). Muscle-specific deletion of SLK/Stk2 enhances p38 activity and myogenesis in mdx mice. Biochimica et biophysica acta. Molecular cell research, 118917. https://doi.org/10.1016/j.bbamcr.2020.118917 PMID: 33259860",
                    "33259860"
                ],
                [
                    "Daria Morgoulis, Peter Berenstein, Simona Cazacu, Gila Kazimirsky, Amir Dori, Eytan R Barnea, Chaya Brodie (2019). sPIF promotes myoblast differentiation and utrophin expression while inhibiting fibrosis in Duchenne muscular dystrophy via the H19/miR-675/let-7 and miR-21 pathways. Cell death & disease, 82. https://doi.org/10.1038/s41419-019-1307-9 PMID: 30692507",
                    "30692507"
                ],
                [
                    "Ariel Bier, Peter Berenstein, Noam Kronfeld, Daria Morgoulis, Amotz Ziv-Av, Hodaya Goldstein, Gila Kazimirsky, Simona Cazacu, Rinat Meir, Rachela Popovtzer, Amir Dori, Chaya Brodie (2018). Placenta-derived mesenchymal stromal cells and their exosomes exert therapeutic effects in Duchenne muscular dystrophy. Biomaterials, 67-78. https://doi.org/10.1016/j.biomaterials.2018.04.055 PMID: 29783118",
                    "29783118"
                ],
                [
                    "Justin R Fallon, Elizabeth M McNally (2018). Non-Glycanated Biglycan and LTBP4: Leveraging the extracellular matrix for Duchenne Muscular Dystrophy therapeutics. Matrix biology : journal of the International Society for Matrix Biology, 616-627. https://doi.org/10.1016/j.matbio.2018.02.016 PMID: 29481844",
                    "29481844"
                ],
                [
                    "Christopher Ballmann, Thomas S Denney, Ronald J Beyers, Tiffany Quindry, Matthew Romero, Rajesh Amin, Joshua T Selsby, John C Quindry (2017). Lifelong quercetin enrichment and cardioprotection in Mdx/Utrn+/- mice. American journal of physiology. Heart and circulatory physiology, H128-H140. https://doi.org/10.1152/ajpheart.00552.2016 PMID: 27836895",
                    "27836895"
                ],
                [
                    "Christopher Ballmann, Katrin Hollinger, Joshua T Selsby, Rajesh Amin, John C Quindry (2015). Histological and biochemical outcomes of cardiac pathology in mdx mice with dietary quercetin enrichment. Experimental physiology, 12-22. https://doi.org/10.1113/expphysiol.2014.083360 PMID: 25557727",
                    "25557727"
                ],
                [
                    "Urs T Ruegg (2013). Pharmacological prospects in the treatment of Duchenne muscular dystrophy. Current opinion in neurology, 577-84. https://doi.org/10.1097/WCO.0b013e328364fbaf PMID: 23995279",
                    "23995279"
                ],
                [
                    "Rebecca J Fairclough, Kelly J Perkins, Kay E Davies (2012). Pharmacologically targeting the primary defect and downstream pathology in Duchenne muscular dystrophy. Current gene therapy, 206-44. https://doi.org/10.2174/156652312800840595 PMID: 22571500",
                    "22571500"
                ]
            ]
        ],
        [
            [
                "HDAC",
                "TGFB1"
            ],
            0.7260498999999999,
            [
                [
                    "Chia-Hao Liu, Hong-Sheng Lee, Jing-Ping Liou, Hung-Sheng Hua, Wun-Hao Cheng, Fara Silvia Yuliani, Bing-Chang Chen, Chien-Huang Lin (2024). MPT0E028, a novel pan-HDAC inhibitor, prevents pulmonary fibrosis through inhibition of TGF-β-induced CTGF expression in human lung fibroblasts: Involvement of MKP-1 activation. European journal of pharmacology, 176711. https://doi.org/10.1016/j.ejphar.2024.176711 PMID: 38839029",
                    "38839029"
                ],
                [
                    "Fangzhou Lv, Laidi Xie, Lei Li, Jiafeng Lin (2024). LMK235 ameliorates inflammation and fibrosis after myocardial infarction by inhibiting LSD1-related pathway. Scientific reports, 23450. https://doi.org/10.1038/s41598-024-74887-3 PMID: 39379699",
                    "39379699"
                ],
                [
                    "Daichi Ishii, Yuma Shindo, Wataru Arai, Takumi Konno, Takayuki Kohno, Kazuya Honda, Masahiro Miyajima, Atsushi Watanabe, Takashi Kojima (2024). The Roles and Regulatory Mechanisms of Tight Junction Protein Cingulin and Transcription Factor Forkhead Box Protein O1 in Human Lung Adenocarcinoma A549 Cells and Normal Lung Epithelial Cells. International journal of molecular sciences. https://doi.org/10.3390/ijms25031411 PMID: 38338691",
                    "38338691"
                ],
                [
                    "Hui-Wen Yang, Yi-Hwa Sun, Chih-Yuan Fang, Yoichi Ohiro, Heng-Yi Liao, Yi-Wen Liao, Yu-Hsun Kao, Cheng-Chia Yu (2023). Downregulation of histone deacetylase 8 (HDAC8) alleviated the progression of oral submucous fibrosis. Journal of dental sciences, 652-658. https://doi.org/10.1016/j.jds.2022.10.007 PMID: 37021220",
                    "37021220"
                ],
                [
                    "Fahad Hussain Mohammed, Franz Cemic, Jürgen Hemberger, Shibashish Giri (2023). Biological skin regeneration using epigenetic targets. Drug discovery today, 103495. https://doi.org/10.1016/j.drudis.2023.103495 PMID: 36681237",
                    "36681237"
                ],
                [
                    "Yoshihiro Mezawa, Tingwei Wang, Yataro Daigo, Atsushi Takano, Yohei Miyagi, Tomoyuki Yokose, Toshinari Yamashita, Liying Yang, Reo Maruyama, Hiroyuki Seimiya, Akira Orimo (2023). Glutamine deficiency drives transforming growth factor-β signaling activation that gives rise to myofibroblastic carcinoma-associated fibroblasts. Cancer science, 4376-4387. https://doi.org/10.1111/cas.15955 PMID: 37706357",
                    "37706357"
                ],
                [
                    "Rodrigo A Vargas, Sarita Soto-Aguilera, Mick Parra, Sebastian Herrera, Alvaro Santibañez, Camila Kossack, Claudia P Saavedra, Oscar Mora, Mauricio Pineda, Oscar Gonzalez, Alex Gonzalez, Kevin Maisey, Edgar Torres-Maravilla, Luis G Bermúdez-Humarán, Elkin Y Suárez-Villota, Mario Tello (2023). Analysis of microbiota-host communication mediated by butyrate in Atlantic salmon. Computational and structural biotechnology journal, 2558-2578. https://doi.org/10.1016/j.csbj.2023.03.050 PMID: 37122632",
                    "37122632"
                ],
                [
                    "Lifang Chen, Jianyu He, Yirong Zhang, Yiqiao Li, Teng Zhang, Rong Wang, Liang Bai, Sihai Zhao, Enqi Liu, Weirong Wang (2023). Regulation of endothelial-to-mesenchymal transition by histone deacetylase 3 posttranslational modifications in neointimal hyperplasia. Annals of translational medicine, 207. https://doi.org/10.21037/atm-22-4371 PMID: 37007585",
                    "37007585"
                ],
                [
                    "Zahra Behroozi, Keihan Kookli, Alireza Ghadaksaz, Mahsa Motavaf, Seyedalireza Moghaddas Fazeli, Ali Motamed Nezhad, Fatemeh Ramezani, Atousa Janzadeh (2023). Evaluation of epigenetic (HDAC, DNMT) and pain (Gad65, TGF) factors following photobiomodulation therapy in a neuropathic pain model. Photochemistry and photobiology. https://doi.org/10.1111/php.13824 PMID: 37332186",
                    "37332186"
                ],
                [
                    "Kai Tie, Zhe Zhao, Zhixin Wu, Jun Qin, Jinzhi Zhang, Linguo Pei, Hui Wang, Liaobin Chen (2022). Low miR-92a-3p in oocytes mediates the multigenerational and transgenerational inheritance of poor cartilage quality in rat induced by prenatal dexamethasone exposure. Biochemical pharmacology, 115196. https://doi.org/10.1016/j.bcp.2022.115196 PMID: 35917869",
                    "35917869"
                ]
            ]
        ],
        [
            [
                "DMD",
                "Muscular Dystrophy, Duchenne"
            ],
            30.699568,
            [
                [
                    "Harunobu Muto, Yoshihiko Yu, James K Chambers, Lyndon M Coghill, Yasuharu Nakamura, Kazuyuki Uchida, Leslie A Lyons (2024). Association of a novel dystrophin (DMD) genetic nonsense variant in a cat with X-linked muscular dystrophy with a mild clinical course. Journal of veterinary internal medicine, 1160-1166. https://doi.org/10.1111/jvim.17024 PMID: 38415938",
                    "38415938"
                ],
                [
                    "Caroline Covatti, Daniela Sayuri Mizobuti, Guilherme Luiz da Rocha, Heloina Nathalliê Mariano da Silva, Elaine Minatel (2024). Photobiomodulation Therapy Effects at Different Stages of the Dystrophic Phenotype: A Histomorphometric Study. Journal of manipulative and physiological therapeutics, 142-154. https://doi.org/10.1016/j.jmpt.2024.09.008 PMID: 39453299",
                    "39453299"
                ],
                [
                    "Jeffrey J Widrick, Matthias R Lambert, Felipe de Souza Leite, Youngsook Lucy Jung, Junseok Park, James R Conner, Eunjung Alice Lee, Alan H Beggs, Louis M Kunkel (2024). High resolution kinematic approach for quantifying impaired mobility of dystrophic zebrafish larvae. bioRxiv : the preprint server for biology. https://doi.org/10.1101/2024.12.05.627004 PMID: 39713379",
                    "39713379"
                ],
                [
                    "Vahid Omarmeli, Kai-Uwe Lewandrowski, Marjan Assefi, Hanieh Faizmahdavi, Alireza Sharafshah, Nasrin Mansouri (2024). A Novel Mutation (Lys31Arg) in the DMD Gene Impacts on Neuromuscular Dysfunctions Found by Whole Exome Sequencing and In Silico Analyses in an Iranian Family. Current aging science, 169-174. https://doi.org/10.2174/0118746098280408240112112414 PMID: 38265407",
                    "38265407"
                ],
                [
                    "David M Rind (2024). The FDA and Gene Therapy for Duchenne Muscular Dystrophy. JAMA, 1705-1706. https://doi.org/10.1001/jama.2024.5613 PMID: 38691382",
                    "38691382"
                ],
                [
                    "X Qiu, J J Guo, C C Jin, J He, L Wang, B C Yang, Y H Zhang, B S Zhu, X H Tang (2024). [Efficiency of CNV-seq in detecting fetal DMD gene deletion or duplication in prenatal diagnosis]. Zhonghua fu chan ke za zhi, 279-287. https://doi.org/10.3760/cma.j.cn112141-20230919-00107 PMID: 38644274",
                    "38644274"
                ],
                [
                    "Nalaka Wijekoon, Lakmal Gonawala, Pyara Ratnayake, Pulasthi Dissanayaka, Isuru Gunarathne, Dhammika Amaratunga, Roshan Liyanage, Sunethra Senanayaka, Saraji Wijesekara, Hemal H Gunasekara, Kamala Vanarsa, Jessica Castillo, Yetrib Hathout, Ashwin Dalal, Harry W M Steinbusch, Eric Hoffman, Chandra Mohan, K Ranil D de Silva (2023). Integrated genomic, proteomic and cognitive assessment in Duchenne Muscular Dystrophy suggest astrocyte centric pathology. Heliyon, e18530. https://doi.org/10.1016/j.heliyon.2023.e18530 PMID: 37593636",
                    "37593636"
                ],
                [
                    "Adi Amar-Schwartz, Yuval Cohen, Antony Elhaj, Vered Ben-Hur, Zahava Siegfried, Rotem Karni, Talya Dor (2023). Inhibition of nonsense-mediated mRNA decay may improve stop codon read-through therapy for Duchenne muscular dystrophy. Human molecular genetics, 2455-2463. https://doi.org/10.1093/hmg/ddad072 PMID: 37145099",
                    "37145099"
                ],
                [
                    "Akitoshi Chikamoto, Ryota Tochinai, Shin-Ichi Sekizawa, Masayoshi Kuwahara (2023). Plasticity occurs in a specific phenotype of neurons in the nucleus tractus solitarius of dystrophin gene-mutated rats. The European journal of neuroscience, 4282-4297. https://doi.org/10.1111/ejn.16179 PMID: 37933572",
                    "37933572"
                ],
                [
                    "Michael N Maxwell, Anthony L Marullo, Aoife D Slyne, Eric F Lucking, Ken D O'Halloran (2023). Ventilatory Effects of Acute Intermittent Hypoxia in Conscious Dystrophic Mice. Advances in experimental medicine and biology, 83-88. https://doi.org/10.1007/978-3-031-32371-3_9 PMID: 37322338",
                    "37322338"
                ]
            ]
        ],
        [
            [
                "MSTN",
                "TGFB1"
            ],
            0.7260498999999999,
            [
                [
                    "Hyeon-Jeong Lee, Jiin Hwang, Yoondam Seo, Gahyeon Lee, Hwa Jeong Lee, Hophil Min (2025). Simultaneous detection of myostatin-targeting monoclonal antibodies in dried blood spots and plasma using liquid chromatography-tandem mass spectrometry with field asymmetric ion mobility spectrometry. Journal of pharmaceutical and biomedical analysis, 116518. https://doi.org/10.1016/j.jpba.2024.116518 PMID: 39405785",
                    "39405785"
                ],
                [
                    "Andi Shi, Chuqi He, Kirsten Otten, Gang Wu, Tymour Forouzanfar, Rob C I Wüst, Richard T Jaspers (2024). Reduced myotube diameter induced by combined inhibition of transforming growth factor-β type I receptors Acvr1b and Tgfbr1 is associated with enhanced β1-syntrophin expression. Journal of cellular physiology, e31418. https://doi.org/10.1002/jcp.31418 PMID: 39164996",
                    "39164996"
                ],
                [
                    "R Curcio, L Nunziangeli, E Nulli Migliola, F Battista, M D'Abbondanza, F Anastasio, M E Crapa, L Sanesi, G Pucci, G Vaudo (2024). Serum Myostatin is Associated With Central-to-Peripheral Arterial Stiffness Gradient in Healthy Adolescents: The MACISTE Study. American journal of hypertension, 777-783. https://doi.org/10.1093/ajh/hpae089 PMID: 39016523",
                    "39016523"
                ],
                [
                    "Hao Zuo, Wei Jiang, Jianwei Gao, Zhibo Ma, Chen Li, Yaxin Peng, Jianjun Jin, Xizhen Zhan, Wei Lv, Xiao Liu, Jingjing Hu, Mengdi Zhang, Yiming Jia, Zaiyan Xu, Junming Tang, Rong Zheng, Bo Zuo (2024). SYISL Knockout Promotes Embryonic Muscle Development of Offspring by Modulating Maternal Gut Microbiota and Fetal Myogenic Cell Dynamics. Advanced science (Weinheim, Baden-Wurttemberg, Germany), e2410953. https://doi.org/10.1002/advs.202410953 PMID: 39680624",
                    "39680624"
                ],
                [
                    "Platon Braun, Malik Alawi, Ceren Saygi, Klaus Pantel, Amy J Wagers (2024). Expression profiling by high-throughput sequencing reveals GADD45, SMAD7, EGR-1 and HOXA3 activation in Myostatin (MSTN) and GDF11 treated myoblasts. Genetics and molecular biology, e20230304. https://doi.org/10.1590/1678-4685-GMB-2023-0304 PMID: 39012095",
                    "39012095"
                ],
                [
                    "Emel Özcan Gökçek, Raziye Işık, Bilge Karahan, Kutsal Gamsız (2023). Characterisation of Single Nucleotide Polymorphisms and Haplotypes of MSTN Associated with Growth Traits in European Sea Bass (Dicentrarchus labrax). Marine biotechnology (New York, N.Y.), 347-357. https://doi.org/10.1007/s10126-023-10211-w PMID: 37162623",
                    "37162623"
                ],
                [
                    "Katja Walpurgis, Johannes Agricola, Andreas Thomas, Mario Thevis (2023). Myostatin inhibitory peptides in sports drug testing. Drug testing and analysis, 1477-1487. https://doi.org/10.1002/dta.3473 PMID: 36946003",
                    "36946003"
                ],
                [
                    "Jiaye Chen, Tinglin Song, Sizhu Yang, Qingxue Meng, Xiaoyu Han, Ze Wu, Jung-Chien Cheng, Lanlan Fang (2023). Snail mediates GDF-8-stimulated human extravillous trophoblast cell invasion by upregulating MMP2 expression. Cell communication and signaling : CCS, 93. https://doi.org/10.1186/s12964-023-01107-2 PMID: 37143106",
                    "37143106"
                ],
                [
                    "Xin-Hua Liu, Jiang Ping Pan, William A Bauman, Christopher Cardozo (2022). Myostatin inhibits insulin-like growth factor 1-dependent citrate secretion and osteogenesis via nicotinamide adenine dinucleotide phosphate oxidase-4 in a mouse mesenchymal stem cell line. Annals of the New York Academy of Sciences, 203-212. https://doi.org/10.1111/nyas.14894 PMID: 36072988",
                    "36072988"
                ],
                [
                    "Sijia Wang, Lanlan Fang, Luping Cong, Jacqueline Pui Wah Chung, Tin Chiu Li, David Yiu Leung Chan (2022). Myostatin: a multifunctional role in human female reproduction and fertility - a short review. Reproductive biology and endocrinology : RB&E, 96. https://doi.org/10.1186/s12958-022-00969-4 PMID: 35780124",
                    "35780124"
                ]
            ]
        ],
        [
            [
                "utrophin",
                "MSTN"
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            1.1798203999999999,
            [
                [
                    "Robin N Michel, Eva R Chin, Joe V Chakkalakal, Joe K Eibl, Bernard J Jasmin (2007). Ca2+/calmodulin-based signalling in the regulation of the muscle fibre phenotype and its therapeutic potential via modulation of utrophin A and myostatin expression. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 921-9. https://doi.org/10.1139/H07-093 PMID: 18059617",
                    "18059617"
                ],
                [
                    "Vincent Voisin, Sabine de la Porte (2005). [Pharmacological treatments for Duchenne and Becker dystrophies]. Journal de la Societe de biologie, 17-28. https://doi.org/10.1051/jbio:2005003 PMID: 16114260",
                    "16114260"
                ],
                [
                    "Joe V Chakkalakal, Jennifer Thompson, Robin J Parks, Bernard J Jasmin (2005). Molecular, cellular, and pharmacological therapies for Duchenne/Becker muscular dystrophies. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 880-91. https://doi.org/10.1096/fj.04-1956rev PMID: 15923398",
                    "15923398"
                ],
                [
                    "Sasha Bogdanovich, Kelly J Perkins, Thomas O B Krag, Lisa-Anne Whittemore, Tejvir S Khurana (2005). Myostatin propeptide-mediated amelioration of dystrophic pathophysiology. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 543-9. https://doi.org/10.1096/fj.04-2796com PMID: 15791004",
                    "15791004"
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                [
                    "O Schakman, S Kalista, C Barbé, A Loumaye, J P Thissen (2013). Glucocorticoid-induced skeletal muscle atrophy. The international journal of biochemistry & cell biology, 2163-72. PMID: 23806868",
                    "23806868"
                ],
                [
                    "Huitao Fan, Rui Zhang, Dawit Tesfaye, Ernst Tholen, Christian Looft, Michael Hölker, Karl Schellander, Mehmet Ulas Cinar (2012). Sulforaphane causes a major epigenetic repression of myostatin in porcine satellite cells. Epigenetics, 1379-90. https://doi.org/10.4161/epi.22609 PMID: 23092945",
                    "23092945"
                ],
                [
                    "Der-Sheng Han, Hsiang-Po Huang, Tyng-Guey Wang, Meng-Yu Hung, Jia-Yu Ke, Kuei-Ting Chang, Hsin-Yu Chang, Yu-Ping Ho, Wei-Yuan Hsieh, Wei-Shiung Yang (2010). Transcription activation of myostatin by trichostatin A in differentiated C2C12 myocytes via ASK1-MKK3/4/6-JNK and p38 mitogen-activated protein kinase pathways. Journal of cellular biochemistry, 564-73. https://doi.org/10.1002/jcb.22740 PMID: 20568119",
                    "20568119"
                ]
            ]
        ],
        [
            [
                "HDAC",
                "Transforming Growth Factor beta"
            ],
            0.6583711,
            [
                [
                    "Chia-Hao Liu, Hong-Sheng Lee, Jing-Ping Liou, Hung-Sheng Hua, Wun-Hao Cheng, Fara Silvia Yuliani, Bing-Chang Chen, Chien-Huang Lin (2024). MPT0E028, a novel pan-HDAC inhibitor, prevents pulmonary fibrosis through inhibition of TGF-β-induced CTGF expression in human lung fibroblasts: Involvement of MKP-1 activation. European journal of pharmacology, 176711. https://doi.org/10.1016/j.ejphar.2024.176711 PMID: 38839029",
                    "38839029"
                ],
                [
                    "Jui M Dave, Raja Chakraborty, Alex Agyemang, Aglaia Ntokou, Junichi Saito, Praveen Ballabh, Kathleen A Martin, Daniel M Greif (2024). Loss of TGFβ-Mediated Repression of Angiopoietin-2 in Pericytes Underlies Germinal Matrix Hemorrhage Pathogenesis. Stroke, 2340-2352. https://doi.org/10.1161/STROKEAHA.123.045248 PMID: 39129597",
                    "39129597"
                ],
                [
                    "Hyeong Ju Byeon, Soo Hyun Choi, Don O Kikkawa, Jaesang Ko, Jin Sook Yoon (2024). Therapeutic role of histone deacetylase inhibition in an in vitro model of Graves' orbitopathy. Molecular medicine reports. PMID: 39329199",
                    "39329199"
                ],
                [
                    "Fahad Hussain Mohammed, Franz Cemic, Jürgen Hemberger, Shibashish Giri (2023). Biological skin regeneration using epigenetic targets. Drug discovery today, 103495. https://doi.org/10.1016/j.drudis.2023.103495 PMID: 36681237",
                    "36681237"
                ],
                [
                    "Lydie Plecitá-Hlavatá, Andrea Brázdová, Monika Křivonosková, Cheng-Jun Hu, Tzu Phang, Jan Tauber, Min Li, Hui Zhang, Konrad Hoetzenecker, Slaven Crnkovic, Grazyna Kwapiszewska, Kurt R Stenmark (2023). Microenvironmental regulation of T-cells in pulmonary hypertension. Frontiers in immunology, 1223122. https://doi.org/10.3389/fimmu.2023.1223122 PMID: 37497214",
                    "37497214"
                ],
                [
                    "Yoshihiro Mezawa, Tingwei Wang, Yataro Daigo, Atsushi Takano, Yohei Miyagi, Tomoyuki Yokose, Toshinari Yamashita, Liying Yang, Reo Maruyama, Hiroyuki Seimiya, Akira Orimo (2023). Glutamine deficiency drives transforming growth factor-β signaling activation that gives rise to myofibroblastic carcinoma-associated fibroblasts. Cancer science, 4376-4387. https://doi.org/10.1111/cas.15955 PMID: 37706357",
                    "37706357"
                ],
                [
                    "Zahra Behroozi, Keihan Kookli, Alireza Ghadaksaz, Mahsa Motavaf, Seyedalireza Moghaddas Fazeli, Ali Motamed Nezhad, Fatemeh Ramezani, Atousa Janzadeh (2023). Evaluation of epigenetic (HDAC, DNMT) and pain (Gad65, TGF) factors following photobiomodulation therapy in a neuropathic pain model. Photochemistry and photobiology. https://doi.org/10.1111/php.13824 PMID: 37332186",
                    "37332186"
                ],
                [
                    "Amy Lewis, David T Humphreys, Belen Pan-Castillo, Giulio Berti, Carla Felice, Hannah Gordon, Radha Gadhok, Anke Nijhuis, Shameer Mehta S, Liliane Eleid, Sidra Iqbal, Alessandro Armuzzi, Annamaria Minicozzi, Eleni Giannoulatou, Joanne ChinAleong, Roger Feakins, Virag Sagi-Kiss, Dora Barisic, Margarita-Ioanna Koufaki, Jacob G Bundy, James O Lindsay, Andrew Silver (2023). Epigenetic and metabolic reprogramming of fibroblasts in Crohn's disease strictures reveals histone deacetylases as therapeutic targets. Journal of Crohn's & colitis. https://doi.org/10.1093/ecco-jcc/jjad209 PMID: 38069679",
                    "38069679"
                ],
                [
                    "Wei-Chieh Yu, Tsung-Yu Yeh, Chih-Hung Ye, Patrick Chun Theng Chong, Yi-Hsun Ho, Dorothy Kazuno So, Kah Yi Yap, Guan-Ru Peng, Chi-Hsuan Shao, Ajit Dhananjay Jagtap, Ji-Wang Chern, Chen-Si Lin, Shau-Ping Lin, Shuei-Liong Lin, Shu-Han Yu, Chao-Wu Yu (2023). Discovery of HDAC6, HDAC8, and 6/8 Inhibitors and Development of Cell-Based Drug Screening Models for the Treatment of TGF-β-Induced Idiopathic Pulmonary Fibrosis. Journal of medicinal chemistry, 10528-10557. https://doi.org/10.1021/acs.jmedchem.3c00644 PMID: 37463500",
                    "37463500"
                ],
                [
                    "Kai Tie, Zhe Zhao, Zhixin Wu, Jun Qin, Jinzhi Zhang, Linguo Pei, Hui Wang, Liaobin Chen (2022). Low miR-92a-3p in oocytes mediates the multigenerational and transgenerational inheritance of poor cartilage quality in rat induced by prenatal dexamethasone exposure. Biochemical pharmacology, 115196. https://doi.org/10.1016/j.bcp.2022.115196 PMID: 35917869",
                    "35917869"
                ]
            ]
        ],
        [
            [
                "utrophin",
                "Transforming Growth Factor beta"
            ],
            0.6583711,
            [
                [
                    "Benjamin R Pryce, Cédrik Labrèche, Dounia Hamoudi, John Abou-Hamad, Khalid N Al-Zahrani, Jonathan J Hodgins, Antoine Boulanger-Piette, Sabrina Bossé, Cindy Balog-Alvarez, Jérôme Frénette, Michele Ardolino, Joe N Kornegay, Luc A Sabourin (2021). Muscle-specific deletion of SLK/Stk2 enhances p38 activity and myogenesis in mdx mice. Biochimica et biophysica acta. Molecular cell research, 118917. https://doi.org/10.1016/j.bbamcr.2020.118917 PMID: 33259860",
                    "33259860"
                ],
                [
                    "Gili Wellner, Sharon Mordechay, Paul Evans, Olga Genin, Mark Pines, Orna Halevy (2019). Hydroxy group requirement for halofuginone-dependent inhibition of muscle fibrosis and improvement of histopathology in the mdx mouse model for Duchenne muscular dystrophy. Histology and histopathology, 791-801. https://doi.org/10.14670/HH-18-083 PMID: 30628720",
                    "30628720"
                ],
                [
                    "Ariel Bier, Peter Berenstein, Noam Kronfeld, Daria Morgoulis, Amotz Ziv-Av, Hodaya Goldstein, Gila Kazimirsky, Simona Cazacu, Rinat Meir, Rachela Popovtzer, Amir Dori, Chaya Brodie (2018). Placenta-derived mesenchymal stromal cells and their exosomes exert therapeutic effects in Duchenne muscular dystrophy. Biomaterials, 67-78. https://doi.org/10.1016/j.biomaterials.2018.04.055 PMID: 29783118",
                    "29783118"
                ],
                [
                    "Lee G Fradkin, Richard A Baines, Mariska C van der Plas, Jasprina N Noordermeer (2008). The dystrophin Dp186 isoform regulates neurotransmitter release at a central synapse in Drosophila. The Journal of neuroscience : the official journal of the Society for Neuroscience, 5105-14. https://doi.org/10.1523/JNEUROSCI.4950-07.2008 PMID: 18463264",
                    "18463264"
                ],
                [
                    "Robin N Michel, Eva R Chin, Joe V Chakkalakal, Joe K Eibl, Bernard J Jasmin (2007). Ca2+/calmodulin-based signalling in the regulation of the muscle fibre phenotype and its therapeutic potential via modulation of utrophin A and myostatin expression. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 921-9. https://doi.org/10.1139/H07-093 PMID: 18059617",
                    "18059617"
                ],
                [
                    "Vincent Voisin, Sabine de la Porte (2005). [Pharmacological treatments for Duchenne and Becker dystrophies]. Journal de la Societe de biologie, 17-28. https://doi.org/10.1051/jbio:2005003 PMID: 16114260",
                    "16114260"
                ],
                [
                    "Joe V Chakkalakal, Jennifer Thompson, Robin J Parks, Bernard J Jasmin (2005). Molecular, cellular, and pharmacological therapies for Duchenne/Becker muscular dystrophies. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 880-91. https://doi.org/10.1096/fj.04-1956rev PMID: 15923398",
                    "15923398"
                ],
                [
                    "Annamaria De Luca, Beatrice Nico, Antonella Liantonio, Maria Paola Didonna, Bodvael Fraysse, Sabata Pierno, Rosa Burdi, Domenica Mangieri, Jean-François Rolland, Claudia Camerino, Alberta Zallone, Paolo Confalonieri, Francesca Andreetta, Elisa Arnoldi, Isabelle Courdier-Fruh, Josef P Magyar, Antonio Frigeri, Michela Pisoni, Maria Svelto, Diana Conte Camerino (2005). A multidisciplinary evaluation of the effectiveness of cyclosporine a in dystrophic mdx mice. The American journal of pathology, 477-89. https://doi.org/10.1016/S0002-9440(10)62270-5 PMID: 15681831",
                    "15681831"
                ],
                [
                    "Sasha Bogdanovich, Kelly J Perkins, Thomas O B Krag, Lisa-Anne Whittemore, Tejvir S Khurana (2005). Myostatin propeptide-mediated amelioration of dystrophic pathophysiology. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 543-9. https://doi.org/10.1096/fj.04-2796com PMID: 15791004",
                    "15791004"
                ]
            ]
        ],
        [
            [
                "creatine kinase",
                "DMD"
            ],
            4.1355435,
            [
                [
                    "Harunobu Muto, Yoshihiko Yu, James K Chambers, Lyndon M Coghill, Yasuharu Nakamura, Kazuyuki Uchida, Leslie A Lyons (2024). Association of a novel dystrophin (DMD) genetic nonsense variant in a cat with X-linked muscular dystrophy with a mild clinical course. Journal of veterinary internal medicine, 1160-1166. https://doi.org/10.1111/jvim.17024 PMID: 38415938",
                    "38415938"
                ],
                [
                    "Masayoshi Otake, Michihiro Imamura, Satoko Enya, Akihisa Kangawa, Masatoshi Shibata, Kinuyo Ozaki, Koichi Kimura, Etsuro Ono, Yoshitsugu Aoki (2024). Severe cardiac and skeletal manifestations in DMD-edited microminipigs: an advanced surrogate for Duchenne muscular dystrophy. Communications biology, 523. https://doi.org/10.1038/s42003-024-06222-5 PMID: 38702481",
                    "38702481"
                ],
                [
                    "Mario Van Poucke, Liesbet Ledeganck, Ling T Guo, G Diane Shelton, Sofie F M Bhatti, Ine Cornelis, Luc Peelman (2024). Exonisation of an intronic L1 element in the dystrophin gene associated with X-linked muscular dystrophy in a Border Collie dog. Animal genetics, 733-743. https://doi.org/10.1111/age.13470 PMID: 39152696",
                    "39152696"
                ],
                [
                    "Kyriaki Kekou, Maria Svingou, Nikos Vogiatzakis, Evangelia Nitsa, Danai Veltra, Nikolaos M Marinakis, Faidon-Nikolaos Tilemis, Maria Tzetis, Anastasios Mitrakos, Charalambia Tsaroucha, Nicoletta Selenti, Giorgos-Konstantinos Papadimas, Constantinos Papadopoulos, Joanne Traeger-Synodinos, Hanns Lochmuller, Christalena Sofocleous (2023). Retrospective analysis of persistent HyperCKemia with or without muscle weakness in a case series from Greece highlights vast DMD variant heterogeneity. Expert review of molecular diagnostics, 999-1010. https://doi.org/10.1080/14737159.2023.2264181 PMID: 37754746",
                    "37754746"
                ],
                [
                    "Natalie Pluta, Arpad von Moers, Astrid Pechmann, Werner Stenzel, Hans-Hilmar Goebel, David Atlan, Beat Wolf, Indrajit Nanda, Ann-Kathrin Zaum, Simone Rost (2023). Whole-Genome Sequencing Identified New Structural Variations in the DMD Gene That Cause Duchenne Muscular Dystrophy in Two Girls. International journal of molecular sciences. https://doi.org/10.3390/ijms241713567 PMID: 37686372",
                    "37686372"
                ],
                [
                    "Ha Rim Shin, Eun-Ji Ko, Yun-Jeong Kang, Hak-Sun Yu, Mee Sun Ock, Hee-Jae Cha (2023). Effect of parasitic infection on muscular function of dystrophin gene (Dmd) deficient mouse. Genes & genomics, 183-190. https://doi.org/10.1007/s13258-022-01355-5 PMID: 36571712",
                    "36571712"
                ],
                [
                    "Evy Beckers, Ine Cornelis, Sofie F M Bhatti, Pascale Smets, G Diane Shelton, Ling T Guo, Luc Peelman, Bart J G Broeckx (2022). A Nonsense Variant in the DMD Gene Causes X-Linked Muscular Dystrophy in the Maine Coon Cat. Animals : an open access journal from MDPI. https://doi.org/10.3390/ani12212928 PMID: 36359052",
                    "36359052"
                ],
                [
                    "Leigh B Waddell, Samantha J Bryen, Beryl B Cummings, Adam Bournazos, Frances J Evesson, Himanshu Joshi, Jamie L Marshall, Taru Tukiainen, Elise Valkanas, Ben Weisburd, Simon Sadedin, Mark R Davis, Fathimath Faiz, Rebecca Gooding, Sarah A Sandaradura, Gina L O'Grady, Michel C Tchan, David R Mowat, Emily C Oates, Michelle A Farrar, Hugo Sampaio, Alan Ma, Katherine Neas, Min-Xia Wang, Amanda Charlton, Charles Chan, Diane N Kenwright, Nicole Graf, Susan Arbuckle, Nigel F Clarke, Daniel G MacArthur, Kristi J Jones, Monkol Lek, Sandra T Cooper (2021). WGS and RNA Studies Diagnose Noncoding DMD Variants in Males With High Creatine Kinase. Neurology. Genetics, e554. https://doi.org/10.1212/NXG.0000000000000554 PMID: 33977140",
                    "33977140"
                ],
                [
                    "Muhammet Gültekin Kutluk, Çağla Serpil Doğan (2020). Kidney involvement and associated risk factors in children with Duchenne muscular dystrophy. Pediatric nephrology (Berlin, Germany), 1953-1958. https://doi.org/10.1007/s00467-020-04587-3 PMID: 32447503",
                    "32447503"
                ],
                [
                    "Shuai Han, Hong Xu, Jinxian Zheng, Junhui Sun, Xue Feng, Yue Wang, Wen Ye, Qing Ke, Yanwei Ren, Shulie Yao, Songying Zhang, Jianfen Chen, Robert C Griggs, Zhengyan Zhao, Ming Qi, Michele A Gatheridge (2020). Population-Wide Duchenne Muscular Dystrophy Carrier Detection by CK and Molecular Testing. BioMed research international, 8396429. https://doi.org/10.1155/2020/8396429 PMID: 33029525",
                    "33029525"
                ]
            ]
        ],
        [
            [
                "MSTN",
                "Transforming Growth Factor beta"
            ],
            0.6583711,
            [
                [
                    "Platon Braun, Malik Alawi, Ceren Saygi, Klaus Pantel, Amy J Wagers (2024). Expression profiling by high-throughput sequencing reveals GADD45, SMAD7, EGR-1 and HOXA3 activation in Myostatin (MSTN) and GDF11 treated myoblasts. Genetics and molecular biology, e20230304. https://doi.org/10.1590/1678-4685-GMB-2023-0304 PMID: 39012095",
                    "39012095"
                ],
                [
                    "Jiaye Chen, Tinglin Song, Sizhu Yang, Qingxue Meng, Xiaoyu Han, Ze Wu, Jung-Chien Cheng, Lanlan Fang (2023). Snail mediates GDF-8-stimulated human extravillous trophoblast cell invasion by upregulating MMP2 expression. Cell communication and signaling : CCS, 93. https://doi.org/10.1186/s12964-023-01107-2 PMID: 37143106",
                    "37143106"
                ],
                [
                    "John Lian, Ryan G Walker, Andrea D'Amico, Ana Vujic, Melanie J Mills, Kathleen A Messemer, Kourtney R Mendello, Jill M Goldstein, Krystynne A Leacock, Soraya Epp, Emma V Stimpfl, Thomas B Thompson, Amy J Wagers, Richard T Lee (2023). Functional substitutions of amino acids that differ between GDF11 and GDF8 impact skeletal development and skeletal muscle. Life science alliance. https://doi.org/10.26508/lsa.202201662 PMID: 36631218",
                    "36631218"
                ],
                [
                    "Sijia Wang, Lanlan Fang, Luping Cong, Jacqueline Pui Wah Chung, Tin Chiu Li, David Yiu Leung Chan (2022). Myostatin: a multifunctional role in human female reproduction and fertility - a short review. Reproductive biology and endocrinology : RB&E, 96. https://doi.org/10.1186/s12958-022-00969-4 PMID: 35780124",
                    "35780124"
                ],
                [
                    "Lanlan Fang, Zhen Wang, Ze Wu, Yang Yan, Yibo Gao, Yuxi Li, Jung-Chien Cheng, Ying-Pu Sun (2021). GDF-8 stimulates trophoblast cell invasion by inducing ALK5-SMAD2/3-mediated MMP2 expression. Reproduction (Cambridge, England), 331-338. https://doi.org/10.1530/REP-21-0197 PMID: 34432647",
                    "34432647"
                ],
                [
                    "Long Bai, Huihui Pan, Yinjun Zhao, Qingqing Chen, Yu Xiang, Xiaohang Yang, Yimin Zhu (2021). The Exploration of Poor Ovarian Response-Related Risk Factors: A Potential Role of Growth Differentiation Factor 8 in Predicting Ovarian Response in IVF-ET Patient. Frontiers in endocrinology, 708089. https://doi.org/10.3389/fendo.2021.708089 PMID: 34630324",
                    "34630324"
                ],
                [
                    "Yutaro Hayashi, Sumiko Mikawa, Chikara Ogawa, Kazuma Masumoto, Fuminori Katou, Kohji Sato (2018). Myostatin expression in the adult rat central nervous system. Journal of chemical neuroanatomy, 125-138. https://doi.org/10.1016/j.jchemneu.2018.10.001 PMID: 30366029",
                    "30366029"
                ],
                [
                    "Ryan G Walker, Jason C McCoy, Magdalena Czepnik, Melanie J Mills, Adam Hagg, Kelly L Walton, Thomas R Cotton, Marko Hyvönen, Richard T Lee, Paul Gregorevic, Craig A Harrison, Thomas B Thompson (2018). Molecular characterization of latent GDF8 reveals mechanisms of activation. Proceedings of the National Academy of Sciences of the United States of America, E866-E875. https://doi.org/10.1073/pnas.1714622115 PMID: 29348202",
                    "29348202"
                ],
                [
                    "Jinyue Wang, Xiaohong Wang, Weidou Feng (2017). Reloading Promotes Recovery of Disuse Muscle Loss by Inhibiting TGFβ Pathway Activation in Rats After Hind Limb Suspension. American journal of physical medicine & rehabilitation, 430-437. https://doi.org/10.1097/PHM.0000000000000617 PMID: 27610551",
                    "27610551"
                ],
                [
                    "Hrvoje Augustin, Kieran McGourty, Joern R Steinert, Helena M Cochemé, Jennifer Adcott, Melissa Cabecinha, Alec Vincent, Els F Halff, Josef T Kittler, Emmanuel Boucrot, Linda Partridge (2017). Myostatin-like proteins regulate synaptic function and neuronal morphology. Development (Cambridge, England), 2445-2455. https://doi.org/10.1242/dev.152975 PMID: 28533206",
                    "28533206"
                ]
            ]
        ],
        [
            [
                "HDAC",
                "myostatin"
            ],
            1.0635987,
            [
                [
                    "Min Chul Cho, Won Hoon Song, Jae-Seung Paick (2018). Suppression of Cavernosal Fibrosis in a Rat Model. Sexual medicine reviews, 572-582. https://doi.org/10.1016/j.sxmr.2018.02.007 PMID: 29631978",
                    "29631978"
                ],
                [
                    "O Schakman, S Kalista, C Barbé, A Loumaye, J P Thissen (2013). Glucocorticoid-induced skeletal muscle atrophy. The international journal of biochemistry & cell biology, 2163-72. PMID: 23806868",
                    "23806868"
                ],
                [
                    "Huitao Fan, Rui Zhang, Dawit Tesfaye, Ernst Tholen, Christian Looft, Michael Hölker, Karl Schellander, Mehmet Ulas Cinar (2012). Sulforaphane causes a major epigenetic repression of myostatin in porcine satellite cells. Epigenetics, 1379-90. https://doi.org/10.4161/epi.22609 PMID: 23092945",
                    "23092945"
                ],
                [
                    "Der-Sheng Han, Hsiang-Po Huang, Tyng-Guey Wang, Meng-Yu Hung, Jia-Yu Ke, Kuei-Ting Chang, Hsin-Yu Chang, Yu-Ping Ho, Wei-Yuan Hsieh, Wei-Shiung Yang (2010). Transcription activation of myostatin by trichostatin A in differentiated C2C12 myocytes via ASK1-MKK3/4/6-JNK and p38 mitogen-activated protein kinase pathways. Journal of cellular biochemistry, 564-73. https://doi.org/10.1002/jcb.22740 PMID: 20568119",
                    "20568119"
                ],
                [
                    "Simona Iezzi, Monica Di Padova, Carlo Serra, Giuseppina Caretti, Cristiano Simone, Eric Maklan, Giulia Minetti, Po Zhao, Eric P Hoffman, Pier Lorenzo Puri, Vittorio Sartorelli (2004). Deacetylase inhibitors increase muscle cell size by promoting myoblast recruitment and fusion through induction of follistatin. Developmental cell, 673-84. https://doi.org/10.1016/s1534-5807(04)00107-8 PMID: 15130492",
                    "15130492"
                ]
            ]
        ],
        [
            [
                "UTRN",
                "DMD"
            ],
            4.1355435,
            [
                [
                    "Satvik Mareedu, Nadezhda Fefelova, Cristi L Galindo, Goutham Prakash, Risa Mukai, Junichi Sadoshima, Lai-Hua Xie, Gopal J Babu (2024). Improved mitochondrial function in the hearts of sarcolipin-deficient dystrophin and utrophin double-knockout mice. JCI insight. PMID: 38564291",
                    "38564291"
                ],
                [
                    "Glen B Banks, Jeffrey S Chamberlain, Guy L Odom (2020). Microutrophin expression in dystrophic mice displays myofiber type differences in therapeutic effects. PLoS genetics, e1009179. https://doi.org/10.1371/journal.pgen.1009179 PMID: 33175853",
                    "33175853"
                ],
                [
                    "Cinzia Pisani, Georgios Strimpakos, Francesca Gabanella, Maria Grazia Di Certo, Annalisa Onori, Cinzia Severini, Siro Luvisetto, Stefano Farioli-Vecchioli, Irene Carrozzo, Antonio Esposito, Tamara Canu, Elisabetta Mattei, Nicoletta Corbi, Claudio Passananti (2018). Utrophin up-regulation by artificial transcription factors induces muscle rescue and impacts the neuromuscular junction in mdx mice. Biochimica et biophysica acta. Molecular basis of disease, 1172-1182. https://doi.org/10.1016/j.bbadis.2018.01.030 PMID: 29408646",
                    "29408646"
                ],
                [
                    "Antoine Boulanger Piette, Dounia Hamoudi, Laetitia Marcadet, Frédérique Kyomi Labelle, Rares Ovidiu David, Sabrina Bossé, Anteneh Argaw, Jérôme Frenette (2018). Utrophin haploinsufficiency does not worsen the functional performance, resistance to eccentric contractions and force production of dystrophic mice. PloS one, e0198408. https://doi.org/10.1371/journal.pone.0198408 PMID: 29879154",
                    "29879154"
                ],
                [
                    "Eun-Bee Cho, Wonjin Yoo, Sungjoo Kim Yoon, Jong-Bok Yoon (2018). β-dystroglycan is regulated by a balance between WWP1-mediated degradation and protection from WWP1 by dystrophin and utrophin. Biochimica et biophysica acta. Molecular basis of disease, 2199-2213. https://doi.org/10.1016/j.bbadis.2018.04.001 PMID: 29635000",
                    "29635000"
                ],
                [
                    "Jill A Rafael-Fortney, Jessica A Chadwick, Subha V Raman (2016). Duchenne Muscular Dystrophy Mice and Men: Can Understanding a Genetic Cardiomyopathy Inform Treatment of Other Myocardial Diseases? Circulation research, 1059-61. https://doi.org/10.1161/CIRCRESAHA.116.308402 PMID: 27034274",
                    "27034274"
                ],
                [
                    "Surinder M Singh, Swati Bandi, Krishna M G Mallela (2015). The N- and C-Terminal Domains Differentially Contribute to the Structure and Function of Dystrophin and Utrophin Tandem Calponin-Homology Domains. Biochemistry, 6942-50. https://doi.org/10.1021/acs.biochem.5b00969 PMID: 26516677",
                    "26516677"
                ],
                [
                    "Simon Guiraud, Annemieke Aartsma-Rus, Natassia M Vieira, Kay E Davies, Gert-Jan B van Ommen, Louis M Kunkel (2015). The Pathogenesis and Therapy of Muscular Dystrophies. Annual review of genomics and human genetics, 281-308. https://doi.org/10.1146/annurev-genom-090314-025003 PMID: 26048046",
                    "26048046"
                ],
                [
                    "Georgios Strimpakos, Nicoletta Corbi, Cinzia Pisani, Maria Grazia Di Certo, Annalisa Onori, Siro Luvisetto, Cinzia Severini, Francesca Gabanella, Lucia Monaco, Elisabetta Mattei, Claudio Passananti (2014). Novel adeno-associated viral vector delivering the utrophin gene regulator jazz counteracts dystrophic pathology in mdx mice. Journal of cellular physiology, 1283-91. https://doi.org/10.1002/jcp.24567 PMID: 24469912",
                    "24469912"
                ],
                [
                    "Camilla Pellegrini, Alessandra Zulian, Francesca Gualandi, Elisa Manzati, Luciano Merlini, Maria E Michelini, Luisa Benassi, Sandra Marmiroli, Alessandra Ferlini, Patrizia Sabatelli, Paolo Bernardi, Nadir M Maraldi (2013). Melanocytes--a novel tool to study mitochondrial dysfunction in Duchenne muscular dystrophy. Journal of cellular physiology, 1323-31. https://doi.org/10.1002/jcp.24290 PMID: 23169061",
                    "23169061"
                ]
            ]
        ],
        [
            [
                "HDAC",
                "DMD"
            ],
            4.1355435,
            [
                [
                    "Gist H Farr, Melanie Morris, Arianna Gomez, Thao Pham, Elisabeth Kilroy, Elizabeth U Parker, Shery Said, Clarissa Henry, Lisa Maves (2020). A novel chemical-combination screen in zebrafish identifies epigenetic small molecule candidates for the treatment of Duchenne muscular dystrophy. Skeletal muscle, 29. https://doi.org/10.1186/s13395-020-00251-4 PMID: 33059738",
                    "33059738"
                ]
            ]
        ],
        [
            [
                "UTRN",
                "myostatin"
            ],
            1.0635987,
            [
                [
                    "Robin N Michel, Eva R Chin, Joe V Chakkalakal, Joe K Eibl, Bernard J Jasmin (2007). Ca2+/calmodulin-based signalling in the regulation of the muscle fibre phenotype and its therapeutic potential via modulation of utrophin A and myostatin expression. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 921-9. https://doi.org/10.1139/H07-093 PMID: 18059617",
                    "18059617"
                ]
            ]
        ],
        [
            [
                "MSTN",
                "myostatin"
            ],
            1.0635987,
            [
                [
                    "Youn-Goo Kang, Joonhyuk Kwon, Soonjun Kwon, Ah-Ram Kim (2024). Synergistic Effects of Korean Mistletoe and Apple Peel Extracts on Muscle Strength and Endurance. Nutrients. https://doi.org/10.3390/nu16193255 PMID: 39408221",
                    "39408221"
                ],
                [
                    "Daniele Colombi, Giacomo Rovelli, Maria Gracia Luigi-Sierra, Simone Ceccobelli, Dailu Guan, Francesco Perini, Fiorella Sbarra, Andrea Quaglia, Francesca Maria Sarti, Marina Pasquini, Marcel Amills, Emiliano Lasagna (2024). Population structure and identification of genomic regions associated with productive traits in five Italian beef cattle breeds. Scientific reports, 8529. https://doi.org/10.1038/s41598-024-59269-z PMID: 38609445",
                    "38609445"
                ],
                [
                    "Ilva Trapina, Daina Kairisa, Samanta Plavina, Nikole Krasnevska, Jegors Paramonovs, Liga Senfelde, Natalia Paramonova (2024). The Multi-Loci Genotypes of the Myostatin Gene Associated with Growth Indicators of Intensively Fattened Lambs of Latvian Sheep. Animals : an open access journal from MDPI. https://doi.org/10.3390/ani14213143 PMID: 39518866",
                    "39518866"
                ],
                [
                    "Bosung Kim, Yejin Min, Yongdae Jeong, Sivasubramanian Ramani, Hyewon Lim, Yeonsu Jo, Woosang Kim, Yohan Choi, Sungkwon Park (2023). Comparison of growth performance and related gene expression of muscle and fat from Landrace, Yorkshire, and Duroc and Woori black pigs. Journal of animal science and technology, 160-174. https://doi.org/10.5187/jast.2022.e93 PMID: 37093948",
                    "37093948"
                ],
                [
                    "Mingjuan Gu, Song Wang, Anqi Di, Di Wu, Chao Hai, Xuefei Liu, Chunling Bai, Guanghua Su, Lei Yang, Guangpeng Li (2023). Combined Transcriptome and Metabolome Analysis of Smooth Muscle of Myostatin Knockout Cattle. International journal of molecular sciences. https://doi.org/10.3390/ijms24098120 PMID: 37175828",
                    "37175828"
                ],
                [
                    "Mingming Chen, Yue Zhao, Yao Li, Tiantian Chen, Wendi Zhou, Xiaosheng Zhang, Shoulong Deng, Xueling Xu, Sujun Wu, Zhimei Liu, Shiyu Qi, Luyu Wang, Yan Li, Kun Yu, Zhengxing Lian (2023). Reproduction and viscera organ characteristics of MSTN and FGF5 dual-gene knockout sheep. Frontiers in veterinary science, 1119312. https://doi.org/10.3389/fvets.2023.1119312 PMID: 37065235",
                    "37065235"
                ],
                [
                    "Alexandrine Mahoudeau, Céline Anquetil, Nozomu Tawara, Hossein Khademian, Damien Amelin, Loïs Bolko, Marco Silvestro, Julian Dal Cin, Bérénice Tendrel, Virginie Tardif, Kubéraka Mariampillai, Gillian Butler-Browne, Olivier Benveniste, Yves Allenbach (2023). Myostatin in idiopathic inflammatory myopathies: Serum assessment and disease activity. Neuropathology and applied neurobiology, e12849. https://doi.org/10.1111/nan.12849 PMID: 36168256",
                    "36168256"
                ],
                [
                    "Jiaye Chen, Tinglin Song, Sizhu Yang, Qingxue Meng, Xiaoyu Han, Ze Wu, Jung-Chien Cheng, Lanlan Fang (2023). Snail mediates GDF-8-stimulated human extravillous trophoblast cell invasion by upregulating MMP2 expression. Cell communication and signaling : CCS, 93. https://doi.org/10.1186/s12964-023-01107-2 PMID: 37143106",
                    "37143106"
                ],
                [
                    "John Lian, Ryan G Walker, Andrea D'Amico, Ana Vujic, Melanie J Mills, Kathleen A Messemer, Kourtney R Mendello, Jill M Goldstein, Krystynne A Leacock, Soraya Epp, Emma V Stimpfl, Thomas B Thompson, Amy J Wagers, Richard T Lee (2023). Functional substitutions of amino acids that differ between GDF11 and GDF8 impact skeletal development and skeletal muscle. Life science alliance. https://doi.org/10.26508/lsa.202201662 PMID: 36631218",
                    "36631218"
                ],
                [
                    "Bor-Rung Ou, Ming-Hua Hsu, Ling-Ya Haung, Chuan-Ju Lin, Li-Li Kuo, Yu-Ting Tsai, Yu-Chia Chang, Wen-Yuh Lin, Tsung-Chien Huang, Yun-Chu Wu, Jan-Ying Yeh, Yu-Chuan Liang (2023). Systematic Myostatin Expression Screening Platform for Identification and Evaluation of Myogenesis-Related Phytogenic in Pigs. Bioengineering (Basel, Switzerland). https://doi.org/10.3390/bioengineering10101113 PMID: 37892843",
                    "37892843"
                ]
            ]
        ],
        [
            [
                "creatine kinase",
                "myostatin"
            ],
            1.0635987,
            [
                [
                    "Hugues Guyot, Damien Legroux, Justine Eppe, Fabrice Bureau, Leah Cannon, Eve Ramery (2024). Hematologic and Serum Biochemical Characteristics of Belgian Blue Cattle. Veterinary sciences. https://doi.org/10.3390/vetsci11050222 PMID: 38787194",
                    "38787194"
                ],
                [
                    "Israel Ramirez-Sanchez, Viridiana Navarrete-Yañez, Lucia Ramirez, Leonor Galera, Enrique Mendez-Bolaina, Veronica Najera, Guillermo Ceballos, Francisco Villarreal (2024). Restorative effects of (+)-epicatechin in a rodent model of aging induced muscle atrophy: underlying mechanisms. Food & function, 3669-3679. https://doi.org/10.1039/d3fo04004f PMID: 38487922",
                    "38487922"
                ],
                [
                    "Nienke M van de Velde, Zaïda Koeks, Mirko Signorelli, Nisha Verwey, Maurice Overzier, Jaap A Bakker, Gautam Sajeev, James Signorovitch, Valeria Ricotti, Jan Verschuuren, Kristy Brown, Pietro Spitali, Erik H Niks (2023). Longitudinal Assessment of Creatine Kinase, Creatine/Creatinineratio, and Myostatin as Monitoring Biomarkers in Becker Muscular Dystrophy. Neurology, e975-e984. https://doi.org/10.1212/WNL.0000000000201609 PMID: 36849458",
                    "36849458"
                ],
                [
                    "Ursula Moore, Esther Fernández-Simón, Marianela Schiava, Dan Cox, Heather Gordish-Dressman, Meredith K James, Anna Mayhew, Ian Wilson, Michela Guglieri, Laura Rufibach, Andrew Blamire, Pierre G Carlier, Madoka Mori-Yoshimura, John W Day, Kristi J Jones, Diana X Bharucha-Goebel, Emmanuelle Salort-Campana, Alan Pestronk, Maggie C Walter, Carmen Paradas, Tanya Stojkovic, Elena Bravver, Elena Pegoraro, Jerry R Mendell, Kate Bushby, Jordi Diaz-Manera, Volker Straub,   (2023). Myostatin and follistatin as monitoring and prognostic biomarkers in dysferlinopathy. Neuromuscular disorders : NMD, 199-207. https://doi.org/10.1016/j.nmd.2023.01.001 PMID: 36689846",
                    "36689846"
                ],
                [
                    "Priyanka Prajapati, Anand Kumar, Jiten Singh, Shubhini A Saraf, Sapana Kushwaha (2023). Azilsartan Ameliorates Skeletal Muscle Wasting in High Fat Diet (HFD)-induced Sarcopenic Obesity in Rats via Activating Akt Signalling Pathway. Archives of gerontology and geriatrics, 105025. https://doi.org/10.1016/j.archger.2023.105025 PMID: 37062187",
                    "37062187"
                ],
                [
                    "Anand Kumar, Priyanka Prajapati, Vinit Raj, Seong-Cheol Kim, Vikas Mishra, Chaitany Jayprakash Raorane, Ritu Raj, Dinesh Kumar, Sapana Kushwaha (2023). Salbutamol ameliorates skeletal muscle wasting and inflammatory markers in streptozotocin (STZ)-induced diabetic rats. International immunopharmacology, 110883. https://doi.org/10.1016/j.intimp.2023.110883 PMID: 37666067",
                    "37666067"
                ],
                [
                    "Matheus Santos de Sousa Fernandes, Jefferson Mariano Gomes, Felipe J Aidar, Mabliny Thuany, Tayrine Ordonio Filgueira, Raphael Fabrício de Souza, Georgian Badicu, Fatma Hilal Yagin, Gianpiero Greco, Stefania Cataldi, Angela Castoldi, Abdullah F Alghannam, Fabrício Oliveira Souto (2023). Impacts of different triathlon races on systemic cytokine profile and metabolic parameters in healthy individuals: a systematic review. BMC sports science, medicine & rehabilitation, 147. https://doi.org/10.1186/s13102-023-00763-8 PMID: 37932804",
                    "37932804"
                ],
                [
                    "Zeinab Noormohammadi, Hana Arghavani, Mohammadhasan Javanbakht, Maryam Daneshpazhooh, Mahmood Jalili (2023). l-carnitine downregulate the muscle wasting effect of glucocorticoids in pemphigus patient: A randomized double-blind placebo-controlled study. Physiological reports, e15657. https://doi.org/10.14814/phy2.15657 PMID: 37078370",
                    "37078370"
                ],
                [
                    "Ismael Bermejo-Álvarez, Sandra Pérez-Baos, Paula Gratal, Juan Pablo Medina, Raquel Largo, Gabriel Herrero-Beaumont, Aránzazu Mediero (2023). Effects of Tofacitinib on Muscle Remodeling in Experimental Rheumatoid Sarcopenia. International journal of molecular sciences. https://doi.org/10.3390/ijms241713181 PMID: 37685986",
                    "37685986"
                ],
                [
                    "Anand Kumar, Priyanka Prajapati, Gurvinder Singh, Dinesh Kumar, Vikas Mishra, Seong-Cheol Kim, Chaitany Jayprakash Raorane, Vinit Raj, Sapana Kushwaha (2023). Salbutamol Attenuates Diabetic Skeletal Muscle Atrophy by Reducing Oxidative Stress, Myostatin/GDF-8, and Pro-Inflammatory Cytokines in Rats. Pharmaceutics. https://doi.org/10.3390/pharmaceutics15082101 PMID: 37631314",
                    "37631314"
                ]
            ]
        ],
        [
            [
                "UTRN",
                "Muscular Dystrophy, Duchenne"
            ],
            4.6754475,
            [
                [
                    "Christine Péladeau, Nadine Adam, Lucas M Bronicki, Adèle Coriati, Mohamed Thabet, Hasanen Al-Rewashdy, Jason Vanstone, Alan Mears, Jean-Marc Renaud, Martin Holcik, Bernard J Jasmin (2020). Identification of therapeutics that target eEF1A2 and upregulate utrophin A translation in dystrophic muscles. Nature communications, 1990. https://doi.org/10.1038/s41467-020-15971-w PMID: 32332749",
                    "32332749"
                ],
                [
                    "Maria Razzoli, Angus Lindsay, Michelle L Law, Christopher M Chamberlain, William M Southern, Madeleine Berg, John Osborn, William C Engeland, Joseph M Metzger, James M Ervasti, Alessandro Bartolomucci (2020). Social stress is lethal in the mdx model of Duchenne muscular dystrophy. EBioMedicine, 102700. https://doi.org/10.1016/j.ebiom.2020.102700 PMID: 32192914",
                    "32192914"
                ],
                [
                    "Claire L Wood, Karla J Suchacki, Rob van 't Hof, Will P Cawthorn, Scott Dillon, Volker Straub, Sze Choong Wong, Syed F Ahmed, Colin Farquharson (2020). A comparison of the bone and growth phenotype of mdx, mdx:Cmah and mdx:Utrn murine models with the C57BL/10 wild-type mouse. Disease models & mechanisms. https://doi.org/10.1242/dmm.040659 PMID: 31754018",
                    "31754018"
                ],
                [
                    "Glen B Banks, Jeffrey S Chamberlain, Guy L Odom (2020). Microutrophin expression in dystrophic mice displays myofiber type differences in therapeutic effects. PLoS genetics, e1009179. https://doi.org/10.1371/journal.pgen.1009179 PMID: 33175853",
                    "33175853"
                ],
                [
                    "Maaike van Putten, Christa Tanganyika-de Winter, Sieto Bosgra, Annemieke Aartsma-Rus (2019). Nonclinical Exon Skipping Studies with 2'-O-Methyl Phosphorothioate Antisense Oligonucleotides in mdx and mdx-utrn-/- Mice Inspired by Clinical Trial Results. Nucleic acid therapeutics, 92-103. https://doi.org/10.1089/nat.2018.0759 PMID: 30672725",
                    "30672725"
                ],
                [
                    "Cinzia Pisani, Georgios Strimpakos, Francesca Gabanella, Maria Grazia Di Certo, Annalisa Onori, Cinzia Severini, Siro Luvisetto, Stefano Farioli-Vecchioli, Irene Carrozzo, Antonio Esposito, Tamara Canu, Elisabetta Mattei, Nicoletta Corbi, Claudio Passananti (2018). Utrophin up-regulation by artificial transcription factors induces muscle rescue and impacts the neuromuscular junction in mdx mice. Biochimica et biophysica acta. Molecular basis of disease, 1172-1182. https://doi.org/10.1016/j.bbadis.2018.01.030 PMID: 29408646",
                    "29408646"
                ],
                [
                    "Christine Péladeau, Nadine J Adam, Bernard J Jasmin (2018). Celecoxib treatment improves muscle function in mdx mice and increases utrophin A expression. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 5090-5103. https://doi.org/10.1096/fj.201800081R PMID: 29723037",
                    "29723037"
                ],
                [
                    "Antoine Boulanger Piette, Dounia Hamoudi, Laetitia Marcadet, Frédérique Kyomi Labelle, Rares Ovidiu David, Sabrina Bossé, Anteneh Argaw, Jérôme Frenette (2018). Utrophin haploinsufficiency does not worsen the functional performance, resistance to eccentric contractions and force production of dystrophic mice. PloS one, e0198408. https://doi.org/10.1371/journal.pone.0198408 PMID: 29879154",
                    "29879154"
                ],
                [
                    "Kelly J Perkins, Kay E Davies (2018). Alternative utrophin mRNAs contribute to phenotypic differences between dystrophin-deficient mice and Duchenne muscular dystrophy. FEBS letters, 1856-1869. https://doi.org/10.1002/1873-3468.13099 PMID: 29772070",
                    "29772070"
                ],
                [
                    "Adel Amirouche, Vanessa E Jahnke, John A Lunde, Nathalie Koulmann, Damien G Freyssenet, Bernard J Jasmin (2017). Muscle-specific microRNA-206 targets multiple components in dystrophic skeletal muscle representing beneficial adaptations. American journal of physiology. Cell physiology, C209-C221. https://doi.org/10.1152/ajpcell.00185.2016 PMID: 28003225",
                    "28003225"
                ]
            ]
        ],
        [
            [
                "creatine kinase",
                "TGFB1"
            ],
            0.7260498999999999,
            [
                [
                    "Shinji Izuka, Natsuka Umezawa, Toshihiko Komai, Yusuke Sugimori, Naoki Kimura, Fumitaka Mizoguchi, Yuichiro Fujieda, Keita Ninagawa, Takeshi Iwasaki, Katsuya Suzuki, Tsutomu Takeuchi, Koichiro Ohmura, Tsuneyo Mimori, Tatsuya Atsumi, Eiryo Kawakami, Akari Suzuki, Yuta Kochi, Kazuhiko Yamamoto, Shinsuke Yasuda, Tomohisa Okamura, Mineto Ota, Keishi Fujio (2025). Muscle Tissue Transcriptome of Idiopathic Inflammatory Myopathy Reflects the Muscle Damage Process by Monocytes and Presence of Skin Lesions. Arthritis & rheumatology (Hoboken, N.J.), 99-106. https://doi.org/10.1002/art.42972 PMID: 39162115",
                    "39162115"
                ],
                [
                    "Mu Guo, Xiangbin Yu, Zesheng Yang, Hanlu Zheng, Jiahui Zhang, Junxiang Wang, Yiqi Liao, Weirui Huang, Zhaolong Lin, Yingxue Yan, Nengfu Qiu, Jianmin Chen, Yue Yu (2024). Levamisole Ameliorates Rheumatoid Arthritis by Downregulating the PI3K/Akt Pathway in SD Rats. Pharmaceuticals (Basel, Switzerland). https://doi.org/10.3390/ph17111504 PMID: 39598415",
                    "39598415"
                ],
                [
                    "Xiaodan Lu, Fuyao Liu, Hongming Chen, Haojie Cai, Lei Zhang, Jing Li (2024). Effects of WN1703 on Cardiovascular Function in Chronic Hyperuricemia Rats and Myocardial Injury Mechanism Exploration in H9C2 Cells. Journal of applied toxicology : JAT. https://doi.org/10.1002/jat.4710 PMID: 39435646",
                    "39435646"
                ],
                [
                    "Xiao-Jing Li, Li-Rong Wang, Bing Jiang, Chun-Zhen Ren, Xin-Fang Lyu, Xue Wu, Hui-Lin Zhao, Xin-Ke Zhao, Ying-Dong Li (2024). [Effects of Luhong Yixin Granules on myocardial fibrosis in heart failure rats based on TGF-β1/Smads signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 3583-3590. https://doi.org/10.19540/j.cnki.cjcmm.20240308.401 PMID: 39041130",
                    "39041130"
                ],
                [
                    "Panpan Zhao, Yan Wang, Qiankun Yang, Guili Yu, Fenfen Ma, Jingquan Dong (2023). Abamectin causes cardiac dysfunction in carp via inhibiting redox equilibrium and resulting in immune inflammatory response and programmed cell death. Environmental science and pollution research international, 29494-29509. https://doi.org/10.1007/s11356-022-24004-6 PMID: 36418824",
                    "36418824"
                ],
                [
                    "J Li, Y Ma, L Zhang, C Cai, Y Guo, Z Zhang, D Li, Y Tian, X Kang, R Han, R Jiang (2023). Valgus-varus deformity induced abnormal tissue metabolism, inflammatory damage and apoptosis in broilers. British poultry science, 26-35. https://doi.org/10.1080/00071668.2022.2121640 PMID: 36102935",
                    "36102935"
                ],
                [
                    "Ying Tang, Li Shen, Jing-Hui Bao, Dan-Yan Xu (2023). Deficiency of Tregs in hypertension-associated left ventricular hypertrophy. Journal of clinical hypertension (Greenwich, Conn.), 562-572. https://doi.org/10.1111/jch.14660 PMID: 37196041",
                    "37196041"
                ],
                [
                    "Baoshi Xu, Jilei Yin, Jingchao Qiang, Jiajie Gan, Xuhui Xu, Xing Li, Zunhan Hu, Zibo Dong (2023). Quercetin attenuates avermectin-induced cardiac injury in carp through inflammation, oxidative stress, apoptosis and autophagy. Fish & shellfish immunology, 109054. https://doi.org/10.1016/j.fsi.2023.109054 PMID: 37661034",
                    "37661034"
                ],
                [
                    "Ha Rim Shin, Eun-Ji Ko, Yun-Jeong Kang, Hak-Sun Yu, Mee Sun Ock, Hee-Jae Cha (2023). Effect of parasitic infection on muscular function of dystrophin gene (Dmd) deficient mouse. Genes & genomics, 183-190. https://doi.org/10.1007/s13258-022-01355-5 PMID: 36571712",
                    "36571712"
                ],
                [
                    "Xin-Yi Fan, Xiao-Qi Wei, Yun-Yang Zhang, Hai-Yin Pu, Fang-He Li, Kuo Gao, Xue Yu, Shu-Zhen Guo (2023). [Effect and mechanism of Jiming Powder on myocardial fibrosis in mice with myocardial infarction]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 5838-5850. https://doi.org/10.19540/j.cnki.cjcmm.20230605.401 PMID: 38114180",
                    "38114180"
                ]
            ]
        ],
        [
            [
                "UTRN",
                "TGFB1"
            ],
            0.7260498999999999,
            [
                [
                    "Zhouguang Wu, Bin Wang, Siqi Chen, Taoyan Zuo, Wenjie Zhang, Zhen Cheng, Jingru Fu, Jiafeng Gong (2024). Hsa_circ_0009096/miR-370-3p modulates hepatic stellate cell proliferation and fibrosis during biliary atresia pathogenesis. PeerJ, e17356. https://doi.org/10.7717/peerj.17356 PMID: 38766485",
                    "38766485"
                ],
                [
                    "Christopher Ballmann, Thomas S Denney, Ronald J Beyers, Tiffany Quindry, Matthew Romero, Rajesh Amin, Joshua T Selsby, John C Quindry (2017). Lifelong quercetin enrichment and cardioprotection in Mdx/Utrn+/- mice. American journal of physiology. Heart and circulatory physiology, H128-H140. https://doi.org/10.1152/ajpheart.00552.2016 PMID: 27836895",
                    "27836895"
                ]
            ]
        ],
        [
            [
                "Muscular Dystrophy, Duchenne",
                "MSTN"
            ],
            0.034735254,
            [
                [
                    "Dong Kyung Sung, Hyeongseop Kim, Sang Eon Park, Jiwon Lee, Ju-A Kim, Young-Chul Park, Hong Bae Jeon, Jong Wook Chang, Jeehun Lee (2022). A New Method of Myostatin Inhibition in Mice via Oral Administration of Lactobacillus casei Expressing Modified Myostatin Protein, BLS-M22. International journal of molecular sciences. https://doi.org/10.3390/ijms23169059 PMID: 36012334",
                    "36012334"
                ],
                [
                    "Se-Youl Chae, Euihwan Jeong, Seounghun Kang, Yeajee Yim, Jin-Soo Kim, Dal-Hee Min (2022). Rationally designed nanoparticle delivery of Cas9 ribonucleoprotein for effective gene editing. Journal of controlled release : official journal of the Controlled Release Society, 108-119. https://doi.org/10.1016/j.jconrel.2022.02.035 PMID: 35247491",
                    "35247491"
                ],
                [
                    "Zeren Sun, Dengqiu Xu, Lei Zhao, Xihua Li, Sijia Li, Xiaofei Huang, Chunjie Li, Lixin Sun, Bing Liu, Zhenzhou Jiang, Luyong Zhang (2022). A new therapeutic effect of fenofibrate in Duchenne muscular dystrophy: The promotion of myostatin degradation. British journal of pharmacology, 1237-1250. https://doi.org/10.1111/bph.15678 PMID: 34553378",
                    "34553378"
                ],
                [
                    "David W Hammers, Cora C Hart, Andreas Patsalos, Michael K Matheny, Lillian A Wright, Laszlo Nagy, H Lee Sweeney (2020). Glucocorticoids counteract hypertrophic effects of myostatin inhibition in dystrophic muscle. JCI insight. PMID: 31830002",
                    "31830002"
                ],
                [
                    "Virginie Mariot, Caroline Le Guiner, Inès Barthélémy, Marie Montus, Stéphane Blot, Silvia Torelli, Jennifer Morgan, Francesco Muntoni, Thomas Voit, Julie Dumonceaux (2020). Myostatin Is a Quantifiable Biomarker for Monitoring Pharmaco-gene Therapy in Duchenne Muscular Dystrophy. Molecular therapy. Methods & clinical development, 415-421. https://doi.org/10.1016/j.omtm.2020.06.016 PMID: 32695843",
                    "32695843"
                ],
                [
                    "Emma Rybalka, Cara A Timpani, Danielle A Debruin, Ryan M Bagaric, Dean G Campelj, Alan Hayes (2020). The Failed Clinical Story of Myostatin Inhibitors against Duchenne Muscular Dystrophy: Exploring the Biology behind the Battle. Cells. https://doi.org/10.3390/cells9122657 PMID: 33322031",
                    "33322031"
                ],
                [
                    "Hoa Q Nguyen, Andrea Iskenderian, David Ehmann, Paul Jasper, Zhiwei Zhang, Haojing Rong, Devin Welty, Rangaraj Narayanan (2020). Leveraging Quantitative Systems Pharmacology Approach into Development of Human Recombinant Follistatin Fusion Protein for Duchenne Muscular Dystrophy. CPT: pharmacometrics & systems pharmacology, 342-352. https://doi.org/10.1002/psp4.12518 PMID: 32419339",
                    "32419339"
                ],
                [
                    "Yeonhee Hong, Jong Han Lee, Kwang Won Jeong, Cheol Soo Choi, Hee-Sook Jun (2019). Amelioration of muscle wasting by glucagon-like peptide-1 receptor agonist in muscle atrophy. Journal of cachexia, sarcopenia and muscle, 903-918. https://doi.org/10.1002/jcsm.12434 PMID: 31020810",
                    "31020810"
                ],
                [
                    "R S Pearsall, M V Davies, M Cannell, J Li, J Widrick, A W Mulivor, S Wallner, M E Troy, M Spaits, K Liharska, D Sako, R Castonguay, S Keates, A V Grinberg, R N V S Suragani, R Kumar (2019). Follistatin-based ligand trap ACE-083 induces localized hypertrophy of skeletal muscle with functional improvement in models of neuromuscular disease. Scientific reports, 11392. https://doi.org/10.1038/s41598-019-47818-w PMID: 31388039",
                    "31388039"
                ],
                [
                    "Quan Jin, Chunping Qiao, Jianbin Li, Bin Xiao, Juan Li, Xiao Xiao (2019). A GDF11/myostatin inhibitor, GDF11 propeptide-Fc, increases skeletal muscle mass and improves muscle strength in dystrophic mdx mice. Skeletal muscle, 16. https://doi.org/10.1186/s13395-019-0197-y PMID: 31133057",
                    "31133057"
                ]
            ]
        ],
        [
            [
                "Muscular Dystrophy, Duchenne",
                "HDAC"
            ],
            0.015828688,
            [
                [
                    "Chiara Mozzetta, Vittorio Sartorelli, Christian Steinkuhler, Pier Lorenzo Puri (2024). HDAC inhibitors as pharmacological treatment for Duchenne muscular dystrophy: a discovery journey from bench to patients. Trends in molecular medicine, 278-294. https://doi.org/10.1016/j.molmed.2024.01.007 PMID: 38408879",
                    "38408879"
                ],
                [
                    "Chiara Mozzetta, Vittorio Sartorelli, Christian Steinkuhler, Pier Lorenzo Puri (2024). HDAC inhibitors as pharmacological treatment for Duchenne muscular dystrophy: a discovery journey from bench to patients: (Trends in Molecular Medicine, 30:3 p:278-294, 2024). Trends in molecular medicine, 698. https://doi.org/10.1016/j.molmed.2024.03.012 PMID: 38643051",
                    "38643051"
                ],
                [
                    "Asher Mullard (2024). FDA approves an HDAC inhibitor for Duchenne muscular dystrophy. Nature reviews. Drug discovery, 329. https://doi.org/10.1038/d41573-024-00066-8 PMID: 38605117",
                    "38605117"
                ],
                [
                    "Maria A Theodoropoulou, Christiana Mantzourani, George Kokotos (2024). Histone Deacetylase (HDAC) Inhibitors as a Novel Therapeutic Option Against Fibrotic and Inflammatory Diseases. Biomolecules. https://doi.org/10.3390/biom14121605 PMID: 39766311",
                    "39766311"
                ],
                [
                    "Brigida Boccanegra, Paola Mantuano, Elena Conte, Alessandro Giovanni Cerchiara, Lisamaura Tulimiero, Raffaella Quarta, Erika Caputo, Francesca Sanarica, Monica Forino, Valeria Spadotto, Ornella Cappellari, Gianluca Fossati, Christian Steinkühler, Annamaria De Luca (2023). LKB1 signaling is altered in skeletal muscle of a Duchenne muscular dystrophy mouse model. Disease models & mechanisms. https://doi.org/10.1242/dmm.049930 PMID: 37427454",
                    "37427454"
                ],
                [
                    "Martina Sandonà, Giorgia Cavioli, Alessandra Renzini, Alessia Cedola, Giuseppe Gigli, Dario Coletti, Timothy A McKinsey, Viviana Moresi, Valentina Saccone (2023). Histone Deacetylases: Molecular Mechanisms and Therapeutic Implications for Muscular Dystrophies. International journal of molecular sciences. https://doi.org/10.3390/ijms24054306 PMID: 36901738",
                    "36901738"
                ],
                [
                    "Yasir S Raouf, Abootaleb Sedighi, Mulu Geletu, Geordon A Frere, Rebecca G Allan, Nabanita Nawar, Elvin D de Araujo, Patrick T Gunning (2023). Discovery of YSR734: A Covalent HDAC Inhibitor with Cellular Activity in Acute Myeloid Leukemia and Duchenne Muscular Dystrophy. Journal of medicinal chemistry. https://doi.org/10.1021/acs.jmedchem.3c01236 PMID: 38060537",
                    "38060537"
                ],
                [
                    "Suresh C Tyagi, Sathnur Pushpakumar, Utpal Sen, Sri Prakash L Mokshagundam, Dinesh K Kalra, Mohamed A Saad, Mahavir Singh (2022). COVID-19 Mimics Pulmonary Dysfunction in Muscular Dystrophy as a Post-Acute Syndrome in Patients. International journal of molecular sciences. https://doi.org/10.3390/ijms24010287 PMID: 36613731",
                    "36613731"
                ],
                [
                    "Silvia Consalvi, Luca Tucciarone, Elisa Macrì, Marco De Bardi, Mario Picozza, Illari Salvatori, Alessandra Renzini, Sergio Valente, Antonello Mai, Viviana Moresi, Pier Lorenzo Puri (2022). Determinants of epigenetic resistance to HDAC inhibitors in dystrophic fibro-adipogenic progenitors. EMBO reports, e54721. https://doi.org/10.15252/embr.202254721 PMID: 35383427",
                    "35383427"
                ],
                [
                    "Alessandra Renzini, Nicoletta Marroncelli, Giorgia Cavioli, Silvia Di Francescantonio, Laura Forcina, Alessandro Lambridis, Eros Di Giorgio, Sergio Valente, Antonello Mai, Claudio Brancolini, Claudia Giampietri, Alessandra Magenta, Francesca De Santa, Sergio Adamo, Dario Coletti, Viviana Moresi (2022). Cytoplasmic HDAC4 regulates the membrane repair mechanism in Duchenne muscular dystrophy. Journal of cachexia, sarcopenia and muscle, 1339-1359. https://doi.org/10.1002/jcsm.12891 PMID: 35170869",
                    "35170869"
                ]
            ]
        ],
        [
            [
                "creatine kinase",
                "MSTN"
            ],
            1.1798203999999999,
            [
                [
                    "Ismael Bermejo-Álvarez, Sandra Pérez-Baos, Paula Gratal, Juan Pablo Medina, Raquel Largo, Gabriel Herrero-Beaumont, Aránzazu Mediero (2023). Effects of Tofacitinib on Muscle Remodeling in Experimental Rheumatoid Sarcopenia. International journal of molecular sciences. https://doi.org/10.3390/ijms241713181 PMID: 37685986",
                    "37685986"
                ],
                [
                    "Dong Kyung Sung, Hyeongseop Kim, Sang Eon Park, Jiwon Lee, Ju-A Kim, Young-Chul Park, Hong Bae Jeon, Jong Wook Chang, Jeehun Lee (2022). A New Method of Myostatin Inhibition in Mice via Oral Administration of Lactobacillus casei Expressing Modified Myostatin Protein, BLS-M22. International journal of molecular sciences. https://doi.org/10.3390/ijms23169059 PMID: 36012334",
                    "36012334"
                ],
                [
                    "Theodoros Alexopoulos, Larisa Vasilieva, Meropi D Kontogianni, Roxane Tenta, Alexandra Georgiou, Evangelia Stroumpouli, Iliana Mani, Alexandra Alexopoulou (2021). Myostatin in combination with creatine phosphokinase or albumin may differentiate patients with cirrhosis and sarcopenia. American journal of physiology. Gastrointestinal and liver physiology, G543-G551. https://doi.org/10.1152/ajpgi.00184.2021 PMID: 34469188",
                    "34469188"
                ],
                [
                    "Jooyoung Kim, Kwanghoon Park, Joohyung Lee (2020). Myostatin A55T Genotype is Associated with Strength Recovery Following Exercise-Induced Muscle Damage. International journal of environmental research and public health. https://doi.org/10.3390/ijerph17134900 PMID: 32645967",
                    "32645967"
                ],
                [
                    "Quan Jin, Chunping Qiao, Jianbin Li, Bin Xiao, Juan Li, Xiao Xiao (2019). A GDF11/myostatin inhibitor, GDF11 propeptide-Fc, increases skeletal muscle mass and improves muscle strength in dystrophic mdx mice. Skeletal muscle, 16. https://doi.org/10.1186/s13395-019-0197-y PMID: 31133057",
                    "31133057"
                ],
                [
                    "Mette Flindt Heisterberg, Jesper L Andersen, Peter Schjerling, Jacob Bülow, Jeppe Bo Lauersen, Heidi L Roeber, Michael Kjaer, Abigail L Mackey (2018). Effect of Losartan on the Acute Response of Human Elderly Skeletal Muscle to Exercise. Medicine and science in sports and exercise, 225-235. https://doi.org/10.1249/MSS.0000000000001438 PMID: 29040223",
                    "29040223"
                ],
                [
                    "Mika Ohta, Yoichiroh Hosokawa, Naoya Hatano, Aki Sugano, Akihiko Ito, Yutaka Takaoka (2017). Efficacy of femtosecond lasers for application of acupuncture therapy. Lasers in medical science, 2167-2171. https://doi.org/10.1007/s10103-016-2124-3 PMID: 27942989",
                    "27942989"
                ],
                [
                    "Cleber Ferraresi, Danilo Bertucci, Josiane Schiavinato, Rodrigo Reiff, Amélia Araújo, Rodrigo Panepucci, Euclides Matheucci, Anderson Ferreira Cunha, Vivian Maria Arakelian, Michael R Hamblin, Nivaldo Parizotto, Vanderlei Bagnato (2016). Effects of Light-Emitting Diode Therapy on Muscle Hypertrophy, Gene Expression, Performance, Damage, and Delayed-Onset Muscle Soreness: Case-control Study with a Pair of Identical Twins. American journal of physical medicine & rehabilitation, 746-57. https://doi.org/10.1097/PHM.0000000000000490 PMID: 27088469",
                    "27088469"
                ],
                [
                    "Vural Kesik, Tevfik Honca, Mustafa Gulgun, Bulent Uysal, Yasemin Gulcan Kurt, Tuncer Cayci, Oguzhan Babacan, Ercan Gocgeldi, Nadir Korkmazer (2016). Myostatin as a Marker for Doxorubicin Induced Cardiac Damage. Annals of clinical and laboratory science, 26-31. PMID: 26927339",
                    "26927339"
                ],
                [
                    "Yin-Hsiu Chien, Der-Sheng Han, Wuh-Liang Hwu, Beth L Thurberg, Wei-Shiung Yang (2013). Myostatin and insulin-like growth factor I: potential therapeutic biomarkers for pompe disease. PloS one, e71900. https://doi.org/10.1371/journal.pone.0071900 PMID: 23967261",
                    "23967261"
                ]
            ]
        ],
        [
            [
                "creatine kinase",
                "Transforming Growth Factor beta"
            ],
            0.6583711,
            [
                [
                    "Lei Li, Annamalai Vijayalakshmi (2023). Protective effect of Pueraria lobata leaves on doxorubicin-induced myocardial infarction in experimental Wistar rats. Biotechnology and applied biochemistry, 1641-1651. https://doi.org/10.1002/bab.2462 PMID: 36950801",
                    "36950801"
                ],
                [
                    "Won Kil Lee, Yeongyeong Kim, Heejin Jang, Joo Hye Sim, Hye Jin Choi, Younmin Shin, Jeong June Choi (2021). Exogenous Transforming Growth Factor-β in Brain-Induced Symptoms of Central Fatigue and Suppressed Dopamine Production in Mice. International journal of molecular sciences. https://doi.org/10.3390/ijms22052580 PMID: 33806649",
                    "33806649"
                ],
                [
                    "Dili Xie, Min Li, Kang Yu, Hua Lu, Yong Chen (2020). Etomidate alleviates cardiac dysfunction, fibrosis and oxidative stress in rats with myocardial ischemic reperfusion injury. Annals of translational medicine, 1181. https://doi.org/10.21037/atm-20-6015 PMID: 33241030",
                    "33241030"
                ],
                [
                    "Ramsha Iqbal, Md Sayeed Akhtar, Md Quamrul Hassan, Zeeba Jairajpuri, Mohd Akhtar, Abul Kalam Najmi (2019). Pitavastatin ameliorates myocardial damage by preventing inflammation and collagen deposition via reduced free radical generation in isoproterenol-induced cardiomyopathy. Clinical and experimental hypertension (New York, N.Y. : 1993), 434-443. https://doi.org/10.1080/10641963.2018.1501059 PMID: 30192645",
                    "30192645"
                ],
                [
                    "Yasemin Tekşen, Emine Kadıoğlu, Cengiz Koçak, Havva Koçak (2019). Effect of Hydrogen Sulfide on Kidney Injury in Rat Model of Crush Syndrome. The Journal of surgical research, 470-478. https://doi.org/10.1016/j.jss.2018.10.033 PMID: 30691831",
                    "30691831"
                ],
                [
                    "Lenice Kappes Becker, Nádia Lúcia Totou, Mariana Flávia Oliveira, Daniel Barbosa Coelho, Emerson Cruz de Oliveira, Daisy Motta-Santos, Emerson Silami-Garcia, Maria José Campagnole-Santos, Robson Augusto Souza Santos (2019). Lifetime overproduction of circulating angiotensin-(1-7) in rats attenuates the increase in skeletal muscle damage biomarkers after exhaustive exercise. The Chinese journal of physiology, 226-230. https://doi.org/10.4103/CJP.CJP_57_19 PMID: 31670287",
                    "31670287"
                ],
                [
                    "Keren Turjeman, Nurit Yanay, Moran Elbaz, Yaelle Bavli, Moria Gross, Malcolm Rabie, Yechezkel Barenholz, Yoram Nevo (2019). Liposomal steroid nano-drug is superior to steroids as-is in mdx mouse model of Duchenne muscular dystrophy. Nanomedicine : nanotechnology, biology, and medicine, 34-44. https://doi.org/10.1016/j.nano.2018.11.012 PMID: 30529791",
                    "30529791"
                ],
                [
                    "Ariel Bier, Peter Berenstein, Noam Kronfeld, Daria Morgoulis, Amotz Ziv-Av, Hodaya Goldstein, Gila Kazimirsky, Simona Cazacu, Rinat Meir, Rachela Popovtzer, Amir Dori, Chaya Brodie (2018). Placenta-derived mesenchymal stromal cells and their exosomes exert therapeutic effects in Duchenne muscular dystrophy. Biomaterials, 67-78. https://doi.org/10.1016/j.biomaterials.2018.04.055 PMID: 29783118",
                    "29783118"
                ],
                [
                    "Samara Camaçari de Carvalho, Cintia Yuri Matsumura, Humberto Santo Neto, Maria Julia Marques (2018). Identification of plasma interleukins as biomarkers for deflazacort and omega-3 based Duchenne muscular dystrophy therapy. Cytokine, 55-61. https://doi.org/10.1016/j.cyto.2017.12.006 PMID: 29276972",
                    "29276972"
                ],
                [
                    "Yanping Li, Ya Zhang, Min Wen, Ju Zhang, Xia Zhao, Yuan Zhao, Jiagang Deng (2017). Ginkgo biloba extract prevents acute myocardial infarction and suppresses the inflammation‑ and apoptosis‑regulating p38 mitogen‑activated protein kinases, nuclear factor‑κB and B‑cell lymphoma 2 signaling pathways. Molecular medicine reports, 3657-3663. https://doi.org/10.3892/mmr.2017.6999 PMID: 28713946",
                    "28713946"
                ]
            ]
        ],
        [
            [
                "UTRN",
                "Transforming Growth Factor beta"
            ],
            0.6583711,
            [
                [
                    "Zhouguang Wu, Bin Wang, Siqi Chen, Taoyan Zuo, Wenjie Zhang, Zhen Cheng, Jingru Fu, Jiafeng Gong (2024). Hsa_circ_0009096/miR-370-3p modulates hepatic stellate cell proliferation and fibrosis during biliary atresia pathogenesis. PeerJ, e17356. https://doi.org/10.7717/peerj.17356 PMID: 38766485",
                    "38766485"
                ],
                [
                    "Robin N Michel, Eva R Chin, Joe V Chakkalakal, Joe K Eibl, Bernard J Jasmin (2007). Ca2+/calmodulin-based signalling in the regulation of the muscle fibre phenotype and its therapeutic potential via modulation of utrophin A and myostatin expression. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 921-9. https://doi.org/10.1139/H07-093 PMID: 18059617",
                    "18059617"
                ]
            ]
        ],
        [
            [
                "Muscular Dystrophy, Duchenne",
                "dystrophin"
            ],
            3.3688149999999997,
            [
                [
                    "Marie E Esper, Caroline E Brun, Alexander Y T Lin, Peter Feige, Marie J Catenacci, Marie-Claude Sincennes, Morten Ritso, Michael A Rudnicki (2025). Intrinsic Muscle Stem Cell Dysfunction Contributes to Impaired Regeneration in the mdx Mouse. Journal of cachexia, sarcopenia and muscle, e13682. https://doi.org/10.1002/jcsm.13682 PMID: 39723578",
                    "39723578"
                ],
                [
                    "Rebecca A Slick, Jessica Sutton, Margaret Haberman, Benjamin S O'Brien, Jennifer A Tinklenberg, Aashay Mardikar, Mariah J Prom, Margaret Beatka, Melanie Gartz, Mark A Vanden Avond, Emily Siebers, David L Mack, J Patrick Gonzalez, Allison D Ebert, Kanneboyina Nagaraju, Michael W Lawlor (2024). High mobility group box 1 (HMGB1) is a potential disease biomarker in cell and mouse models of Duchenne muscular dystrophy. Biology open. https://doi.org/10.1242/bio.060542 PMID: 39158383",
                    "39158383"
                ],
                [
                    "David M Rind (2024). The FDA and Gene Therapy for Duchenne Muscular Dystrophy. JAMA, 1705-1706. https://doi.org/10.1001/jama.2024.5613 PMID: 38691382",
                    "38691382"
                ],
                [
                    "Vahid Omarmeli, Kai-Uwe Lewandrowski, Marjan Assefi, Hanieh Faizmahdavi, Alireza Sharafshah, Nasrin Mansouri (2024). A Novel Mutation (Lys31Arg) in the DMD Gene Impacts on Neuromuscular Dysfunctions Found by Whole Exome Sequencing and In Silico Analyses in an Iranian Family. Current aging science, 169-174. https://doi.org/10.2174/0118746098280408240112112414 PMID: 38265407",
                    "38265407"
                ],
                [
                    "Nalaka Wijekoon, Lakmal Gonawala, Pyara Ratnayake, Pulasthi Dissanayaka, Isuru Gunarathne, Dhammika Amaratunga, Roshan Liyanage, Sunethra Senanayaka, Saraji Wijesekara, Hemal H Gunasekara, Kamala Vanarsa, Jessica Castillo, Yetrib Hathout, Ashwin Dalal, Harry W M Steinbusch, Eric Hoffman, Chandra Mohan, K Ranil D de Silva (2023). Integrated genomic, proteomic and cognitive assessment in Duchenne Muscular Dystrophy suggest astrocyte centric pathology. Heliyon, e18530. https://doi.org/10.1016/j.heliyon.2023.e18530 PMID: 37593636",
                    "37593636"
                ],
                [
                    "Merry He, Toshifumi Yokota (2023). Exons 45-55 Skipping Using Antisense Oligonucleotides in Immortalized Human DMD Muscle Cells. Methods in molecular biology (Clifton, N.J.), 313-325. https://doi.org/10.1007/978-1-0716-3036-5_22 PMID: 36995604",
                    "36995604"
                ],
                [
                    "Narin Sheri, Toshifumi Yokota (2023). In Vivo Evaluation of Exon 51 Skipping in hDMD/Dmd-null Mice. Methods in molecular biology (Clifton, N.J.), 327-336. https://doi.org/10.1007/978-1-0716-3036-5_23 PMID: 36995605",
                    "36995605"
                ],
                [
                    "Katsuyuki Nakamura, Takao Tanaka, Keitaro Yamanouchi (2023). In Vivo Modeling of Skeletal Muscle Diseases Using the CRISPR/Cas9 System in Rats. Methods in molecular biology (Clifton, N.J.), 277-285. https://doi.org/10.1007/978-1-0716-3036-5_20 PMID: 36995602",
                    "36995602"
                ],
                [
                    "Remko Goossens, Nisha Verwey, Yavuz Ariyurek, Fred Schnell, Annemieke Aartsma-Rus (2023). DMD antisense oligonucleotide mediated exon skipping efficiency correlates with flanking intron retention time and target position within the exon. RNA biology, 693-702. https://doi.org/10.1080/15476286.2023.2254041 PMID: 37667454",
                    "37667454"
                ],
                [
                    "Viktorija Cernisova, Ngoc Lu-Nguyen, Jessica Trundle, Shan Herath, Alberto Malerba, Linda Popplewell (2023). Microdystrophin Gene Addition Significantly Improves Muscle Functionality and Diaphragm Muscle Histopathology in a Fibrotic Mouse Model of Duchenne Muscular Dystrophy. International journal of molecular sciences. https://doi.org/10.3390/ijms24098174 PMID: 37175881",
                    "37175881"
                ]
            ]
        ],
        [
            [
                "UTRN",
                "MSTN"
            ],
            1.1798203999999999,
            [
                [
                    "Robin N Michel, Eva R Chin, Joe V Chakkalakal, Joe K Eibl, Bernard J Jasmin (2007). Ca2+/calmodulin-based signalling in the regulation of the muscle fibre phenotype and its therapeutic potential via modulation of utrophin A and myostatin expression. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 921-9. https://doi.org/10.1139/H07-093 PMID: 18059617",
                    "18059617"
                ]
            ]
        ],
        [
            [
                "DMD",
                "myostatin"
            ],
            1.0635987,
            [
                [
                    "Jerry R Mendell, Zarife Sahenk, Vinod Malik, Ana M Gomez, Kevin M Flanigan, Linda P Lowes, Lindsay N Alfano, Katherine Berry, Eric Meadows, Sarah Lewis, Lyndsey Braun, Kim Shontz, Maria Rouhana, Kelly Reed Clark, Xiomara Q Rosales, Samiah Al-Zaidy, Alessandra Govoni, Louise R Rodino-Klapac, Mark J Hogan, Brian K Kaspar (2015). A phase 1/2a follistatin gene therapy trial for becker muscular dystrophy. Molecular therapy : the journal of the American Society of Gene Therapy, 192-201. https://doi.org/10.1038/mt.2014.200 PMID: 25322757",
                    "25322757"
                ],
                [
                    "Joe V Chakkalakal, Jennifer Thompson, Robin J Parks, Bernard J Jasmin (2005). Molecular, cellular, and pharmacological therapies for Duchenne/Becker muscular dystrophies. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 880-91. https://doi.org/10.1096/fj.04-1956rev PMID: 15923398",
                    "15923398"
                ]
            ]
        ],
        [
            [
                "dystrophin",
                "DMD"
            ],
            4.1355435,
            [
                [
                    "Harunobu Muto, Yoshihiko Yu, James K Chambers, Lyndon M Coghill, Yasuharu Nakamura, Kazuyuki Uchida, Leslie A Lyons (2024). Association of a novel dystrophin (DMD) genetic nonsense variant in a cat with X-linked muscular dystrophy with a mild clinical course. Journal of veterinary internal medicine, 1160-1166. https://doi.org/10.1111/jvim.17024 PMID: 38415938",
                    "38415938"
                ],
                [
                    "Yan Wang, Yan Sun, Lulu Meng, Quanze He, Jingyu Zhao, Ran Zhou, Zhonghua Wang, Jianxin Tan, Dingyuan Ma, Linlin Fan, Yunmei Chen, Yuguo Wang, Zhu Jiang, Zhihong Qiao, Xiaojuan Wu, Binbin Shao, Ying Xue, Lijie Song, Ting Wang, Ping Hu, Zhengfeng Xu (2024). A new strategy for prenatal genetic screening of copy number variations in the DMD gene: A large cohort study based on NIPT analysis. Clinical and translational medicine, e1706. https://doi.org/10.1002/ctm2.1706 PMID: 38797938",
                    "38797938"
                ],
                [
                    "Vahid Omarmeli, Kai-Uwe Lewandrowski, Marjan Assefi, Hanieh Faizmahdavi, Alireza Sharafshah, Nasrin Mansouri (2024). A Novel Mutation (Lys31Arg) in the DMD Gene Impacts on Neuromuscular Dysfunctions Found by Whole Exome Sequencing and In Silico Analyses in an Iranian Family. Current aging science, 169-174. https://doi.org/10.2174/0118746098280408240112112414 PMID: 38265407",
                    "38265407"
                ],
                [
                    "David M Rind (2024). The FDA and Gene Therapy for Duchenne Muscular Dystrophy. JAMA, 1705-1706. https://doi.org/10.1001/jama.2024.5613 PMID: 38691382",
                    "38691382"
                ],
                [
                    "X Qiu, J J Guo, C C Jin, J He, L Wang, B C Yang, Y H Zhang, B S Zhu, X H Tang (2024). [Efficiency of CNV-seq in detecting fetal DMD gene deletion or duplication in prenatal diagnosis]. Zhonghua fu chan ke za zhi, 279-287. https://doi.org/10.3760/cma.j.cn112141-20230919-00107 PMID: 38644274",
                    "38644274"
                ],
                [
                    "Nalaka Wijekoon, Lakmal Gonawala, Pyara Ratnayake, Pulasthi Dissanayaka, Isuru Gunarathne, Dhammika Amaratunga, Roshan Liyanage, Sunethra Senanayaka, Saraji Wijesekara, Hemal H Gunasekara, Kamala Vanarsa, Jessica Castillo, Yetrib Hathout, Ashwin Dalal, Harry W M Steinbusch, Eric Hoffman, Chandra Mohan, K Ranil D de Silva (2023). Integrated genomic, proteomic and cognitive assessment in Duchenne Muscular Dystrophy suggest astrocyte centric pathology. Heliyon, e18530. https://doi.org/10.1016/j.heliyon.2023.e18530 PMID: 37593636",
                    "37593636"
                ],
                [
                    "Adi Amar-Schwartz, Yuval Cohen, Antony Elhaj, Vered Ben-Hur, Zahava Siegfried, Rotem Karni, Talya Dor (2023). Inhibition of nonsense-mediated mRNA decay may improve stop codon read-through therapy for Duchenne muscular dystrophy. Human molecular genetics, 2455-2463. https://doi.org/10.1093/hmg/ddad072 PMID: 37145099",
                    "37145099"
                ],
                [
                    "Akitoshi Chikamoto, Ryota Tochinai, Shin-Ichi Sekizawa, Masayoshi Kuwahara (2023). Plasticity occurs in a specific phenotype of neurons in the nucleus tractus solitarius of dystrophin gene-mutated rats. The European journal of neuroscience, 4282-4297. https://doi.org/10.1111/ejn.16179 PMID: 37933572",
                    "37933572"
                ],
                [
                    "Laura Pezzoni, Roberta Brusa, Teresa Difonzo, Francesca Magri, Daniele Velardo, Stefania Corti, Giacomo Pietro Comi, Maria Cristina Saetti (2023). Cognitive abnormalities in Becker muscular dystrophy: a mysterious link between dystrophin deficiency and executive functions. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. https://doi.org/10.1007/s10072-023-07169-x PMID: 37968431",
                    "37968431"
                ],
                [
                    "Ha Rim Shin, Eun-Ji Ko, Yun-Jeong Kang, Hak-Sun Yu, Mee Sun Ock, Hee-Jae Cha (2023). Effect of parasitic infection on muscular function of dystrophin gene (Dmd) deficient mouse. Genes & genomics, 183-190. https://doi.org/10.1007/s13258-022-01355-5 PMID: 36571712",
                    "36571712"
                ]
            ]
        ],
        [
            [
                "dystrophin",
                "myostatin"
            ],
            1.0635987,
            [
                [
                    "Nienke M van de Velde, Zaïda Koeks, Mirko Signorelli, Nisha Verwey, Maurice Overzier, Jaap A Bakker, Gautam Sajeev, James Signorovitch, Valeria Ricotti, Jan Verschuuren, Kristy Brown, Pietro Spitali, Erik H Niks (2023). Longitudinal Assessment of Creatine Kinase, Creatine/Creatinineratio, and Myostatin as Monitoring Biomarkers in Becker Muscular Dystrophy. Neurology, e975-e984. https://doi.org/10.1212/WNL.0000000000201609 PMID: 36849458",
                    "36849458"
                ],
                [
                    "Jiexin Deng, Junshi Zhang, Keli Shi, Zhigang Liu (2022). Drug development progress in duchenne muscular dystrophy. Frontiers in pharmacology, 950651. https://doi.org/10.3389/fphar.2022.950651 PMID: 35935842",
                    "35935842"
                ],
                [
                    "Dominique O Riddell, John C W Hildyard, Rachel C M Harron, Dominic J Wells, Richard J Piercy (2021). Longitudinal assessment of blood-borne musculoskeletal disease biomarkers in the DE50-MD dog model of Duchenne muscular dystrophy. Wellcome open research, 354. https://doi.org/10.12688/wellcomeopenres.17398.2 PMID: 35600245",
                    "35600245"
                ],
                [
                    "Theodora Markati, Liesbeth De Waele, Urlike Schara-Schmidt, Laurent Servais (2021). Lessons Learned from Discontinued Clinical Developments in Duchenne Muscular Dystrophy. Frontiers in pharmacology, 735912. https://doi.org/10.3389/fphar.2021.735912 PMID: 34790118",
                    "34790118"
                ],
                [
                    "Roberta Marozzo, Valentina Pegoraro, Corrado Angelini (2020). MiRNAs, Myostatin, and Muscle MRI Imaging as Biomarkers of Clinical Features in Becker Muscular Dystrophy. Diagnostics (Basel, Switzerland). https://doi.org/10.3390/diagnostics10090713 PMID: 32961888",
                    "32961888"
                ],
                [
                    "Danielle Vaughan, Oliver Kretz, Ali Alqallaf, Robert Mitchell, Jennie L von der Heide, Sakthivel Vaiyapuri, Antonios Matsakas, Arja Pasternack, Henry Collins-Hooper, Olli Ritvos, Randy Ballesteros, Tobias B Huber, Helge Amthor, Abir Mukherjee, Ketan Patel (2020). Diminution in sperm quantity and quality in mouse models of Duchenne Muscular Dystrophy induced by a myostatin-based muscle growth-promoting intervention. European journal of translational myology, 8904. https://doi.org/10.4081/ejtm.2019.8904 PMID: 32782759",
                    "32782759"
                ],
                [
                    "Ning Ran, Xianjun Gao, Xue Dong, Junjin Li, Caorui Lin, Mengyuan Geng, HaiFang Yin (2020). Effects of exosome-mediated delivery of myostatin propeptide on functional recovery of mdx mice. Biomaterials, 119826. https://doi.org/10.1016/j.biomaterials.2020.119826 PMID: 32028167",
                    "32028167"
                ],
                [
                    "Ngoc Lu-Nguyen, Arnaud Ferry, Frederick J Schnell, Gunnar J Hanson, Linda Popplewell, George Dickson, Alberto Malerba (2019). Functional muscle recovery following dystrophin and myostatin exon splice modulation in aged mdx mice. Human molecular genetics, 3091-3100. https://doi.org/10.1093/hmg/ddz125 PMID: 31179493",
                    "31179493"
                ],
                [
                    "Saleh Omairi, Kwan-Leong Hau, Henry Collins-Hooper, Charlotte Scott, Sakthivel Vaiyapuri, Silvia Torelli, Federica Montanaro, Antonios Matsakas, Ketan Patel (2019). Regulation of the dystrophin-associated glycoprotein complex composition by the metabolic properties of muscle fibres. Scientific reports, 2770. https://doi.org/10.1038/s41598-019-39532-4 PMID: 30808964",
                    "30808964"
                ],
                [
                    "Dong-Ho Bak, Mi Ji Choi, Esther Lee, Tae-Rin Kwon, Jong Hwan Kim, Sang-Hyun Nam, Kyoung-Yun Kim, Seung Won Ahn, Seog-Kyun Mun, Jungtae Na, Beom Joon Kim (2019). A comparison study of prabotulinumtoxinA vs onabotulinumtoxinA in myostatin-deficient mice with muscle hypertrophy. Basic & clinical pharmacology & toxicology, 491-499. https://doi.org/10.1111/bcpt.13151 PMID: 30326173",
                    "30326173"
                ]
            ]
        ]
    ]
}