{
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                "5DTM Crystal structure of Dot1L in complex with inhibitor CPD1 [4-(2,6-dichlorobenzoyl)-N-methyl-1H-pyrrole-2-carboxamide]",
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                [
                    "Robert J Norgard, Pratha Budhani, Sarah A O'Brien, Youli Xia, Jessica N Egan, Brianna Flynn, Joshua R Tagore, Joseph Seco, Gregory W Peet, Ania Mikucka, Ruby Wasti, Li-Chuan Chan, Melanie Hinkel, Sandra Martinez-Morilla, Jeanine Pignatelli, Francesca Trapani, Emily Corse, Di Feng, Kaja Kostyrko, Marco H Hofmann, Kang Liu, Abhishek S Kashyap (2024). Reshaping the Tumor Microenvironment of KRASG12D Pancreatic Ductal Adenocarcinoma with Combined SOS1 and MEK Inhibition for Improved Immunotherapy Response. Cancer research communications, 1548-1560. https://doi.org/10.1158/2767-9764.CRC-24-0172 PMID: 38727236",
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                ],
                [
                    "Christopher R Smith, Dan Chen, James G Christensen, René Coulombe, James Féthière, Robin J Gunn, Johan Hollander, Benjamin Jones, John M Ketcham, Shilpi Khare, Jon Kuehler, J David Lawson, Matthew A Marx, Peter Olson, Kelly E Pearson, Cynthia Ren, Denise Tsagris, Thirumalaiselvi Ulaganathan, Inge Van't Veer, Xiaolun Wang, Anthony Ivetac (2024). Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography. Journal of medicinal chemistry, 774-781. https://doi.org/10.1021/acs.jmedchem.3c02140 PMID: 38156904",
                    "38156904"
                ],
                [
                    "Gerhard Hamilton, Marie-Therese Eggerstorfer, Sandra Stickler (2024). Development of PROTACS degrading KRAS and SOS1. Oncology research, 1257-1264. https://doi.org/10.32604/or.2024.051653 PMID: 39055890",
                    "39055890"
                ],
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                    "Venu Thatikonda, Hengyu Lyu, Sabine Jurado, Kaja Kostyrko, Christopher A Bristow, Christoph Albrecht, Donat Alpar, Heribert Arnhof, Oliver Bergner, Karin Bosch, Ningping Feng, Sisi Gao, Daniel Gerlach, Michael Gmachl, Melanie Hinkel, Simone Lieb, Astrid Jeschko, Annette A Machado, Thomas Madensky, Ethan D Marszalek, Mikhila Mahendra, Gabriella Melo-Zainzinger, Jessica M Molkentine, Philipp A Jaeger, David H Peng, Robyn L Schenk, Alexey Sorokin, Sandra Strauss, Francesca Trapani, Scott Kopetz, Christopher P Vellano, Mark Petronczki, Norbert Kraut, Timothy P Heffernan, Joseph R Marszalek, Mark Pearson, Irene C Waizenegger, Marco H Hofmann (2024). Co-targeting SOS1 enhances the antitumor effects of KRASG12C inhibitors by addressing intrinsic and acquired resistance. Nature cancer, 1352-1370. https://doi.org/10.1038/s43018-024-00800-6 PMID: 39103541",
                    "39103541"
                ],
                [
                    "Yan Lv, Zixuan Yang, Yiming Chen, Xuepei Ma, Mengqi Guo, Chengwei Zhang, Xiaolin Jiang, Chengli Wang, Zhuoyue Li, Zhengfu Tai, Xiao Wang, Siqi Zhang, Shumin Ma, Chong Qin (2024). A Potent SOS1 PROTAC Degrader with Synergistic Efficacy in Combination with KRASG12C Inhibitor. Journal of medicinal chemistry, 2487-2511. https://doi.org/10.1021/acs.jmedchem.3c01598 PMID: 38316747",
                    "38316747"
                ],
                [
                    "Guizhen Zhou, Chuan Zhou, Xinyi Ma, Jiahang Xu, Zehui Zhou, Tianfeng Xu, Mingyue Zheng, Sulin Zhang (2024). An updated patent review of SOS1 inhibitors (2022-present). Expert opinion on therapeutic patents, 1199-1213. https://doi.org/10.1080/13543776.2024.2419825 PMID: 39435474",
                    "39435474"
                ],
                [
                    "Zheyao Hu, Jordi Martí (2024). Unraveling atomic-scale mechanisms of GDP extraction catalyzed by SOS1 in KRAS-G12 and KRAS-D12 oncogenes. Computers in biology and medicine, 109599. https://doi.org/10.1016/j.compbiomed.2024.109599 PMID: 39731920",
                    "39731920"
                ],
                [
                    "Zhuoyuan Zhang, Dan Liu, Rui Lv, Haoyan Zhao, Tianjing Li, Yutao Huang, Zhicheng Tian, Xiangyu Gao, Peng Luo, Xin Li (2024). FBL Promotes LPS-Induced Neuroinflammation by Activating the NF-κB Signaling Pathway. Journal of inflammation research, 2217-2231. https://doi.org/10.2147/JIR.S451049 PMID: 38623466",
                    "38623466"
                ],
                [
                    "Yi Zeng, Chenyang Huang, Qiangqiang Hou, Wenhua Jiang, Jiaqi Cheng, Xiaoxing Wu (2024). Design, synthesis, and evaluation of dual son of sevenless 1 (SOS1) and epidermal growth factor receptor (EGFR) inhibitors for the treatment of cancers. Bioorganic chemistry, 107833. https://doi.org/10.1016/j.bioorg.2024.107833 PMID: 39357170",
                    "39357170"
                ],
                [
                    "Brianna R Daley, Heidi M Vieira, Chaitra Rao, Jacob M Hughes, Zaria M Beckley, Dianna H Huisman, Deepan Chatterjee, Nancy E Sealover, Katherine Cox, James W Askew, Robert A Svoboda, Kurt W Fisher, Robert E Lewis, Robert L Kortum (2023). SOS1 and KSR1 modulate MEK inhibitor responsiveness to target resistant cell populations based on PI3K and KRAS mutation status. Proceedings of the National Academy of Sciences of the United States of America, e2313137120. https://doi.org/10.1073/pnas.2313137120 PMID: 37972068",
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